| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 149, 429-437, Copyright © 1996 by American Society for Investigative Pathology
REGULAR ARTICLES |
K Higaki, H Yano and M Kojiro
First Department of Pathology, Kurume University School of Medicine, Japan.
Apoptosis, a programmed cell death, can be observed in the tissues of viral or autoimmune hepatitis and of hepatocellular carcinoma. Fas antigen (Fas) was proposed as a protein that triggers apoptosis. To elucidate the relationship between Fas expression and its location in hepatocellular carcinoma cells, we histochemically examined Fas expression by using 25 hepatocellular carcinoma tissues and their corresponding noncancerous tissues, which were surgically obtained from the same patients. In addition, the relationship between Fas expression and apoptotic cell numbers was examined in the hematoxylin-and-eosin- stained specimens obtained from 23 of the 25 patients. Hepatocellular carcinoma tissues expressed Fas less frequently and more weakly than noncancerous tissues. The majority of noncancerous specimens expressed Fas both on the surface and in the cytoplasm, whereas the majority of hepatocellular carcinoma expressed Fas only in the cytoplasm. Apoptotic cell counts were significantly higher in Fas-expressing tissues than in Fas-negative tissues. Among Fas-expressing tissues, the counts were higher in surface Fas-expressing tissues than in tissues that expressed only cytoplasmic Fas (P < 0.01 to 0.05). Our findings indicate that the development of apoptosis in hepatocellular carcinoma tissues relates to not only Fas expression but also its location.
This article has been cited by other articles:
 |
|
 |
|
  C. Kuntzen, N. Sonuc, E. N. De Toni, C. Opelz, S. R. Mucha, A. L. Gerbes, and S. T. Eichhorst Inhibition of c-Jun-N-terminal-Kinase Sensitizes Tumor Cells to CD95-Induced Apoptosis and Induces G2/M Cell Cycle Arrest Cancer Res., August 1, 2005; 65(15): 6780 - 6788. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M E Guicciardi and G J Gores Apoptosis: a mechanism of acute and chronic liver injury Gut, July 1, 2005; 54(7): 1024 - 1033. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ruiz-Ruiz, G. Robledo, E. Cano, J. M. Redondo, and A. Lopez-Rivas Characterization of p53-mediated Up-regulation of CD95 Gene Expression upon Genotoxic Treatment in Human Breast Tumor Cells J. Biol. Chem., August 22, 2003; 278(34): 31667 - 31675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ethier, V.-A. Raymond, L. Musallam, R. Houle, and M. Bilodeau Antiapoptotic effect of EGF on mouse hepatocytes associated with downregulation of proapoptotic Bid protein Am J Physiol Gastrointest Liver Physiol, July 7, 2003; 285(2): G298 - G308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. H. Igney and P. H. Krammer Immune escape of tumors: apoptosis resistance and tumor counterattack J. Leukoc. Biol., June 1, 2002; 71(6): 907 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Musallam, C. Ethier, P. S. Haddad, and M. Bilodeau Role of EGF receptor tyrosine kinase activity in antiapoptotic effect of EGF on mouse hepatocytes Am J Physiol Gastrointest Liver Physiol, June 1, 2001; 280(6): G1360 - G1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. d. L. Coste, A. Mignon, M. Fabre, E. Gilbert, A. Porteu, T. V. Dyke, A. Kahn, and C. Perret Paradoxical Inhibition of c-myc-induced Carcinogenesis by Bcl-2 in Transgenic Mice Cancer Res., October 1, 1999; 59(19): 5017 - 5022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Andre, D. Couton, J. Gaston, L. Erraji, L. Renia, P. Varlet, P. Briand, and J.-G. Guillet beta 2-Adrenergic receptor-selective agonist clenbuterol prevents Fas-induced liver apoptosis and death in mice Am J Physiol Gastrointest Liver Physiol, March 1, 1999; 276(3): G647 - G654. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
