This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gijbels, M. J. Articles by Bruijnzeel, P. L. Search for Related Content PubMed PubMed Citation Articles by Gijbels, M. J. Articles by Bruijnzeel, P. L.

American Journal of Pathology, Vol 148, 941-950, Copyright © 1996 by American Society for Investigative Pathology

REGULAR ARTICLES

Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm)

MJ Gijbels, C Zurcher, G Kraal, GR Elliott, H HogenEsch, G Schijff, HF Savelkoul and PL Bruijnzeel
TNO Prins Maurits Laboratory, Rijsuijk, The Netherlands.

Chronic proliferative dermatitis is a spontaneous mutation in C57BL/Ka mice (cpdm/cpdm), showing alopecia, epithelial hyperproliferation, infiltration by eosinophils and macrophages, and vascular dilatation. To further elucidate its pathogenesis, organs of 1-, 2-, 3-, 4-, 5-, and 6-week-old cpdm/cpdm mice were examined. At 4 weeks, the epidermal thickness was increased, whereas already at 3 weeks, the bromodeoxyuridine incorporation was increased in the basal keratinocytes. However, already at the age of 1 week, skin, lungs, and lymph nodes were infiltrated by eosinophils although no macroscopic lesions were present. Compared with control animals, 6-week-old cpdm/cpdm mice had decreased serum IgE levels and increased numbers of mast cells. From the age of 1 week these mast cells became increasingly IgE positive. In contrast, the mast cells of the control animals remained IgE negative. Mast cells of control and cpdm/cpdm mice were interleukin-4 and tumor necrosis factor-alpha positive. A likely explanation for the tissue infiltration of eosinophils could be the release of interleukin-4 and tumor necrosis factor-alpha from activated mast cells. Tumor necrosis factor-alpha may lead to the expression of E- selectin on endothelial cells, facilitating interleukin-4-mediated eosinophil transendothelial migration. Although various pathogenetic aspects of the cpdm/cpdm mouse need further elucidation, this model can be a tool to study eosinophil infiltration, leukocyte-endothelial cell interactions, and mast cell proliferation. Furthermore, the cpdm/cpdm mouse can be used to study chronic inflammatory skin disease because of the severe epidermal proliferation.

This article has been cited by other articles:

				A. Turturro, P. Duffy, B. Hass, R. Kodell, and R. Hart Survival Characteristics and Age-Adjusted Disease Incidences in C57BL/6 Mice Fed a Commonly Used Cereal-Based Diet Modulated by Dietary Restriction J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2002; 57(11): B379 - 389. [Abstract] [Full Text] [PDF]

				H. HogenEsch, S. Janke, D. Boggess, and J. P. Sundberg Absence of Peyer's Patches and Abnormal Lymphoid Architecture in Chronic Proliferative Dermatitis (cpdm/cpdm) Mice J. Immunol., April 1, 1999; 162(7): 3890 - 3896. [Abstract] [Full Text] [PDF]