| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 149, 177-185, Copyright © 1996 by American Society for Investigative Pathology
REGULAR ARTICLES |
D Schlaifer, S Krajewski, S Galoin, F Rigal-Huguet, G Laurent, P Massip, J Pris, G Delsol, JC Reed and P Brousset
Service d'Hematologie, Centre Hospitalier Universitaire, Hopital de Purpan, Toulouse, France.
The expression of the apoptosis-regulating genes Bcl-2, Bcl-x, Bax, Mcl- 1, and p53 analyzed in 4 cases of human immunodeficiency virus (HIV)- associated Hodgkin's disease, in 36 cases of HIV-related non-Hodgkin's lymphomas (NHLs), and in 109 cases of non-HIV-related NHLs by using immunohistochemistry. HIV-associated Hodgkin's disease samples were positive for all markers. For the HIV-related NHL samples, 36, 66, 88, 100, and 94% of the cases were Bcl-2, Bcl-x, Bax, Mcl-1, and p53 were found to be expressed in 69, 65, 82, 83, and 42%, respectively. No significant differences were observed in Bax and Mcl-1 staining between HIV-unrelated NHLs of B cell and T cell types. In contrast, Bcl-2 was positive in 66/79 (83%) and 10/30 (33%) of B cell and T cell HIV- unrelated NHLs, respectively (P2 < 0.001). Peculiar patterns were observed for hairy cell leukemia (Bax+, Bcl-2+, Mcl-1-) and for anaplastic large cell lymphoma (Bax+, Mcl-1+, Bcl-2-) in HIV-unrelated NHLs. Of interest, all cases with a positive expression of Bax were also found to express either Mcl-1 and/or Bcl-2, suggesting that Mcl-1 and Bcl-2 may counteract the pro-apoptosis function of Bax in vivo by protein-protein interaction within the tumor cell, as demonstrated previously in vitro. These results suggest that apoptosis regulation may have a role in the pathogenesis of some HIV-related and HIV- unrelated NHLs.
This article has been cited by other articles:
 |
|
 |
|
  R. Berro, C. de la Fuente, Z. Klase, K. Kehn, L. Parvin, A. Pumfery, E. Agbottah, A. Vertes, S. Nekhai, and F. Kashanchi Identifying the Membrane Proteome of HIV-1 Latently Infected Cells J. Biol. Chem., March 16, 2007; 282(11): 8207 - 8218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hoffmann, M. Tiemann, C. Schrader, D. Janssen, E. Wolf, M. Vierbuchen, R. Parwaresch, K. Ernestus, A. Plettenberg, A. Stoehr, et al. AIDS-related B-cell lymphoma (ARL): correlation of prognosis with differentiation profiles assessed by immunophenotyping Blood, September 1, 2005; 106(5): 1762 - 1769. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Rust, G Harms, T Blokzijl, M Boot, A Diepstra, J Kluiver, L Visser, S-C Peh, M Lim, W A Kamps, et al. High expression of Mcl-1 in ALK positive and negative anaplastic large cell lymphoma J. Clin. Pathol., May 1, 2005; 58(5): 520 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Swanson, S. L. Kuslak, W. Fang, L. Tze, P. Gaffney, S. Selby, K. L. Hippen, G. Nunez, C. L. Sidman, and T. W. Behrens Fatal Acute Lymphoblastic Leukemia in Mice Transgenic for B Cell-Restricted bcl-xL and c-myc J. Immunol., June 1, 2004; 172(11): 6684 - 6691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Linden, N. Kirchhof, C. Carlson, and B. Van Ness Targeted overexpression of Bcl-XL in B-lymphoid cells results in lymphoproliferative disease and plasma cell malignancies Blood, April 1, 2004; 103(7): 2779 - 2786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Little, S. Pittaluga, N. Grant, S. M. Steinberg, M. F. Kavlick, H. Mitsuya, G. Franchini, M. Gutierrez, M. Raffeld, E. S. Jaffe, et al. Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology Blood, June 15, 2003; 101(12): 4653 - 4659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Falini and D. Y. Mason Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry Blood, January 15, 2002; 99(2): 409 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kahnt, K. Matz-Rensing, P. Hofmann, C. Stahl-Hennig, and F.-J. Kaup SIV-associated Lymphomas in Rhesus Monkeys (Macaca mulatta) in Comparison with HIV-associated Lymphomas Vet. Pathol., January 1, 2002; 39(1): 42 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Z. Rassidakis, A. H. Sarris, M. Herling, R. J. Ford, F. Cabanillas, T. J. McDonnell, and L. J. Medeiros Differential Expression of BCL-2 Family Proteins in ALK-Positive and ALK-Negative Anaplastic Large Cell Lymphoma of T/Null-Cell Lineage Am. J. Pathol., August 1, 2001; 159(2): 527 - 535. [Abstract] [Full Text]
|
|
|
|
|
|
C. Villalva, F. Bougrine, G. Delsol, and P. Brousset Bcl-2 Expression in Anaplastic Large Cell Lymphoma Am. J. Pathol., May 1, 2001; 158(5): 1889 - 1890. [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Lee, J.-P. Cai, V. Deyev, P. S. Gill, L. Cabral, C. Wood, R. P. Agarwal, W. Xia, L. H. Boise, E. Podack, et al. Azidothymidine and Interferon-{{alpha}} Induce Apoptosis in Herpesvirus-associated Lymphomas Cancer Res., November 1, 1999; 59(21): 5514 - 5520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Bairey, Y. Zimra, M. Shaklai, E. Okon, and E. Rabizadeh Bcl-2, Bcl-X, Bax, and Bak Expression in Short- and Long-Lived Patients with Diffuse Large B-Cell Lymphomas Clin. Cancer Res., October 1, 1999; 5(10): 2860 - 2866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Castanos-Velez, T. Heiden, M. Ekman, J. Lawrence, G. Biberfeld, and P. Biberfeld Proliferation and Apoptosis-Related Gene Expression in Experimental Acquired Immunodeficiency Syndrome-Related Simian Lymphoma Blood, February 15, 1999; 93(4): 1364 - 1371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Soini, P. Paakko, and V-P. Lehto Histopathological Evaluation of Apoptosis in Cancer Am. J. Pathol., October 1, 1998; 153(4): 1041 - 1053. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
