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American Journal of Pathology, Vol 149, 665-674, Copyright © 1996 by American Society for Investigative Pathology

REGULAR ARTICLES

T cell subsets in normal human epidermis

AL Spetz, J Strominger and V Groh-Spies
Division of Tumor Virology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.

Freshly isolated human lymphocytes from normal epidermis were characterized with respect to distribution of subsets. The major T cell receptor-alpha beta + compartment was enriched for CD4+, for CD8 alpha alpha +, and for CD4-CD8-T lymphocytes compared with peripheral blood lymphocytes. Furthermore, the majority of epidermal T lymphocytes expressed a CD45RA- CD45ROhigh Fas+ memory/effector phenotype; many also expressed early-intermediate activation markers, suggesting antigenic exposure in vivo. The cutaneous lymphocyte-associated antigen was expressed by almost all epidermal T lymphocytes. A large portion also expressed the mucosal-associated alpha e beta 7-integrin, which may mediate retention to epithelium. These data show that T lymphocytes present in normal human epidermis constitute a distinct T cells compartment with characteristics similar to that of other epithelial- associated T cell compartments.

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