help button home button Am J Pathol International Conference on Pathology of Chest Diseases
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miller, J. W.
Right arrow Articles by Berse, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miller, J. W.
Right arrow Articles by Berse, B.

American Journal of Pathology, Vol 145, 574-584, Copyright © 1994 by American Society for Investigative Pathology

REGULAR ARTICLES

Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model

JW Miller, AP Adamis, DT Shima, PA D'Amore, RS Moulton, MS O'Reilly, J Folkman, HF Dvorak, LF Brown and B Berse
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston 02114.

Ischemia often precedes neovascularization. In ocular neovascularization, such as occurs in diabetic retinopathy, a diffusible angiogenic factor has been postulated to be produced by ischemic retina and to lead to neovascularization of the retina, optic nerve, or iris. However, no angiogenic factor has been conclusively identified that satisfies this hypothesis. Vascular endothelial growth factor/vascular permeability factor, hereafter referred to as VEGF, is a likely candidate for an ocular angiogenic factor because it is a secreted mitogen, specific for endothelial cells, and is upregulated by hypoxia. We investigated the association of VEGF with the development of experimental iris neovascularization in the cynomolgus monkey. Following the production of retinal ischemia by laser occlusion of all branch retinal veins, VEGF was increased in the aqueous fluid, and the aqueous VEGF levels changed synchronously and proportionally with the severity of iris neovascularization. Northern analysis and in situ hybridization revealed that VEGF messenger RNA is upregulated in the ischemic retina. These observations support the hypothesis that ocular neovascularization is regulated by a diffusible factor and identify VEGF as a likely candidate for a retina-derived vascular permeability and angiogenesis factor in vivo.


This article has been cited by other articles:


Home page
 Circ. Res.Home page
K. P. Malabanan, P. Kanellakis, A. Bobik, and L. M. Khachigian
Activation Transcription Factor-4 Induced by Fibroblast Growth Factor-2 Regulates Vascular Endothelial Growth Factor-A Transcription in Vascular Smooth Muscle Cells and Mediates Intimal Thickening in Rat Arteries Following Balloon Injury
Circ. Res., August 15, 2008; 103(4): 378 - 387.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. Hollborn, C. Stathopoulos, A. Steffen, P. Wiedemann, L. Kohen, and A. Bringmann
Positive Feedback Regulation between MMP-9 and VEGF in Human RPE Cells
Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 4360 - 4367.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Nishijima, Y.-S. Ng, L. Zhong, J. Bradley, W. Schubert, N. Jo, J. Akita, S. J. Samuelsson, G. S. Robinson, A. P. Adamis, et al.
Vascular Endothelial Growth Factor-A Is a Survival Factor for Retinal Neurons and a Critical Neuroprotectant during the Adaptive Response to Ischemic Injury
Am. J. Pathol., July 1, 2007; 171(1): 53 - 67.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
N. Singh, P. D. Jani, T. Suthar, S. Amin, and B. K. Ambati
Flt-1 Intraceptor Induces the Unfolded Protein Response, Apoptotic Factors, and Regression of Murine Injury-Induced Corneal Neovascularization
Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 4787 - 4793.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. B. Moy, K. Blackwell, M. H. Wu, and H. J. Granger
Growth factor- and heparin-dependent regulation of constitutive and agonist-mediated human endothelial barrier function
Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2126 - H2135.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
G. S. O. Missotten, I. C. Notting, R. O. Schlingemann, H. J. Zijlmans, C. Lau, P. H. C. Eilers, J. E. E. Keunen, and M. J. Jager
Vascular Endothelial Growth Factor A in Eyes With Uveal Melanoma
Arch Ophthalmol, October 1, 2006; 124(10): 1428 - 1434.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
R. L. e Silva, Y. Saishin, Y. Saishin, H. Akiyama, S. Kachi, S. Aslam, B. Rogers, T. Deering, Y. Y. Gong, S. F. Hackett, et al.
Suppression and Regression of Choroidal Neovascularization by Polyamine Analogues
Invest. Ophthalmol. Vis. Sci., September 1, 2005; 46(9): 3323 - 3330.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
N. Singh, S. Amin, E. Richter, S. Rashid, V. Scoglietti, P. D. Jani, J. Wang, R. Kaur, J. Ambati, Z. Dong, et al.
Flt-1 Intraceptors Inhibit Hypoxia-Induced VEGF Expression In Vitro and Corneal Neovascularization In Vivo
Invest. Ophthalmol. Vis. Sci., May 1, 2005; 46(5): 1647 - 1652.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
D. Husain, I. Kim, D. Gauthier, A. M. Lane, M. K. Tsilimbaris, E. Ezra, E. J. Connolly, N. Michaud, E. S. Gragoudas, C. A. O'Neill, et al.
Safety and Efficacy of Intravitreal Injection of Ranibizumab in Combination With Verteporfin PDT on Experimental Choroidal Neovascularization in the Monkey
Arch Ophthalmol, April 1, 2005; 123(4): 509 - 516.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. Lebherz, A. M. Maguire, A. Auricchio, W. Tang, T. S. Aleman, Z. Wei, R. Grant, A. V. Cideciyan, S. G. Jacobson, J. M. Wilson, et al.
Nonhuman Primate Models for Diabetic Ocular Neovascularization Using AAV2-Mediated Overexpression of Vascular Endothelial Growth Factor
Diabetes, April 1, 2005; 54(4): 1141 - 1149.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Akiyama, T. Tanaka, H. Doi, H. Kanai, T. Maeno, H. Itakura, T. Iida, Y. Kimura, S. Kishi, and M. Kurabayashi
Visible light exposure induces VEGF gene expression through activation of retinoic acid receptor-{alpha} in retinoblastoma Y79 cells
Am J Physiol Cell Physiol, April 1, 2005; 288(4): C913 - C920.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
R. B. Bhisitkul, G. S. Robinson, R. S. Moulton, K. P. Claffey, E. S. Gragoudas, and J. W. Miller
An Antisense Oligodeoxynucleotide Against Vascular Endothelial Growth Factor in a Nonhuman Primate Model of Iris Neovascularization
Arch Ophthalmol, February 1, 2005; 123(2): 214 - 219.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. G. Elner, V. M. Elner, A. Yoshida, R. D. Dick, and G. J. Brewer
Effects of Tetrathiomolybdate in a Mouse Model of Retinal Neovascularization
Invest. Ophthalmol. Vis. Sci., January 1, 2005; 46(1): 299 - 303.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
E. Suganami, H. Takagi, H. Ohashi, K. Suzuma, I. Suzuma, H. Oh, D. Watanabe, T. Ojima, T. Suganami, Y. Fujio, et al.
Leptin Stimulates Ischemia-Induced Retinal Neovascularization: Possible Role of Vascular Endothelial Growth Factor Expressed in Retinal Endothelial Cells
Diabetes, September 1, 2004; 53(9): 2443 - 2448.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
N. Ferrara
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
Endocr. Rev., August 1, 2004; 25(4): 581 - 611.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
V. Poulaki, A. M. Joussen, N. Mitsiades, C. S. Mitsiades, E. F. Iliaki, and A. P. Adamis
Insulin-Like Growth Factor-I Plays a Pathogenetic Role in Diabetic Retinopathy
Am. J. Pathol., August 1, 2004; 165(2): 457 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
R. Z. Renno, Y. Terada, M. J. Haddadin, N. A. Michaud, E. S. Gragoudas, and J. W. Miller
Selective Photodynamic Therapy by Targeted Verteporfin Delivery to Experimental Choroidal Neovascularization Mediated by a Homing Peptide to Vascular Endothelial Growth Factor Receptor-2
Arch Ophthalmol, July 1, 2004; 122(7): 1002 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
P. A. Campochiaro
Reduction of Diabetic Macular Edema by Oral Administration of the Kinase Inhibitor PKC412
Invest. Ophthalmol. Vis. Sci., March 1, 2004; 45(3): 922 - 931.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
A. N. Witmer, B. C. van Blijswijk, C. J.F. van Noorden, G. F.J.M. Vrensen, and R. O. Schlingemann
In Vivo Angiogenic Phenotype of Endothelial Cells and Pericytes Induced by Vascular Endothelial Growth Factor-A
J. Histochem. Cytochem., January 1, 2004; 52(1): 39 - 52.
[Abstract] [Full Text] [PDF]

