| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 145, 868-875, Copyright © 1994 by American Society for Investigative Pathology
REGULAR ARTICLES |
IE Willems, MG Havenith, JG De Mey and MJ Daemen
Department of Pathology, Cardiovascular Research Institute Maastricht, The Netherlands.
Interstitial cells in the scars of human myocardial infarctions of different postinfarction times (6 hours to 17 years old) were characterized by antibodies to alpha-smooth muscle actin (ASMA), vimentin, and desmin. Basal lamina deposition was studied with antibodies to the basal lamina protein type IV collagen. Nonvascular spindle-shaped cells expressing ASMA were present within 4 to 6 days after infarction. These cells co-expressed vimentin but no desmin and showed discontinuous basal lamina deposition. In electron microscopy these cells showed features characteristic of myofibroblasts. The spindle-shaped cells persisted for a long period of time and could even be identified 17 years postinfarction. In transmural infarctions they were orientated parallel to the endocardium and epicardium. In nontransmural patchy infarctions they showed an orientation adjacent to the cardiomyocytes and appeared to be less dense than in the transmural infarctions. In conclusion, myofibroblasts expressing ASMA persist within human myocardial scars and show a preferential alignment that may be the result of the continuous mechanical stress caused by the ongoing contraction and relaxation of the surrounding viable myocardium.
This article has been cited by other articles:
 |
|
 |
|
  S. W.M. van den Borne, V. A.M. van de Schans, A. E. Strzelecka, H. T.M. Vervoort-Peters, P. M. Lijnen, J. P.M. Cleutjens, J. F.M. Smits, M. J.A.P. Daemen, B. J.A. Janssen, and W. M. Blankesteijn Mouse strain determines the outcome of wound healing after myocardial infarction Cardiovasc Res, November 1, 2009; 84(2): 273 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Berni, M. Savi, L. Bocchi, F. Delucchi, E. Musso, C. Chaponnier, G. Gabbiani, S. Clement, and D. Stilli Modulation of actin isoform expression before the transition from experimental compensated pressure-overload cardiac hypertrophy to decompensation Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1625 - H1632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W.M. van den Borne, S. Isobe, J. W. Verjans, A. Petrov, D. Lovhaug, P. Li, H. R. Zandbergen, Y. Ni, P. Frederik, J. Zhou, et al. Molecular Imaging of Interstitial Alterations in Remodeling Myocardium After Myocardial Infarction J. Am. Coll. Cardiol., December 9, 2008; 52(24): 2017 - 2028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. G. Spinale Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function Physiol Rev, October 1, 2007; 87(4): 1285 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mollmann, H. M. Nef, S. Kostin, C. von Kalle, I. Pilz, M. Weber, J. Schaper, C. W. Hamm, and A. Elsasser Bone marrow-derived cells contribute to infarct remodelling Cardiovasc Res, September 1, 2006; 71(4): 661 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Levick, D. Loch, B. Rolfe, R. C. Reid, D. P. Fairlie, S. M. Taylor, and L. Brown Antifibrotic Activity of an Inhibitor of Group IIA Secretory Phospholipase A2 in Young Spontaneously Hypertensive Rats. J. Immunol., June 1, 2006; 176(11): 7000 - 7007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-H. Park, S. F. Nagueh, D. S. Khoury, H. A. Kopelen, S. Akrivakis, K. Nasser, G. Ren, and N. G. Frangogiannis Impact of myocardial structure and function postinfarction on diastolic strain measurements: implications for assessment of myocardial viability Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H724 - H731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bogun, S. Krishnan, M. Siddiqui, E. Good, J. E. Marine, C. Schuger, H. Oral, A. Chugh, F. Pelosi, and F. Morady Electrogram Characteristics in Postinfarction Ventricular Tachycardia: Effect of Infarct Age J. Am. Coll. Cardiol., August 16, 2005; 46(4): 667 - 674. