| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 145, 818-826, Copyright © 1994 by American Society for Investigative Pathology
REGULAR ARTICLES |
NP Sunil-Chandra, J Arno, J Fazakerley and AA Nash
Department of Pathology, University of Cambridge, United Kingdom.
Murine gammaherpesvirus is a natural pathogen of wild rodents. In the laboratory it establishes an infection of epithelial cells and persists in B lymphocytes in a latent form. Inbred mice chronically infected with the virus develop a lymphoproliferative disease (LPD) similar to that seen in patients infected with Epstein-Barr virus. The frequency of LPD over a period of 3 years was 9% of all infected animals, with 50% of these displaying high grade lymphomas. The incidence of LPD was greatly increased when infected mice were treated with cyclosporin A. The majority of mice used in the experiments were BALB/c, although lymphomas were detected in mice on other genetic backgrounds, ie, CBA and B10Br. Lymphomas were associated with both lymphoid and nonlymphoid tissues (liver, lung, and kidney). In all cases of lymphomas studied thus far, there was a mixed B cell (B220+ve) and T cell (CD3+ve) phenotype. The B cells were light chain restricted, indicative of a clonal origin. Variable numbers of virus genome-positive cells were detected by in situ hybridization in and around the lymphomas. In contrast, no lytic antigen-positive cells were detected, indicating that genome-positive cells were either latently infected or undergoing an abortive infection. These observations suggest that murine gammaherpesvirus-infected mice may be an important model to study the pathogenesis of LPD associated with other gammaherpesviruses, such as Epstein-Barr virus.
This article has been cited by other articles:
 |
|
 |
|
  L. M. Gargano, J. M. Moser, and S. H. Speck Role for MyD88 Signaling in Murine Gammaherpesvirus 68 Latency J. Virol., April 15, 2008; 82(8): 3853 - 3863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hausler, B. Sellhaus, S. Scheithauer, B. Gaida, S. Kuropka, K. Siepmann, A. Panek, W. Berg, A. Teubner, K. Ritter, et al. Myocarditis in newborn wild-type BALB/c mice infected with the murine gamma herpesvirus MHV-68 Cardiovasc Res, November 1, 2007; 76(2): 323 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Steed, T. Buch, A. Waisman, and H. W. Virgin IV Gamma Interferon Blocks Gammaherpesvirus Reactivation from Latency in a Cell Type-Specific Manner J. Virol., June 1, 2007; 81(11): 6134 - 6140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Gasper-Smith, I. Marriott, and K. L. Bost Murine {gamma}-Herpesvirus 68 Limits Naturally Occurring CD4+CD25+ T Regulatory Cell Activity following Infection J. Immunol., October 1, 2006; 177(7): 4670 - 4678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Liang, M. T. Pickering, N.-H. Cho, H. Chang, M. R. Volkert, T. F. Kowalik, and J. U. Jung Deregulation of DNA Damage Signal Transduction by Herpesvirus Latency-Associated M2. J. Virol., June 1, 2006; 80(12): 5862 - 5874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Bilello, S. M. Lang, F. Wang, J. C. Aster, and R. C. Desrosiers Infection and persistence of rhesus monkey rhadinovirus in immortalized B-cell lines. J. Virol., April 1, 2006; 80(7): 3644 - 3649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Steed, E. S. Barton, S. A. Tibbetts, D. L. Popkin, M. L. Lutzke, R. Rochford, and H. W. Virgin IV Gamma Interferon Blocks Gammaherpesvirus Reactivation from Latency J. Virol., January 1, 2006; 80(1): 192 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Tarakanova, F. Suarez, S. A. Tibbetts, M. A. Jacoby, K. E. Weck, J. L. Hess, S. H. Speck, and H. W. Virgin IV Murine Gammaherpesvirus 68 Infection Is Associated with Lymphoproliferative Disease and Lymphoma in BALB {beta}2 Microglobulin-Deficient Mice J. Virol., December 1, 2005; 79(23): 14668 - 14679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. O. Willer and S. H. Speck Establishment and Maintenance of Long-Term Murine Gammaherpesvirus 68 Latency in B Cells in the Absence of CD40 J. Virol., March 1, 2005; 79(5): 2891 - 2899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Rickabaugh, H. J. Brown, T.