Home page
 NeoReviewsHome page
A. Madan
Angiogenesis and Antiangiogenesis in the Neonate: Relevance to Retinopathy of Prematurity
NeoReviews, December 1, 2003; 4(12): e356 - 363.
[Full Text] [PDF]

Home page
 CirculationHome page
A. I. Nykanen, R. Krebs, A. Saaristo, P. Turunen, K. Alitalo, S. Yla-Herttuala, P. K. Koskinen, and K. B. Lemstrom
Angiopoietin-1 Protects Against the Development of Cardiac Allograft Arteriosclerosis
Circulation, March 11, 2003; 107(9): 1308 - 1314.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. E. Rakoczy, M. Brankov, A. Fonceca, T. Zaknich, B. C. Rae, and C.-M. Lai
Enhanced Recombinant Adeno-Associated Virus-Mediated Vascular Endothelial Growth Factor Expression in the Adult Mouse Retina: A Potential Model for Diabetic Retinopathy
Diabetes, March 1, 2003; 52(3): 857 - 863.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. Takagi, S. Koyama, H. Seike, H. Oh, A. Otani, M. Matsumura, and Y. Honda
Potential Role of the Angiopoietin/Tie2 System in Ischemia-Induced Retinal Neovascularization
Invest. Ophthalmol. Vis. Sci., January 1, 2003; 44(1): 393 - 402.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
S. R. Boyd, I. Zachary, U. Chakravarthy, G. J. Allen, G. B. Wisdom, I. A. Cree, J. F. Martin, and P. G. Hykin
Correlation of Increased Vascular Endothelial Growth Factor With Neovascularization and Permeability in Ischemic Central Vein Occlusion
Arch Ophthalmol, December 1, 2002; 120(12): 1644 - 1650.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
P L Lip, D C Felmeden, A D Blann, N Matheou, S Thakur, I A Cunliffe, and G Y H Lip
Plasma vascular endothelial growth factor, soluble VEGF receptor FLT-1, and von Willebrand factor in glaucoma
Br. J. Ophthalmol., November 1, 2002; 86(11): 1299 - 1302.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. L. Evans, I. D. Goldfine, B. A. Maddux, and G. M. Grodsky
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
Endocr. Rev., October 1, 2002; 23(5): 599 - 622.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
N. Miyamoto, M. Mandai, H. Takagi, I. Suzuma, K. Suzuma, S. Koyama, A. Otani, H. Oh, and Y. Honda
Contrasting Effect of Estrogen on VEGF Induction under Different Oxygen Status and Its Role in Murine ROP
Invest. Ophthalmol. Vis. Sci., June 1, 2002; 43(6): 2007 - 2014.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. Akiyama, T. Tanaka, T. Maeno, H. Kanai, Y. Kimura, S. Kishi, and M. Kurabayashi
Induction of VEGF Gene Expression by Retinoic Acid through Sp1-Binding Sites in Retinoblastoma Y79 Cells
Invest. Ophthalmol. Vis. Sci., May 1, 2002; 43(5): 1367 - 1374.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
N. Ogata, M. Wada, T. Otsuji, N. Jo, J. Tombran-Tink, and M. Matsumura
Expression of Pigment Epithelium-Derived Factor in Normal Adult Rat Eye and Experimental Choroidal Neovascularization
Invest. Ophthalmol. Vis. Sci., April 1, 2002; 43(4): 1168 - 1175.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
A P Adamis
Is diabetic retinopathy an inflammatory disease?
Br. J. Ophthalmol., April 1, 2002; 86(4): 363 - 365.
[Full Text] [PDF]

