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American Journal of Pathology, Vol 147, 1186-1192, Copyright © 1995 by American Society for Investigative Pathology

REGULAR ARTICLES

Apolipoprotein A1-derived amyloid in human aortic atherosclerotic plaques

P Westermark, G Mucchiano, T Marthin, KH Johnson and K Sletten
Department of Pathology I, Linkoping University, Sweden.

Amyloid deposits in the aortic intima are very common in association with atherosclerosis and aging. In the present study, a major fibril protein purified from amyloid present in human atherosclerotic plaques was shown to be a 69-amino acid N-terminal fragment of apolipoprotein AI. Although senile form of localized apolipoprotein AI-derived amyloidosis has recently been documented in pulmonary vessels of dogs, this is the first example of a localized human amyloid derived from this apolipoprotein.

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