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. G. Frangogiannis, G. Ren, O. Dewald, P. Zymek, S. Haudek, A. Koerting, K. Winkelmann, L. H. Michael, J. Lawler, and M. L. Entman Critical Role of Endogenous Thrombospondin-1 in Preventing Expansion of Healing Myocardial Infarcts Circulation, June 7, 2005; 111(22): 2935 - 2942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ertl and S. Frantz Healing after myocardial infarction Cardiovasc Res, April 1, 2005; 66(1): 22 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Freed, R. H. Cunnington, A. L. Dangerfield, J. S. Sutton, and I. M.C. Dixon Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart Cardiovasc Res, March 1, 2005; 65(4): 782 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dobaczewski, S. Akrivakis, K. Nasser, L. H. Michael, M. L. Entman, and N. G. Frangogiannis Vascular Mural Cells in Healing Canine Myocardial Infarcts J. Histochem. Cytochem., August 1, 2004; 52(8): 1019 - 1029. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Wang, S. Clement, G. Gabbiani, J.-D. Horisberger, M. Burnier, B. C. Rossier, and E. Hummler Chronic hyperaldosteronism in a transgenic mouse model fails to induce cardiac remodeling and fibrosis under a normal-salt diet Am J Physiol Renal Physiol, June 1, 2004; 286(6): F1178 - F1184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Dewald, G. Ren, G. D. Duerr, M. Zoerlein, C. Klemm, C. Gersch, S. Tincey, L. H. Michael, M. L. Entman, and N. G. Frangogiannis Of Mice and Dogs: Species-Specific Differences in the Inflammatory Response Following Myocardial Infarction Am. J. Pathol., February 1, 2004; 164(2): 665 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Virag and C. E. Murry Myofibroblast and Endothelial Cell Proliferation during Murine Myocardial Infarct Repair Am. J. Pathol., December 1, 2003; 163(6): 2433 - 2440. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. Gaudesius, M. Miragoli, S. P. Thomas, and S. Rohr Coupling of Cardiac Electrical Activity Over Extended Distances by Fibroblasts of Cardiac Origin Circ. Res., September 5, 2003; 93(5): 421 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Manabe, T. Shindo, and R. Nagai Gene Expression in Fibroblasts and Fibrosis: Involvement in Cardiac Hypertrophy Circ. Res., December 13, 2002; 91(12): 1103 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. van Gijn, M. J.A.P. Daemen, J. F.M. Smits, and W.M. Blankesteijn The wnt-frizzled cascade in cardiovascular disease Cardiovasc Res, July 1, 2002; 55(1): 16 - 24. [Full Text] [PDF]
|
|
|
|
|
|
C. Basso, G. Thiene, M. Della Barbera, A. Angelini, M. Kirchengast, and S. Iliceto Endothelin A-receptor antagonist administration immediately after experimental myocardial infarction with reperfusion does not affect scar healing in dogs Cardiovasc Res, July 1, 2002; 55(1): 113 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ren, L. H. Michael, M. L. Entman, and N. G. Frangogiannis Morphological Characteristics of the Microvasculature in Healing Myocardial Infarcts J. Histochem. Cytochem., January 1, 2002; 50(1): 71 - 80. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. J. van SUYLEN, W. M. AARTSEN, J. F. M. SMITS, and M. J. A. P. DAEMEN Dissociation of Pulmonary Vascular Remodeling and Right Ventricular Pressure in Tissue Angiotensin-converting Enzyme-deficient Mice Under Conditions of Chronic Alveolar Hypoxia Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1241 - 1245. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Pathak, S. Sarkar, E. Vellaichamy, and S. Sen Role of Myocytes in Myocardial Collagen Production Hypertension, March 1, 2001; 37(3): 833 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. T Weber and Yao Sun Recruitable ACE and tissue repair in the infarcted heart Journal of Renin-Angiotensin-Aldosterone System, December 1, 2000; 1(4): 295 - 303. [PDF]
