help button home button Am J Pathol Epitomics Buy 2 Antibodies Get 1 Free Special Offer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roertgen, K. E.
Right arrow Articles by Johnson, K. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roertgen, K. E.
Right arrow Articles by Johnson, K. H.

American Journal of Pathology, Vol 147, 1311-1317, Copyright © 1995 by American Society for Investigative Pathology

REGULAR ARTICLES

Apolipoprotein AI-derived pulmonary vascular amyloid in aged dogs

KE Roertgen, EM Lund, TD O'Brien, P Westermark, DW Hayden and KH Johnson
Department of Veterinary PathoBiology, University of Minnesota, St. Paul 55108, USA.

Our studies confirm the common occurrence of a unique form of apolipoprotein AI (apoAI)-derived vascular amyloidosis in dogs that appears to be unrelated to other disease conditions, but is associated with aging. Vascular amyloid deposits were most frequently located within the intima and media of medium-sized pulmonary arteries, and were not confirmed in any other tissues. Pulmonary vascular amyloid immunoreactive with antiserum to purified N-terminal (1-71) canine apoAI amyloid protein was demonstrated retrospectively in 12.8% of necropsied dogs (N = 243) 10 years of age or older. In a subsequent expanded 1-year prospective study of necropsied dogs (N = 231) of all ages, apoAI-derived pulmonary vascular amyloid deposits were demonstrated in 0.7% of dogs < 10 years of age and in 22% of dogs 10 years of age or older. The incidence of this form of amyloid in dogs 10 years of age or older was significantly associated with advancing age (P < 0.00001). However, significant differences regarding gender, breed, or the frequency of selected common disease conditions were not observed when the dogs with apoAI-derived amyloid were compared with control dogs. The possibility that this new form of senile apoAI- derived amyloidosis is a manifestation of an age-associated aberration in apoAI metabolism or is related to a mutant form of apoAI is the subject of ongoing investigations.


This article has been cited by other articles:


Home page
 J. Histochem. Cytochem.Home page
N. Sakata, Y. Hoshii, T. Nakamura, M. Kiyama, H. Arai, M. Omoto, M. Morimatsu, and T. Ishihara
Colocalization of Apolipoprotein AI in Various Kinds of Systemic Amyloidosis
J. Histochem. Cytochem., February 1, 2005; 53(2): 237 - 242.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American Society for Investigative Pathology.