This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chen, W. G. Articles by Weiss, L. M. Search for Related Content PubMed PubMed Citation Articles by Chen, W. G. Articles by Weiss, L. M.

American Journal of Pathology, Vol 148, 17-23, Copyright © 1996 by American Society for Investigative Pathology

REGULAR ARTICLES

Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue. Type A with a high prevalence of deletions within the latent membrane protein gene

WG Chen, YY Chen, MM Bacchi, CE Bacchi, M Alvarenga and LM Weiss
Department of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA.

Both Epstein-Barr virus (EBV) types A and B are found in endemic Burkitt's lymphoma (BL) occurring in equatorial Africa. We studied 17 cases of Brazilian BL previously demonstrated to be EBV-positive to determine the EBV type as well as the presence of a characteristic 30 bp deletion within the 3' end of the latent membrane protein-1 (LMP-1) gene that may be important to the pathogenesis of several EBV- associated neoplasms. All cases in which the age was known were children. We found type A EBV in 13 of 14 (93%) evaluable cases, and type B in one case. The LMP-1 deletion was found in 12 of 15 (80%) evaluable cases, including the one case of type B EBV, and a similar high prevalence (59%) of the deletion was detected in EBV-positive normal and reactive lymphoid tissues from individuals from the same geographic region. The high proportion of cases associated with type A EBV suggests that immunodeficiency is not an important factor in the pathogenesis of Brazilian BL, in contrast to endemic African BL. The presence of the LMP-1 deletion in a high prevalence in the normal population in this region is unexplained.

This article has been cited by other articles:

				R. Hassan, C. E. Klumb, F. E. Felisbino, D. M. Guiretti, L. R. White, C. G. Stefanoff, M. H. M. Barros, H. N. Seuanez, and I. R. Zalcberg Clinical and demographic characteristics of Epstein-Barr virus-associated childhood Burkitt's lymphoma in Southeastern Brazil: epidemiological insights from an intermediate risk region Haematologica, May 1, 2008; 93(5): 780 - 783. [Abstract] [Full Text] [PDF]

				H. S. Lee, M. S. Chang, H.-K. Yang, B. L. Lee, and W. H. Kim Epstein-Barr Virus-Positive Gastric Carcinoma Has a Distinct Protein Expression Profile in Comparison with Epstein-Barr Virus-Negative Carcinoma Clin. Cancer Res., March 1, 2004; 10(5): 1698 - 1705. [Abstract] [Full Text] [PDF]

				H. Knecht and B. F. Odermatt Rearranged Epstein-Barr Virus Genome in Hodgkin's Disease and Angioimmunoblastic Lymphadenopathy: Swiss Results Am. J. Pathol., July 1, 2003; 163(1): 369 - 370. [Full Text] [PDF]

				X.-G. Zhou, K. Sandvej, P.-J. Li, X.-L. Ji, Q.-H. Yan, X.-P. Zhang, J.-P. Da, and S. J. Hamilton-Dutoit Epstein-Barr virus gene polymorphisms in Chinese Hodgkin's disease cases and healthy donors: identification of three distinct virus variants J. Gen. Virol., May 1, 2001; 82(5): 1157 - 1167. [Abstract] [Full Text]

				K. M. Izumi, E. C. McFarland, E. A. Riley, D. Rizzo, Y. Chen, and E. Kieff The Residues between the Two Transformation Effector Sites of Epstein-Barr Virus Latent Membrane Protein 1 Are Not Critical for B-Lymphocyte Growth Transformation J. Virol., December 1, 1999; 73(12): 9908 - 9916. [Abstract] [Full Text]

				R. J. Johnson, M. Stack, S. A. Hazlewood, M. Jones, C. G. Blackmore, L.-F. Hu, and M. Rowe The 30-Base-Pair Deletion in Chinese Variants of the Epstein-Barr Virus LMP1 Gene Is Not the Major Effector of Functional Differences between Variant LMP1 Genes in Human Lymphocytes J. Virol., May 1, 1998; 72(5): 4038 - 4048. [Abstract] [Full Text] [PDF]

				R. Dolcetti, P. Zancai, V. De Re, A. Gloghini, B. Bigoni, B. Pivetta, S. De Vita, A. Carbone, and M. Boiocchi Epstein-Barr Virus Strains With Latent Membrane Protein-1 Deletions: Prevalence in the Italian Population and High Association With Human Immunodeficiency Virus-Related Hodgkin's Disease Blood, March 1, 1997; 89(5): 1723 - 1731. [Abstract] [Full Text] [PDF]

				L. Quintanilla-Martinez, C. Lome-Maldonado, G. Ott, A. Gschwendtner, E. Gredler, E. Reyes, A. Angeles-Angeles, and F. Fend Primary Non-Hodgkin's Lymphoma of the Intestine: High Prevalence of Epstein-Barr Virus in Mexican Lymphomas as Compared With European Cases Blood, January 15, 1997; 89(2): 644 - 651. [Abstract] [Full Text] [PDF]