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American Journal of Pathology, Vol 148, 1359-1365, Copyright © 1996 by American Society for Investigative Pathology

REGULAR ARTICLES

Thymoma-associated myasthenia gravis. Transplantation of thymoma and extrathymomal thymic tissue into SCID mice

S Spuler, A Sarropoulos, A Marx, R Hohlfeld and H Wekerle
Department of Neuroimmunology, Max-Planck-Institute, Martinsried, Germany.

To study the possible role of thymomas and of extrathymomal thymic tissue in the development and maintenance of myasthenia gravis, we transplanted fragments of either tissue into SCID mice and monitored the production of anti-acetylcholine receptor antibodies in the recipients. Furthermore, the transplants were characterized by immunohistochemistry. Unlike after transplantation of thymus with lymphofollicular hyperplasia that induced high titers of anti- acetylcholine receptor antibodies, thymoma transplants never produced autoantibodies. Mice transplanted with extrathymomal thymic tissue also failed to produce anti-acetylcholine receptor antibodies except one group that received transplants containing hyperplastic extrathymomal tissue. These findings may explain the refractoriness of thymomatous myasthenia to thymectomy.


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Copyright © 1996 by the American Society for Investigative Pathology.