-T. Wu, M. J. Song, S. Hwang, H. Deng, K. Mitsouras, and R. Sun Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 RTA Reactivates Murine Gammaherpesvirus 68 from Latency J. Virol., March 1, 2005; 79(5): 3217 - 3222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Islas-Ohlmayer, A. Padgett-Thomas, R. Domiati-Saad, M. W. Melkus, P. D. Cravens, M. d. P. Martin, G. Netto, and J. V. Garcia Experimental Infection of NOD/SCID Mice Reconstituted with Human CD34+ Cells with Epstein-Barr Virus J. Virol., December 15, 2004; 78(24): 13891 - 13900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Yarilin, J. Valiando, and D. N. Posnett A Mouse Herpesvirus Induces Relapse of Experimental Autoimmune Arthritis by Infection of the Inflammatory Target Tissue J. Immunol., October 15, 2004; 173(8): 5238 - 5246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Rickabaugh, H. J. Brown, D. Martinez-Guzman, T.-T. Wu, L. Tong, F. Yu, S. Cole, and R. Sun Generation of a Latency-Deficient Gammaherpesvirus That Is Protective against Secondary Infection J. Virol., September 1, 2004; 78(17): 9215 - 9223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Douglas, B. Dutia, S. Rhind, J. P. Stewart, and S. J. Talbot Expression in a Recombinant Murid Herpesvirus 4 Reveals the In Vivo Transforming Potential of the K1 Open Reading Frame of Kaposi's Sarcoma-Associated Herpesvirus J. Virol., August 15, 2004; 78(16): 8878 - 8884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Sparks-Thissen, D. C. Braaten, S. Kreher, S. H. Speck, and H. W. Virgin IV An Optimized CD4 T-Cell Response Can Control Productive and Latent Gammaherpesvirus Infection J. Virol., July 1, 2004; 78(13): 6827 - 6835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. McClellan, S. A. Tibbetts, S. Gangappa, K. A. Brett, and H. W. Virgin IV Critical Role of CD4 T Cells in an Antibody-Independent Mechanism of Vaccination against Gammaherpesvirus Latency J. Virol., July 1, 2004; 78(13): 6836 - 6845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Townsley, B. M. Dutia, and A. A. Nash The M4 Gene of Murine Gammaherpesvirus Modulates Productive and Latent Infection In Vivo J. Virol., January 15, 2004; 78(2): 758 - 767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Boname, H. M. Coleman, J. S. May, and P. G. Stevenson Protection against wild-type murine gammaherpesvirus-68 latency by a latency-deficient mutant J. Gen. Virol., January 1, 2004; 85(1): 131 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Elsawa and K. L. Bost Murine {gamma}-Herpesvirus-68-Induced IL-12 Contributes to the Control of Latent Viral Burden, but Also Contributes to Viral-Mediated Leukocytosis J. Immunol., January 1, 2004; 172(1): 516 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Symensma, D. Martinez-Guzman, Q. Jia, E. Bortz, T.-T. Wu, N. Rudra-Ganguly, S. Cole, H. Herschman, and R. Sun COX-2 Induction during Murine Gammaherpesvirus 68 Infection Leads to Enhancement of Viral Gene Expression J. Virol., December 1, 2003; 77(23): 12753 - 12763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gangappa, S. B. Kapadia, S. H. Speck, and H. W. Virgin IV Antibody to a Lytic Cycle Viral Protein Decreases Gammaherpesvirus Latency in B-Cell-Deficient Mice J. Virol., October 17, 2002; 76(22): 11460 - 11468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. P. L. Chiu, E. Ivakine, S. Mortin-Toth, and J. S. Danska Susceptibility to Lymphoid Neoplasia in Immunodeficient Strains of Nonobese Diabetic Mice Cancer Res., October 15, 2002; 62(20): 5828 - 5834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Ahn, K. L. Powell, P. Kellam, and D. G. Alber Gammaherpesvirus Lytic Gene Expression as Characterized by DNA Array J. Virol., May 13, 2002; 76(12): 6244 - 6256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Wakeling, D. J. Roy, A. A. Nash, and J. P. Stewart Characterization of the murine gammaherpesvirus 68 ORF74 product: a novel oncogenic G protein-coupled receptor J. Gen. Virol., May 1, 2001; 82(5): 1187 - 1197. [Abstract] [Full Text]
|
|
|
|
|
|
K. A. Robertson, E. J. Usherwood, and A. A. Nash Regression of a Murine Gammaherpesvirus 68-Positive B-Cell Lymphoma Mediated by CD4 T Lymphocytes J. Virol., April 1, 2001; 75(7): 3480 - 3482. [Abstract] [Full Text]
|
|
|
|
|
|
