help button home button Am J Pathol International Conference on Pathology of Chest Diseases
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bardales, R. H.
Right arrow Articles by Hsu, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bardales, R. H.
Right arrow Articles by Hsu, S. M.

American Journal of Pathology, Vol 149, 845-852, Copyright © 1996 by American Society for Investigative Pathology

REGULAR ARTICLES

Apoptosis is a major pathway responsible for the resolution of type II pneumocytes in acute lung injury

RH Bardales, SS Xie, RF Schaefer and SM Hsu
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA.

Proliferation of type II pneumocytes has been linked to a repair process during the early phase of acute lung injury, and it persists for a variable period. The mechanisms responsible for their dissolution and/or disappearance are not known, but we speculate that it may be partly due to apoptosis. Sections of lung tissue from patients with acute lung injury (n = 7) and chronic interstitial pneumonia (n = 14) were stained for detection of apoptotic cells via specific labeling of nuclear DNA fragmentation. Results were correlated with those of proliferating cell nuclear antigen (PCNA) staining for cell proliferation. Marked apoptosis of CD68-negative type II pneumocytes (30 to 80%) was detected in four of the seven (57%) cases of acute lung injury. In these cases, representing the resolution phase of acute lung injury, PCNA positivity in pneumocytes was extremely rare. In the 3 other cases in the acute/proliferative phase, apoptotic type II pneumocytes were rare whereas PCNA expression was quite evident in these cells. In chronic interstitial pneumonia, only rare type II pneumocytes (< 5%) exhibited apoptosis, and they showed variable staining for PCNA (up to 70%). We conclude that proliferation of type II pneumocytes occurs during the early phase of acute lung injury and is of variable extent and duration. In the resolution phase of acute lung injury, extensive apoptosis of type II pneumocytes is largely responsible for the disappearance of these cells. The time frame within which the apoptotic response occurs is variable and is likely to be dependent upon the specific etiology and extent of the injury. In chronic interstitial pneumonia, type II pneumocytes proliferate continuously, although to a much lesser degree than in the early phase of acute lung injury, and are minimally apoptotic.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Perl, C.-S. Chung, U. Perl, J. Lomas-Neira, M. de Paepe, W. G. Cioffi, and A. Ayala
Fas-induced Pulmonary Apoptosis and Inflammation during Indirect Acute Lung Injury
Am. J. Respir. Crit. Care Med., September 15, 2007; 176(6): 591 - 601.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Deimling, K. Thompson, I. Tseu, J. Wang, R. Keijzer, A. K. Tanswell, and M. Post
Mesenchymal maintenance of distal epithelial cell phenotype during late fetal lung development
Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L725 - L741.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. B. Neff, B. R. Z'graggen, T. A. Neff, M. Jamnicki-Abegg, D. Suter, R. C. Schimmer, C. Booy, H. Joch, T. Pasch, P. A. Ward, et al.
Inflammatory response of tracheobronchial epithelial cells to endotoxin
Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L86 - L96.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
P. Russo, A. Catassi, A. Cesario, A. Imperatori, N. Rotolo, M. Fini, P. Granone, and L. Dominioni
Molecular Mechanisms of Hexavalent Chromium-Induced Apoptosis in Human Bronchoalveolar Cells
Am. J. Respir. Cell Mol. Biol., December 1, 2005; 33(6): 589 - 600.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Perl, C.-S. Chung, J. Lomas-Neira, T.-M. Rachel, W. L. Biffl, W. G. Cioffi, and A. Ayala
Silencing of Fas, but Not Caspase-8, in Lung Epithelial Cells Ameliorates Pulmonary Apoptosis, Inflammation, and Neutrophil Influx after Hemorrhagic Shock and Sepsis
Am. J. Pathol., December 1, 2005; 167(6): 1545 - 1559.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
T. R. Martin, N. Hagimoto, M. Nakamura, and G. Matute-Bello
Apoptosis and Epithelial Injury in the Lungs
Proceedings of the ATS, October 1, 2005; 2(3): 214 - 220.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. E. De Paepe, Q. Mao, Y. Chao, J. L. Powell, L. P. Rubin, and S. Sharma
Hyperoxia-induced apoptosis and Fas/FasL expression in lung epithelial cells
Am J Physiol Lung Cell Mol Physiol, October 1, 2005; 289(4): L647 - L659.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. Suzuki, T. J. Moraes, E. Vachon, H. H. Ginzberg, T.-T. Huang, M. A. Matthay, M. D. Hollenberg, J. Marshall, C. A. G. McCulloch, M. T. H. Abreu, et al.