Home page
 IOVSHome page
E. J. Duh, H. S. Yang, I. Suzuma, M. Miyagi, E. Youngman, K. Mori, M. Katai, L. Yan, K. Suzuma, K. West, et al.
Pigment Epithelium-Derived Factor Suppresses Ischemia-Induced Retinal Neovascularization and VEGF-Induced Migration and Growth
Invest. Ophthalmol. Vis. Sci., March 1, 2002; 43(3): 821 - 829.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. N. Witmer, H. G. Blaauwgeers, H. A. Weich, K. Alitalo, G. F. J. M. Vrensen, and R. O. Schlingemann
Altered Expression Patterns of VEGF Receptors in Human Diabetic Retina and in Experimental VEGF-Induced Retinopathy in Monkey
Invest. Ophthalmol. Vis. Sci., March 1, 2002; 43(3): 849 - 857.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. Griggs, J. N. Skepper, G. A. Smith, K. M. Brindle, J. C. Metcalfe, and R. Hesketh
Inhibition of Proliferative Retinopathy by the Anti-Vascular Agent Combretastatin-A4
Am. J. Pathol., March 1, 2002; 160(3): 1097 - 1103.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Ohno-Matsui, A. Hirose, S. Yamamoto, J. Saikia, N. Okamoto, P. Gehlbach, E. J. Duh, S. Hackett, M. Chang, D. Bok, et al.
Inducible Expression of Vascular Endothelial Growth Factor in Adult Mice Causes Severe Proliferative Retinopathy and Retinal Detachment
Am. J. Pathol., February 1, 2002; 160(2): 711 - 719.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Otani, B. M. Slike, M. I. Dorrell, J. Hood, K. Kinder, K. L. Ewalt, D. Cheresh, P. Schimmel, and M. Friedlander
A fragment of human TrpRS as a potent antagonist of ocular angiogenesis
PNAS, January 1, 2002; (2002) 12601899.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. M. Isner, P. R. Vale, J. F. Symes, and D. W. Losordo
Assessment of Risks Associated With Cardiovascular Gene Therapy in Human Subjects
Circ. Res., August 31, 2001; 89(5): 389 - 400.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. Hangai, T. Murata, N. Miyawaki, C. Spee, J. I. Lim, S. He, D. R. Hinton, and S. J. Ryan
Angiopoietin-1 Upregulation by Vascular Endothelial Growth Factor in Human Retinal Pigment Epithelial Cells
Invest. Ophthalmol. Vis. Sci., June 1, 2001; 42(7): 1617 - 1625.
[Abstract] [Full Text]

Home page
 DiabetesHome page
M. Emoto, T. Anno, Y. Sato, K. Tanabe, S. Okuya, Y. Tanizawa, A. Matsutani, and Y. Oka
Troglitazone Treatment Increases Plasma Vascular Endothelial Growth Factor in Diabetic Patients and Its mRNA in 3T3-L1 Adipocytes
Diabetes, May 1, 2001; 50(5): 1166 - 1170.
[Abstract] [Full Text]

Home page
 IOVSHome page
R. F. Gariano, A. K. Nath, D. J. D’Amico, T. Lee, and M. R. Sierra–Honigmann
Elevation of Vitreous Leptin in Diabetic Retinopathy and Retinal Detachment
Invest. Ophthalmol. Vis. Sci., October 1, 2000; 41(11): 3576 - 3581.
[Abstract] [Full Text]

Home page
 IOVSHome page
J. Baffi, G. Byrnes, C.-C. Chan, and K. G. Csaky
Choroidal Neovascularization in the Rat Induced by Adenovirus Mediated Expression of Vascular Endothelial Growth Factor
Invest. Ophthalmol. Vis. Sci., October 1, 2000; 41(11): 3582 - 3589.
[Abstract] [Full Text]

