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American Journal of Pathology, Vol 147, 1708-1714, Copyright © 1995 by American Society for Investigative Pathology

REGULAR ARTICLES

Peripheral blood leukocyte grafts that induce human to mouse graft-vs.- host disease reject allogeneic human skin grafts

W Huppes and G Hoffmann-Fezer
Division of Health Research, Netherlands Organization for Applied Research (TNO), Rijswijk, The Netherlands.

Allogeneic graft-versus-host disease is characterized by skin, gut, and bile duct destruction by relatively few donor type lymphocytes. In contrast, we can now show that human-to-mouse xenogeneic graft-versus- host disease is characterized by vasculitis and tumor-like infiltrations of the murine lymphohemopoietic organs with many human CD25+, HLA-DR+, CD4+ lymphoblasts. Using the technique of serial transplantation, it appears that at least 90% of the human lymphoblasts were unreactive to murine tissues. It is demonstrated consistently that the donor type lymphoblasts induced typical allogeneic rejection of distantly located full thickness human unmatched fetal skin grafts. The fact that the human grafts show primary immune responses in vivo indicates that the graft-versus-host disease murine model may be suitable for vaccination studies.


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Copyright © 1995 by the American Society for Investigative Pathology.