Proteinase-Activated Receptor-1 Mediates Elastase-Induced Apoptosis of Human Lung Epithelial Cells
Am. J. Respir. Cell Mol. Biol., September 1, 2005; 33(3): 231 - 247.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
D. E. Wesche, J. L. Lomas-Neira, M. Perl, C.-S. Chung, and A. Ayala
Leukocyte apoptosis and its significance in sepsis and shock
J. Leukoc. Biol., August 1, 2005; 78(2): 325 - 337.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. A. Beamer and A. Holian
Scavenger receptor class A type I/II (CD204) null mice fail to develop fibrosis following silica exposure
Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L186 - L195.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. E. Vlahakis and R. D. Hubmayr
Cellular Stress Failure in Ventilator-injured Lungs
Am. J. Respir. Crit. Care Med., June 15, 2005; 171(12): 1328 - 1342.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. Wang, L. Bowman, Y. Lu, Y. Rojanasakul, R. R. Mercer, V. Castranova, and M. Ding
Essential role of p53 in silica-induced apoptosis
Am J Physiol Lung Cell Mol Physiol, March 1, 2005; 288(3): L488 - L496.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
Y. Abadie, F. Bregeon, L. Papazian, F. Lange, B. Chailley-Heu, P. Thomas, P. Duvaldestin, S. Adnot, B. Maitre, and C. Delclaux
Decreased VEGF concentration in lung tissue and vascular injury during ARDS
Eur. Respir. J., January 1, 2005; 25(1): 139 - 146.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Mura, C. C. dos Santos, D. Stewart, and M. Liu
Vascular endothelial growth factor and related molecules in acute lung injury
J Appl Physiol, November 1, 2004; 97(5): 1605 - 1617.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
X. Li, R. Shu, G. Filippatos, and B. D. Uhal
Apoptosis in lung injury and remodeling
J Appl Physiol, October 1, 2004; 97(4): 1535 - 1542.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. Schmeck, R. Gross, P. D. N'Guessan, A. C. Hocke, S. Hammerschmidt, T. J. Mitchell, S. Rosseau, N. Suttorp, and S. Hippenstiel
Streptococcus pneumoniae-Induced Caspase 6-Dependent Apoptosis in Lung Epithelium
Infect. Immun., September 1, 2004; 72(9): 4940 - 4947.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. Geiser, M. Ishigaki, C. van Leer, M. A. Matthay, and V. C. Broaddus
H2O2 inhibits alveolar epithelial wound repair in vitro by induction of apoptosis
Am J Physiol Lung Cell Mol Physiol, August 1, 2004; 287(2): L448 - L453.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
I. Inoshima, K. Kuwano, N. Hamada, M. Yoshimi, T. Maeyama, N. Hagimoto, Y. Nakanishi, and N. Hara
Induction of CDK inhibitor p21 gene as a new therapeutic strategy against pulmonary fibrosis
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L727 - L733.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. C. Rudkowski, E. Barreiro, R. Harfouche, P. Goldberg, O. Kishta, P. D'Orleans-Juste, J. Labonte, O. Lesur, and S. N. A. Hussain
Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L793 - L800.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Hammerschmidt, H. Kuhn, T. Grasenack, C. Gessner, and H. Wirtz
Apoptosis and Necrosis Induced by Cyclic Mechanical Stretching in Alveolar Type II Cells
Am. J. Respir. Cell Mol. Biol., March 1, 2004; 30(3): 396 - 402.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
O. Lesur, M. Brisebois, A. Thibodeau, F. Chagnon, D. Lane, and T. Fullop
Role of IFN-{gamma} and IL-2 in rat lung epithelial cell migration and apoptosis after oxidant injury
Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L4 - L14.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. H. Hastings, R. A. Quintana, R. Sandoval, D. Duey, Y. Rascon, D. W. Burton, and L. J. Deftos
Proapoptotic Effects of Parathyroid Hormone-Related Protein in Type II Pneumocytes