|
|
|
|
|
|
V. V Petrov, R. H Fagard, and P. J Lijnen Transforming growth factor-{beta}1 induces angiotensin-converting enzyme synthesis in rat cardiac fibroblasts during their differentiation to myofibroblasts Journal of Renin-Angiotensin-Aldosterone System, December 1, 2000; 1(4): 342 - 352. [Abstract] [PDF]
|
|
|
|
|
|
N. G. Frangogiannis, L. H. Michael, and M. L. Entman Myofibroblasts in reperfused myocardial infarcts express the embryonic form of smooth muscle myosin heavy chain (SMemb) Cardiovasc Res, October 1, 2000; 48(1): 89 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-C. Hsu, M. H. Spilker, I. V. Yannas, and P. A. D. Rubin Inhibition of Conjunctival Scarring and Contraction by a Porous Collagen-Glycosaminoglycan Implant Invest. Ophthalmol. Vis. Sci., August 1, 2000; 41(9): 2404 - 2411. [Abstract] [Full Text]
|
|
|
|
|
|
E. Creemers, J. Cleutjens, J. Smits, S. Heymans, L. Moons, D. Collen, M. Daemen, and P. Carmeliet Disruption of the Plasminogen Gene in Mice Abolishes Wound Healing after Myocardial Infarction Am. J. Pathol., June 1, 2000; 156(6): 1865 - 1873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sun and K. T. Weber Infarct scar: a dynamic tissue Cardiovasc Res, May 1, 2000; 46(2): 250 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. H. Schiffers, D. Henrion, C. M. Boulanger, E. Colucci-Guyon, F. Langa-Vuves, H. van Essen, G. E. Fazzi, B. I. Levy, and J. G. R. De Mey Altered Flow-Induced Arterial Remodeling in Vimentin-Deficient Mice Arterioscler Thromb Vasc Biol, March 1, 2000; 20(3): 611 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Oparil, S.-J. Chen, Y.-F. Chen, J. N Durand, L. Allen, and J. A Thompson Estrogen attenuates the adventitial contribution to neointima formation in injured rat carotid arteries Cardiovasc Res, December 1, 1999; 44(3): 608 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Clement, C. Chaponnier, and G. Gabbiani A Subpopulation of Cardiomyocytes Expressing {alpha}-Skeletal Actin Is Identified by a Specific Polyclonal Antibody Circ. Res., November 12, 1999; 85 (10): e51 - e58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P.M Cleutjens, W.M. Blankesteijn, M. J.A.P Daemen, and J. F.M Smits The infarcted myocardium: Simply dead tissue, or a lively target for therapeutic interventions Cardiovasc Res, November 1, 1999; 44(2): 232 - 241. [Full Text] [PDF]
|
|
|
|
|
|
G. Li, Y.-F. Chen, G. L. Greene, S. Oparil, and J. A. Thompson Estrogen Inhibits Vascular Smooth Muscle Cell-Dependent Adventitial Fibroblast Migration In Vitro Circulation, October 12, 1999; 100(15): 1639 - 1645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ono, H. Ono, H. Matsuoka, T. Fujimori, and E. D. Frohlich Apoptosis, Coronary Arterial Remodeling, and Myocardial Infarction After Nitric Oxide Inhibition in SHR Hypertension, October 1, 1999; 34(4): 609 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Li, M. Setoguchi, X. Wang, A. M. Andreoli, A. Leri, A. Malhotra, J. Kajstura, and P. Anversa Insulin-Like Growth Factor-1 Attenuates the Detrimental Impact of Nonocclusive Coronary Artery Constriction on the Heart Circ. Res., May 14, 1999; 84(9): 1007 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Peterson, H. Ju, J. Hao, M. Panagia, D. C. Chapman, and