Home page
 IOVSHome page
N. Kwak, N. Okamoto, J. M. Wood, and P. A. Campochiaro
VEGF Is Major Stimulator in Model of Choroidal Neovascularization
Invest. Ophthalmol. Vis. Sci., September 1, 2000; 41(10): 3158 - 3164.
[Abstract] [Full Text]

Home page
 IOVSHome page
W. Philipp, L. Speicher, and C. Humpel
Expression of Vascular Endothelial Growth Factor and Its Receptors in Inflamed and Vascularized Human Corneas
Invest. Ophthalmol. Vis. Sci., August 1, 2000; 41(9): 2514 - 2522.
[Abstract] [Full Text]

Home page
 IOVSHome page
Y. Hasebe, L. R. Thomson, and C. K. Dorey
Pentoxifylline Inhibition of Vasculogenesis in the Neonatal Rat Retina
Invest. Ophthalmol. Vis. Sci., August 1, 2000; 41(9): 2774 - 2778.
[Abstract] [Full Text]

Home page
 IOVSHome page
S. Hughes, H. Yang, and T. Chan-Ling
Vascularization of the Human Fetal Retina: Roles of Vasculogenesis and Angiogenesis
Invest. Ophthalmol. Vis. Sci., April 1, 2000; 41(5): 1217 - 1228.
[Abstract] [Full Text]

Home page
 IOVSHome page
J. R. Mathura Jr, N. Jafari, J. T. Chang, S. F. Hackett, K. J. Wahlin, N. G. Della, N. Okamoto, D. J. Zack, and P. A. Campochiaro
Bone Morphogenetic Proteins-2 and -4: Negative Growth Regulators in Adult Retinal Pigmented Epithelium
Invest. Ophthalmol. Vis. Sci., February 1, 2000; 41(2): 592 - 600.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
H. Ozaki, M.-S. Seo, K. Ozaki, H. Yamada, E. Yamada, N. Okamoto, F. Hofmann, J. M. Wood, and P. A. Campochiaro
Blockade of Vascular Endothelial Cell Growth Factor Receptor Signaling Is Sufficient to Completely Prevent Retinal Neovascularization
Am. J. Pathol., February 1, 2000; 156(2): 697 - 707.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
M. J. Tolentino, D. Husain, P. Theodosiadis, E. S. Gragoudas, E. Connolly, J. Kahn, J. Cleland, A. P. Adamis, A. Cuthbertson, and J. W Miller
Angiography of Fluoresceinated Anti-Vascular Endothelial Growth Factor Antibody and Dextrans in Experimental Choroidal Neovascularization
Arch Ophthalmol, January 1, 2000; 118(1): 78 - 84.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. E. Hartnett, C. M. Garcia, and P. A. D’Amore
Release of bFGF, an Endothelial Cell Survival Factor, by Osmotic Shock
Invest. Ophthalmol. Vis. Sci., November 1, 1999; 40(12): 2945 - 2951.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. B. Grant, R. W. Tarnuzzer, S. Caballero, M. J. Ozeck, M. I. Davis, P. E. Spoerri, I. Feoktistov, I. Biaggioni, J. C. Shryock, and L. Belardinelli
Adenosine Receptor Activation Induces Vascular Endothelial Growth Factor in Human Retinal Endothelial Cells
Circ. Res., October 15, 1999; 85(8): 699 - 706.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
I. Kim, A. M. Ryan, R. Rohan, S. Amano, S. Agular, J. W. Miller, and A. P. Adamis
Constitutive Expression of VEGF, VEGFR-1, and VEGFR-2 in Normal Eyes
Invest. Ophthalmol. Vis. Sci., August 1, 1999; 40(9): 2115 - 2121.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. Lu, V. L. Perez, N. Ma, K. Miyamoto, H.-B. Peng, J. K. Liao, and A. P. Adamis
VEGF Increases Retinal Vascular ICAM-1 Expression In Vivo
Invest. Ophthalmol. Vis. Sci., July 1, 1999; 40(8): 1808 - 1812.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. S. Seo, N. Kwak, H. Ozaki, H. Yamada, N. Okamoto, E. Yamada, D. Fabbro, F. Hofmann, J. M. Wood, and P. A. Campochiaro
Dramatic Inhibition of Retinal and Choroidal Neovascularization by Oral Administration of a Kinase Inhibitor
Am. J. Pathol., June 1, 1999; 154(6): 1743 - 1753.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Suzuma, H. Takagi, A. Otani, H. Oh, and Y. Honda
Expression of Thrombospondin-1 in Ischemia-Induced Retinal Neovascularization
Am. J. Pathol., February 1, 1999; 154(2): 343 - 354.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
S. G. Elner, R. Strieter, Z. M. Bian, S. Kunkel, L. Mokhtarzaden, M. Johnson, N. Lukacs, and V. M. Elner
Interferon-Induced Protein 10 and Interleukin 8: C-X-C Chemokines Present in Proliferative Diabetic Retinopathy
Arch Ophthalmol, December 1, 1998; 116(12): 1597 - 1601.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. Ozaki, N. Okamoto, S. Ortega, M. Chang, K. Ozaki, S. Sadda, M. A. Vinores, N. Derevjanik, D. J. Zack, C. Basilico, et al.
Basic Fibroblast Growth Factor Is Neither Necessary nor Sufficient for the Development of Retinal Neovascularization
Am. J. Pathol., September 1, 1998; 153(3): 757 - 765.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Hata, E. Duh, K. Zhang, G. S. Robinson, and L. P. Aiello
Transcription Factors Sp1 and Sp3 Alter Vascular Endothelial Growth Factor Receptor Expression through a Novel Recognition Sequence
J. Biol. Chem., July 24, 1998; 273(30): 19294 - 19303.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
A. Iannaccone, C. Letizia, S. Pazzaglia, E. M Vingolo, G. Clemente, and M. R Pannarale
Plasma endothelin-1 concentrations in patients with retinal vein occlusions
Br. J. Ophthalmol., May 1, 1998; 82(5): 498 - 503.
[Abstract] [Full Text]

