This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Christie, R. H. Articles by Hyman, B. T. Search for Related Content PubMed PubMed Citation Articles by Christie, R. H. Articles by Hyman, B. T.

American Journal of Pathology, Vol 148, 399-403, Copyright © 1996 by American Society for Investigative Pathology

REGULAR ARTICLES

Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease

RH Christie, M Freeman and BT Hyman
Neurology Service, Massachusetts General Hospital, Boston 02114, USA.

The macrophage scavenger receptor is a multifunctional receptor whose ligands include oxidized low density lipoprotein (LDL), as well as several other polyanionic macromolecules. Although the capacity of the receptor to bind modified LDL has implicated it in the process of atherosclerosis, its physiological role remains uncertain. We have examined human brain for expression of macrophage scavenger receptor as part of ongoing studies of lipoprotein receptors in the central nervous system. The receptor is expressed on microglia, but not on astrocytes, neurons, or vessel-associated structures. In Alzheimer disease, there is strong expression of the scavenger receptor in association with senile plaques.

This article has been cited by other articles:

				M. L. Getchell, H. Li, R. A. Vaishnav, A. S. Borders, J. Witta, N. Subhedar, W. de Villiers, A. J. Stromberg, and T. V. Getchell Temporal gene expression profiles of target-ablated olfactory epithelium in mice with disrupted expression of scavenger receptor A: impact on macrophages Physiol Genomics, November 21, 2006; 27(3): 245 - 263. [Abstract] [Full Text] [PDF]

				R. Alarcon, C. Fuenzalida, M. Santibanez, and R. von Bernhardi Expression of Scavenger Receptors in Glial Cells: COMPARING THE ADHESION OF ASTROCYTES AND MICROGLIA FROM NEONATAL RATS TO SURFACE-BOUND {beta}-AMYLOID J. Biol. Chem., August 26, 2005; 280(34): 30406 - 30415. [Abstract] [Full Text] [PDF]

				J. B. El Khoury, K. J. Moore, T. K. Means, J. Leung, K. Terada, M. Toft, M. W. Freeman, and A. D. Luster CD36 Mediates the Innate Host Response to {beta}-Amyloid J. Exp. Med., June 16, 2003; 197(12): 1657 - 1666. [Abstract] [Full Text] [PDF]

				J. Santiago-Garcia, T. Kodama, and R. E. Pitas The Class A Scavenger Receptor Binds to Proteoglycans and Mediates Adhesion of Macrophages to the Extracellular Matrix J. Biol. Chem., February 21, 2003; 278(9): 6942 - 6946. [Abstract] [Full Text] [PDF]

				I. S. Coraci, J. Husemann, J. W. Berman, C. Hulette, J. H. Dufour, G. K. Campanella, A. D. Luster, S. C. Silverstein, and J. B. El Khoury CD36, a Class B Scavenger Receptor, Is Expressed on Microglia in Alzheimer's Disease Brains and Can Mediate Production of Reactive Oxygen Species in Response to {beta}-Amyloid Fibrils Am. J. Pathol., January 1, 2002; 160(1): 101 - 112. [Abstract] [Full Text] [PDF]

				J. Husemann and S. C. Silverstein Expression of Scavenger Receptor Class B, Type I, by Astrocytes and Vascular Smooth Muscle Cells in Normal Adult Mouse and Human Brain and in Alzheimer's Disease Brain Am. J. Pathol., March 1, 2001; 158(3): 825 - 832. [Abstract] [Full Text] [PDF]

				S. D. Yan, A. Roher, A. M. Schmidt, and D. M. Stern Cellular Cofactors for Amyloid {beta}-Peptide-Induced Cell Stress : Moving from Cell Culture to in Vivo Am. J. Pathol., November 1, 1999; 155(5): 1403 - 1411. [Full Text] [PDF]

				F. Huang, M. Buttini, T. Wyss-Coray, L. McConlogue, T. Kodama, R. E. Pitas, and L. Mucke Elimination of the Class A Scavenger Receptor Does Not Affect Amyloid Plaque Formation or Neurodegeneration in Transgenic Mice Expressing Human Amyloid Protein Precursors Am. J. Pathol., November 1, 1999; 155(5): 1741 - 1747. [Abstract] [Full Text] [PDF]

				R. Yamin, E. G. Malgeri, J. A. Sloane, W. T. McGraw, and C. R. Abraham Metalloendopeptidase EC 3.4.24.15 Is Necessary for Alzheimer's Amyloid-beta Peptide Degradation J. Biol. Chem., June 25, 1999; 274(26): 18777 - 18784. [Abstract] [Full Text] [PDF]

				V. Della Bianca, S. Dusi, E. Bianchini, I. Dal Pra, and F. Rossi beta -Amyloid Activates the Obardot 2 Forming NADPH Oxidase in Microglia, Monocytes, and Neutrophils. A POSSIBLE INFLAMMATORY MECHANISM OF NEURONAL DAMAGE IN ALZHEIMER'S DISEASE J. Biol. Chem., May 28, 1999; 274(22): 15493 - 15499. [Abstract] [Full Text] [PDF]

				L. Andersson and M. W. Freeman Functional Changes in Scavenger Receptor Binding Conformation Are Induced by Charge Mutants Spanning the Entire Collagen Domain J. Biol. Chem., July 31, 1998; 273(31): 19592 - 19601. [Abstract] [Full Text] [PDF]

				J. Jordan, M. F. Galindo, R. J. Miller, C. A. Reardon, G. S. Getz, and M. J. LaDu Isoform-Specific Effect of Apolipoprotein E on Cell Survival and beta -Amyloid-Induced Toxicity in Rat Hippocampal Pyramidal Neuronal Cultures J. Neurosci., January 1, 1998; 18(1): 195 - 204. [Abstract] [Full Text] [PDF]

				D. M. Paresce, H. Chung, and F. R. Maxfield Slow Degradation of Aggregates of the Alzheimer's Disease Amyloid beta -Protein by Microglial Cells J. Biol. Chem., November 14, 1997; 272(46): 29390 - 29397. [Abstract] [Full Text] [PDF]

				M. Tolar, M. A. Marques, J. A. K. Harmony, and K. A. Crutcher Neurotoxicity of the 22 kDa Thrombin-Cleavage Fragment of Apolipoprotein E and Related Synthetic Peptides Is Receptor-Mediated J. Neurosci., August 1, 1997; 17(15): 5678 - 5686. [Abstract] [Full Text] [PDF]

				S. Du Yan, H. Zhu, J. Fu, S. F. Yan, A. Roher, W. W. Tourtellotte, T. Rajavashisth, X. Chen, G. C. Godman, D. Stern, et al. Amyloid-beta peptide-Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease PNAS, May 13, 1997; 94(10): 5296 - 5301. [Abstract] [Full Text] [PDF]

				M. I. Brazil, H. Chung, and F. R. Maxfield Effects of Incorporation of Immunoglobulin G and Complement Component C1q on Uptake and Degradation of Alzheimer's Disease Amyloid Fibrils by Microglia J. Biol. Chem., May 26, 2000; 275(22): 16941 - 16947. [Abstract] [Full Text] [PDF]

				J. Santiago-Garcia, J. Mas-Oliva, T. L. Innerarity, and R. E. Pitas Secreted Forms of the Amyloid-beta Precursor Protein Are Ligands for the Class A Scavenger Receptor J. Biol. Chem., August 10, 2001; 276(33): 30655 - 30661. [Abstract] [Full Text] [PDF]