Am. J. Respir. Cell Mol. Biol., December 1, 2003; 29(6): 733 - 742.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Nakajoh, T. Fukushima, T. Suzuki, M. Yamaya, K. Nakayama, K. Sekizawa, and H. Sasaki
Retinoic Acid Inhibits Elastase-Induced Injury in Human Lung Epithelial Cell Lines
Am. J. Respir. Cell Mol. Biol., March 1, 2003; 28(3): 296 - 304.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. H. Albertine, M. F. Soulier, Z. Wang, A. Ishizaka, S. Hashimoto, G. A. Zimmerman, M. A. Matthay, and L. B. Ware
Fas and Fas Ligand Are Up-Regulated in Pulmonary Edema Fluid and Lung Tissue of Patients with Acute Lung Injury and the Acute Respiratory Distress Syndrome
Am. J. Pathol., November 1, 2002; 161(5): 1783 - 1796.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. W. Kramer, S. Kramer, M. Ikegami, and A. H. Jobe
Injury, inflammation, and remodeling in fetal sheep lung after intra-amniotic endotoxin
Am J Physiol Lung Cell Mol Physiol, August 1, 2002; 283(2): L452 - L459.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Sanchez-Esteban, Y. Wang, L. A. Cicchiello, and L. P. Rubin
Pre- and Postnatal Lung Development, Maturation, and Plasticity: Cyclic mechanical stretch inhibits cell proliferation and induces apoptosis in fetal rat lung fibroblasts
Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L448 - L456.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. E. Dincer, N. Gangopadhyay, R. Wang, and B. D. Uhal
Norepinephrine induces alveolar epithelial apoptosis mediated by {alpha}-, {beta}-, and angiotensin receptor activation
Am J Physiol Lung Cell Mol Physiol, September 1, 2001; 281(3): L624 - L630.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. Matute-Bello, W. C. Liles, C. W. Frevert, M. Nakamura, K. Ballman, C. Vathanaprida, P. A. Kiener, and T. R. Martin
Recombinant human Fas ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits
Am J Physiol Lung Cell Mol Physiol, August 1, 2001; 281(2): L328 - L335.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. KASAHARA, R. M. TUDER, C. D. COOL, D. A. LYNCH, S. C. FLORES, and N. F. VOELKEL
Endothelial Cell Death and Decreased Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 in Emphysema
Am. J. Respir. Crit. Care Med., March 1, 2001; 163(3): 737 - 744.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Kuwano, R. Kunitake, T. Maeyama, N. Hagimoto, M. Kawasaki, T. Matsuba, M. Yoshimi, I. Inoshima, K. Yoshida, and N. Hara
Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor
Am J Physiol Lung Cell Mol Physiol, February 1, 2001; 280(2): L316 - L325.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. E. De Paepe, L. P. Rubin, C. Jude, A. M. Lesieur-Brooks, D. R. Mills, and F. I. Luks
Fas ligand expression coincides with alveolar cell apoptosis in late-gestation fetal lung development
Am J Physiol Lung Cell Mol Physiol, November 1, 2000; 279(5): L967 - L976.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Fine, Y. Janssen-Heininger, R. P. Soultanakis, S. G. Swisher, and B. D. Uhal
Apoptosis in lung pathophysiology
Am J Physiol Lung Cell Mol Physiol, September 1, 2000; 279(3): L423 - L427.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Behnia, K. A. Robertson, and W. J. Martin II
Lung Infections : Role of Apoptosis in Host Defense and Pathogenesis of Disease
Chest, June 1, 2000; 117(6): 1771 - 1777.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
U. Stammberger, A. Gaspert, S. Hillinger, P. Vogt, B. Odermatt, W. Weder, and R. A. Schmid
Apoptosis induced by ischemia and reperfusion in experimental lung transplantation
Ann. Thorac. Surg., May 1, 2000; 69(5): 1532 - 1536.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. Bargout, A. Jankov, E. Dincer, R. Wang, T. Komodromos, O. Ibarra-Sunga, G. Filippatos, and B. D. Uhal
Amiodarone induces apoptosis of human and rat alveolar epithelial cells in vitro
