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American Journal of Pathology, Vol 148, 707-713, Copyright © 1996 by American Society for Investigative Pathology

REGULAR ARTICLES

Expression of immunoreactive activin A protein in remodeling lesions associated with interstitial pulmonary fibrosis

T Matsuse, A Ikegami, E Ohga, T Hosoi, T Oka, K Kida, M Fukayama, S Inoue, T Nagase, Y Ouchi and Y Fukuchi
Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan.

The expression of activin A, one of the transforming growth factor-beta supergene family, was studied in various pulmonary conditions associated with interstitial pulmonary fibrosis (3 cases with diffuse alveolar damage, 6 cases with idiopathic pulmonary fibrosis, and 1 case with pulmonary fibrosis associated with rheumatoid arthritis) using immunohistochemical techniques on paraffin-embedded sections. Controls consisted of 10 cases with normal pulmonary parenchyma, and 2 cases with primary pulmonary hypertension and 1 case with secondary pulmonary hypertension were also studied. The lung specimens from normal parenchyma weakly expressed immunoreactive activin A on the bronchiolar epithelium. In marked contrast, all of the specimens from cases with diffuse alveolar damage and interstitial pulmonary fibrosis demonstrated strong expression of activin A on metaplastic epithelium, hyperplastic smooth muscle cells, desquamated cells, and alveolar macrophages. Pulmonary arteries from patients with primary or secondary pulmonary hypertension showed abundant immunoreactive activin A on smooth muscle cells. These findings suggest a potential role for this growth factor, activin A, in the pathogenesis of pulmonary tissue remodeling associated with interstitial pulmonary fibrosis.

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