K. M. Haan, A. Aiyar, and R. Longnecker Establishment of Latent Epstein-Barr Virus Infection and Stable Episomal Maintenance in Murine B-Cell Lines J. Virol., March 15, 2001; 75(6): 3016 - 3020. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Ensser, D. Glykofrydes, H. Niphuis, E. M. Kuhn, B. Rosenwirth, J. L. Heeney, G. Niedobitek, I. Muller-Fleckenstein, and B. Fleckenstein Independence of Herpesvirus-induced T Cell Lymphoma from Viral Cyclin D Homologue J. Exp. Med., March 5, 2001; 193(5): 637 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Grayson, K. Murali-Krishna, J. D. Altman, and R. Ahmed Gene Expression in Antigen-Specific CD8+ T Cells During Viral Infection J. Immunol., January 15, 2001; 166(2): 795 - 799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Terry, J. P. Stewart, A. A. Nash, and J. K. Fazakerley Murine gammaherpesvirus-68 infection of and persistence in the central nervous system J. Gen. Virol., November 1, 2000; 81(11): 2635 - 2643. [Abstract] [Full Text]
|
|
|
|
|
|
A. T. Hoge, S. B. Hendrickson, and W. H. Burns Murine Gammaherpesvirus 68 Cyclin D Homologue Is Required for Efficient Reactivation from Latency J. Virol., August 1, 2000; 74(15): 7016 - 7023. [Abstract] [Full Text]
|
|
|
|
|
|
E. T. Clambey, H. W. Virgin IV, and S. H. Speck Disruption of the Murine Gammaherpesvirus 68 M1 Open Reading Frame Leads to Enhanced Reactivation from Latency J. Virol., February 15, 2000; 74(4): 1973 - 1984. [Abstract] [Full Text]
|
|
|
|
|
|
S. Liu, I. V. Pavlova, H. W. Virgin IV, and S. H. Speck Characterization of Gammaherpesvirus 68 Gene 50 Transcription J. Virol., February 15, 2000; 74(4): 2029 - 2037. [Abstract] [Full Text]
|
|
|
|
|
|
J. W. Peacock and K. L. Bost Infection of intestinal epithelial cells and development of systemic disease following gastric instillation of murine gammaherpesvirus-68 J. Gen. Virol., February 1, 2000; 81(2): 421 - 429. [Abstract] [Full Text]
|
|
|
|
|
|
L. Liu, E. J. Usherwood, M. A. Blackman, and D. L. Woodland T-Cell Vaccination Alters the Course of Murine Herpesvirus 68 Infection and the Establishment of Viral Latency in Mice J. Virol., December 1, 1999; 73(12): 9849 - 9857. [Abstract] [Full Text]
|
|
|
|
|
|
B. M. Dutia, J. P. Stewart, R. A. E. Clayton, H. Dyson, and A. A. Nash Kinetic and phenotypic changes in murine lymphocytes infected with murine gammaherpesvirus-68 in vitro J. Gen. Virol., October 1, 1999; 80(10): 2729 - 2736. [Abstract] [Full Text]
|
|
|
|
|
|
G.-H. Wang, T. L. Garvey, and J. I. Cohen The murine gammaherpesvirus-68 M11 protein inhibits Fas- and TNF- induced apoptosis J. Gen. Virol., October 1, 1999; 80(10): 2737 - 2740. [Abstract] [Full Text]
|
|
|
|
|
|
J. K. Whitmire, R. A. Flavell, I. S. Grewal, C. P. Larsen, T. C. Pearson, and R. Ahmed CD40-CD40 Ligand Costimulation Is Required for Generating Antiviral CD4 T Cell Responses But Is Dispensable for CD8 T Cell Responses J. Immunol., September 15, 1999; 163(6): 3194 - 3201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Liu, E. Flano, E. J. Usherwood, S. Surman, M. A. Blackman, and D. L. Woodland Lytic Cycle T Cell Epitopes Are Expressed in Two Distinct Phases During MHV-68 Infection J. Immunol., July 15, 1999; 163(2): 868 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Weck, S. S. Kim, H. W. Virgin IV, and S. H. Speck B Cells Regulate Murine Gammaherpesvirus 68 Latency J. Virol., June 1, 1999; 73(6): 4651 - 4661. [Abstract] [Full Text]
|
|
|
|
|
|
C. Zimmermann and H. Pircher A Novel Approach to Visualize Polyclonal Virus-Specific CD8 T Cells In Vivo J. Immunol., May 1, 1999; 162(9): 5178 - 5182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Weck, S. S. Kim, H. W. Virgin IV, and S. H. Speck Macrophages Are the Major Reservoir of Latent Murine Gammaherpesvirus 68 in Peritoneal Cells J. Virol., April 1, 1999; 73(4): 3273 - 3283. [Abstract] [Full Text]
|
|
|
|
|
|
H. W. Virgin IV, R. M. Presti, X.-Y. Li, C. Liu, and S. H. Speck Three Distinct Regions of the Murine Gammaherpesvirus 68 Genome Are Transcriptionally Active in Latently Infected Mice J. Virol., March 1, 1999; 73(3): 2321 - 2332. [Abstract] [Full Text]
|
|
|
|
|
|
M. A. Blackman and E. Flano Persistent {gamma}-herpesvirus Infections: What Can We Learn from an Experimental Mouse Model? J. Exp. Med., April 1, 2002; 195(7): F29 - F32. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
