help button home button Am J Pathol ASIP MEMBERSHIP
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sullivan, K. A.
Right arrow Articles by Feldman, E. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sullivan, K. A.
Right arrow Articles by Feldman, E. L.

American Journal of Pathology, Vol 147, 1790-1798, Copyright © 1995 by American Society for Investigative Pathology

REGULAR ARTICLES

Insulin-like growth factor II in the pathogenesis of human neuroblastoma

KA Sullivan, VP Castle, SM Hanash and EL Feldman
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, USA.

Insulin-like growth factor II (IGF-II) acts as an autocrine growth factor for many in vitro tumor cell lines including neuroblastoma. To examine the role of IGF-II in tumor biology we have analyzed a total of 56 primary neuroblastoma tumor samples for the presence of IGF-II using a combination of mRNA and protein analysis. A group of 21 samples was examined for the presence of IGF-II mRNA by slot blot and a separate group of 37 samples was examined for IGF-II immunoreactivity. IGF-II was detected in 48% of the total tumor specimens analyzed. IGF-II immunoreactivity was observed in cells resembling developing neuroblasts and was confined to the cytoplasm and proximal neurites. The appearance of IGF-II mRNA and protein did not correlate with tumor prognostic features including stage, histology, or N-myc amplification. These data suggest that the expression of IGF-II is not confined to a specific stage of the disease but may have a broader role in the pathogenesis of neuroblastoma.


This article has been cited by other articles:


Home page
 J Mol EndocrinolHome page
C. Fottner, T. Minnemann, S. Kalmbach, and M. M Weber
Overexpression of the insulin-like growth factor I receptor in human pheochromocytomas.
J. Mol. Endocrinol., April 1, 2006; 36(2): 279 - 287.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
V. C. Russo, P. D. Gluckman, E. L. Feldman, and G. A. Werther
The Insulin-Like Growth Factor System and Its Pleiotropic Functions in Brain
Endocr. Rev., December 1, 2005; 26(7): 916 - 943.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Misawa, H. Hosoi, A. Arimoto, T. Shikata, S. Akioka, T. Matsumura, P. J. Houghton, and T. Sawada
N-Myc Induction Stimulated by Insulin-like Growth Factor I through Mitogen-activated Protein Kinase Signaling Pathway in Human Neuroblastoma Cells
Cancer Res., January 1, 2000; 60(1): 64 - 69.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
C. J. Kim, T. Matsuo, K.-H. Lee, and C. J. Thiele
Up-Regulation of Insulin-Like Growth Factor-II Expression Is a Feature of TrkA but Not TrkB Activation in SH-SY5Y Neuroblastoma Cells
Am. J. Pathol., November 1, 1999; 155(5): 1661 - 1670.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American Society for Investigative Pathology.