I. M.C. Dixon Expression of Gi-2{alpha} and Gs{alpha} in myofibroblasts localized to the infarct scar in heart failure due to myocardial infarction Cardiovasc Res, March 1, 1999; 41(3): 575 - 585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Kelley, R. Malekan, J. H. Gorman III, B. M. Jackson, R. C. Gorman, Y. Suzuki, T. Plappert, D. K. Bogen, M. G. St. J. Sutton, and L. H. Edmunds Jr Restraining Infarct Expansion Preserves Left Ventricular Geometry and Function After Acute Anteroapical Infarction Circulation, January 12, 1999; 99(1): 135 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yamate, A. Okado, M. Kuwamura, Y. Tsukamoto, F. Ohashi, Y. Kiso, S. Nakatsuji, T. Kotani, S. Sakuma, and J. Lamarre Immunohistochemical Analysis of Macrophages, Myofibroblasts, and Transforming Growth Factor-{beta} Localization during Rat Renal Interstitial Fibrosis Following Long-Term Unilateral Ureteral Obstruction Toxicol Pathol, November 1, 1998; 26(6): 793 - 801. [Abstract] [PDF]
|
|
|
|
|
|
N. G. Frangogiannis, J. L. Perrard, L. H. Mendoza, A. R. Burns, M. L. Lindsey, C. M. Ballantyne, L. H. Michael, C. W. Smith, and M. L. Entman Stem Cell Factor Induction Is Associated With Mast Cell Accumulation After Canine Myocardial Ischemia and Reperfusion Circulation, August 18, 1998; 98(7): 687 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Takemura, M. Ohno, Y. Hayakawa, J. Misao, M. Kanoh, A. Ohno, Y. Uno, S. Minatoguchi, T. Fujiwara, and H. Fujiwara Role of Apoptosis in the Disappearance of Infiltrated and Proliferated Interstitial Cells After Myocardial Infarction Circ. Res., June 15, 1998; 82(11): 1130 - 1138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Anversa and J. Kajstura Myocyte Cell Death in the Diseased Heart Circ. Res., June 15, 1998; 82(11): 1231 - 1233. [Full Text] [PDF]
|
|
|
|
|
|
H. Ju, S. Zhao, P. S. Tappia, V. Panagia, and I. M. C. Dixon Expression of Gq{alpha} and PLC-ß in Scar and Border Tissue in Heart Failure Due to Myocardial Infarction Circulation, March 10, 1998; 97(9): 892 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T. Weber Extracellular Matrix Remodeling in Heart Failure : A Role for De Novo Angiotensin II Generation Circulation, December 2, 1997; 96(11): 4065 - 4082. [Full Text]
|
|
|
|
|
|
P. Uusimaa, J. Risteli, M. Niemela, J. Lumme, M. Ikaheimo, A. Jounela, and K. Peuhkurinen Collagen Scar Formation After Acute Myocardial Infarction : Relationships to Infarct Size, Left Ventricular Function, and Coronary Artery Patency Circulation, October 21, 1997; 96(8): 2565 - 2572. [Abstract] [Full Text]
|
|
|
|
|
|
H. De Leon, N. A. Scott, F. Martin, L. Simonet, K. E. Bernstein, and J. N. Wilcox Expression of Nonmuscle Myosin Heavy Chain-B Isoform in the Vessel Wall of Porcine Coronary Arteries After Balloon Angioplasty Circ. Res., April 19, 1997; 80(4): 514 - 519. [Abstract] [Full Text]
|
|
|
|
|
|
A. Zalewski and Y. Shi Vascular Myofibroblasts : Lessons From Coronary Repair and Remodeling Arterioscler Thromb Vasc Biol, March 1, 1997; 17(3): 417 - 422. [Full Text]
|
|
|
|
|
|
B. I. Jugdutt, M. J. Joljart, and M. I. Khan Rate of Collagen Deposition During Healing and Ventricular Remodeling After Myocardial Infarction in Rat and Dog Models Circulation, July 1, 1996; 94(1): 94 - 101. [Abstract] [Full Text]
|
|
|
|
|
|
N. A. Scott, G. D. Cipolla, C. E. Ross, B. Dunn, F. H. Martin, L. Simonet, and J. N. Wilcox Identification of a Potential Role for the Adventitia in Vascular Lesion Formation After Balloon Overstretch Injury of Porcine Coronary Arteries Circulation, June 15, 1996; 93(12): 2178 - 2187. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