Home page
 Br. J. Ophthalmol.Home page
M. Boulton, D. Foreman, G. Williams, and D. McLeod
VEGF localisation in diabetic retinopathy
Br. J. Ophthalmol., May 1, 1998; 82(5): 561 - 568.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
Y. Wen, J. L. Edelman, T. Kang, N. Zeng, and G. Sachs
Two Functional Forms of Vascular Endothelial Growth Factor Receptor-2/Flk-1 mRNA Are Expressed in Normal Rat Retina
J. Biol. Chem., January 23, 1998; 273(4): 2090 - 2097.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
Y.-S. Chen, S. F Hackett, C.-L. Schoenfeld, M. A Vinores, S. A Vinores, and P. A Campochiaro
Localisation of vascular endothelial growth factor and its receptors to cells of vascular and avascular epiretinal membranes
Br. J. Ophthalmol., October 1, 1997; 81(10): 919 - 926.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
R. O SCHLINGEMANN and V. W M VAN HINSBERGH
Role of vascular permeability factor/vascular endothelial growth factor in eye disease
Br. J. Ophthalmol., June 1, 1997; 81(6): 501 - 512.
[Full Text] [PDF]

Home page
 Endocr. Rev.Home page
N. Ferrara and T. Davis-Smyth
The Biology of Vascular Endothelial Growth Factor
Endocr. Rev., February 1, 1997; 18(1): 4 - 25.
[Abstract] [Full Text]

Home page
 Br. J. Ophthalmol.Home page
M. Kliffen, H. S Sharma, C. M Mooy, S. Kerkvliet, and P. T V M de Jong
Increased expression of angiogenic growth factors in age-related maculopathy
Br. J. Ophthalmol., February 1, 1997; 81(2): 154 - 162.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. T. Shima, M. Kuroki, U. Deutsch, Y.-S. Ng, A. P. Adamis, and P. A. D'Amore
The Mouse Gene for Vascular Endothelial Growth Factor
J. Biol. C