Am J Physiol Lung Cell Mol Physiol, May 1, 2000; 278(5): L1039 - L1044.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. Gotoh, K. Kambara, X.-W. Jiang, M. Ohno, S. Emura, T. Fujiwara, and H. Fujiwara
Apoptosis in microvascular endothelial cells of perfused rabbit lungs with acute hydrostatic edema
J Appl Physiol, February 1, 2000; 88(2): 518 - 526.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. Kuwano and N. Hara
Signal Transduction Pathways of Apoptosis and Inflammation Induced by the Tumor Necrosis Factor Receptor Family
Am. J. Respir. Cell Mol. Biol., February 1, 2000; 22(2): 147 - 149.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. HASHIMOTO, A. KOBAYASHI, K. KOOGUCHI, Y. KITAMURA, H. ONODERA, and H. NAKAJIMA
Upregulation of Two Death Pathways of Perforin/Granzyme and FasL/Fas in Septic Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., January 1, 2000; 161(1): 237 - 243.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. Wang, A. Zagariya, E. Ang, O. Ibarra-Sunga, and B. D. Uhal
Fas-induced apoptosis of alveolar epithelial cells requires ANG II generation and receptor interaction
Am J Physiol Lung Cell Mol Physiol, December 1, 1999; 277(6): L1245 - L1250.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Buckley, B. Driscoll, L. Barsky, K. Weinberg, K. Anderson, and D. Warburton
ERK activation protects against DNA damage and apoptosis in hyperoxic rat AEC2
Am J Physiol Lung Cell Mol Physiol, July 1, 1999; 277(1): L159 - L166.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. Wang, A. Zagariya, O. Ibarra-Sunga, C. Gidea, E. Ang, S. Deshmukh, G. Chaudhary, J. Baraboutis, G. Filippatos, and B. D. Uhal
Angiotensin II induces apoptosis in human and rat alveolar epithelial cells
Am J Physiol Lung Cell Mol Physiol, May 1, 1999; 276(5): L885 - L889.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y. M. W. Janssen, R. Soultanakis, K. Steece, E. Heerdt, R. J. Singh, J. Joseph, and B. Kalyanaraman
Depletion of nitric oxide causes cell cycle alterations, apoptosis, and oxidative stress in pulmonary cells
Am J Physiol Lung Cell Mol Physiol, December 1, 1998; 275(6): L1100 - L1109.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. D. Uhal, I. Joshi, W. F. Hughes, C. Ramos, A. Pardo, and M. Selman
Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung
Am J Physiol Lung Cell Mol Physiol, December 1, 1998; 275(6): L1192 - L1199.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. D. Uhal, C. Gidea, R. Bargout, A. Bifero, O. Ibarra-Sunga, M. Papp, K. Flynn, and G. Filippatos
Captopril inhibits apoptosis in human lung epithelial cells: a potential antifibrotic mechanism
Am J Physiol Lung Cell Mol Physiol, November 1, 1998; 275(5): L1013 - L1017.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. C. Schittny, V. Djonov, A. Fine, and P. H. Burri
Programmed Cell Death Contributes to Postnatal Lung Development
Am. J. Respir. Cell Mol. Biol., June 1, 1998; 18(6): 786 - 793.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. A. Jimenez, C. Zanella, H. Fung, Y. M. W. Janssen, P. Vacek, C. Charland, J. Goldberg, and B. T. Mossman
Role of extracellular signal-regulated protein kinases in apoptosis by asbestos and H2O2
Am J Physiol Lung Cell Mol Physiol, November 1, 1997; 273(5): L1029 - L1035.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. L. Goldberg, C. L. Zanella, Y. M. W. Janssen, C. R. Timblin, L. A. Jimenez, P. Vacek, D. J. Taatjes, and B. T. Mossman
Novel Cell Imaging Techniques Show Induction of Apoptosis and Proliferation in Mesothelial Cells by Asbestos
Am. J. Respir. Cell Mol. Biol., September 1, 1997; 17(3): 265 - 271.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. T. MOSSMAN and A. CHURG
Mechanisms in the Pathogenesis of Asbestosis and Silicosis
Am. J. Respir. Crit. Care Med., May 1, 1997; 157(5): 1666 - 1680.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the American Society for Investigative Pathology.