| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 149, 1119-1127, Copyright © 1996 by American Society for Investigative Pathology
REGULAR ARTICLES |
HY Lan, W Mu, N Yang, A Meinhardt, DJ Nikolic-Paterson, YY Ng, M Bacher, RC Atkins and R Bucala
Department of Nephrology, Monash Medical Centre, Clayton, Australia.
Macrophage migration inhibitory factor (MIF), a key mediator of the delayed-type hypersensitivity response, was originally thought to be produced by activated T cells. However, recent studies have found that MIF is produced in many cell types including monocytes/macrophages and anterior pituitary cells. The current study has examined MIF expression in normal and diseased kidney using in situ hybridization, immunohistochemistry, and Northern blotting. MIF mRNA and protein are constitutively expressed in normal kidney, being largely restricted to tubular epithelial cells and some glomerular visceral and parietal epithelial cells. During the development of rat anti-glomerular basement membrane glomerulonephritis, a model of macrophage-mediated renal injury, there was marked de novo expression of MIF by intrinsic kidney cells including endothelium and glomerular and tubular epithelial cells. Up-regulation of MIF expression correlated with macrophage accumulation within the glomerulus (P < 0.001) and tubulointerstitium (P < 0.001). Of significance, the accumulation of macrophages was exclusively localized to areas of strong MIF expression, contributing to focal glomerular and tubulointerstitial lesion formation. In addition, up-regulation of MIF expression by parietal epithelial cells was associated with macrophage accumulation within Bowman's space and crescent formation. Combined in situ hybridization and immunostaining also demonstrated MIF expression by macrophages, T cells, and fibroblast-like cells within renal lesions. In conclusion, these data provide the first demonstration that renal epithelial cells are a major source of MIF in both normal and diseased kidney. Furthermore, the up-regulation of MIF expression may play an important role in macrophage accumulation and progressive renal injury in rat crescentic glomerulonephritis.
This article has been cited by other articles:
 |
|
 |
|
  A. Y. Hoi, M. J. Hickey, P. Hall, J. Yamana, K. M. O'Sullivan, L. L. Santos, W. G. James, A. R. Kitching, and E. F. Morand Macrophage Migration Inhibitory Factor Deficiency Attenuates Macrophage Recruitment, Glomerulonephritis, and Lethality in MRL/lpr Mice J. Immunol., October 15, 2006; 177(8): 5687 - 5696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kudrin, M. Scott, S. Martin, C.-w. Chung, R. Donn, A. McMaster, S. Ellison, D. Ray, K. Ray, and M. Binks Human Macrophage Migration Inhibitory Factor: A PROVEN IMMUNOMODULATORY CYTOKINE? J. Biol. Chem., October 6, 2006; 281(40): 29641 - 29651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Cvetkovic, Y. Al-Abed, D. Miljkovic, D. Maksimovic-Ivanic, J. Roth, M. Bacher, H. Y. Lan, F. Nicoletti, and S. Stosic-Grujicic Critical Role of Macrophage Migration Inhibitory Factor Activity in Experimental Autoimmune Diabetes Endocrinology, July 1, 2005; 146(7): 2942 - 2951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. K. Leung, L. Y. Y. Chan, A. W. L. Tsang, E. W. L. Liu, M. F. Lam, S. C. W. Tang, and K. N. Lai Anti-macrophage migration inhibitory factor reduces transforming growth factor-{beta}1 expression in experimental IgA nephropathy Nephrol. Dial. Transplant., August 1, 2004; 19(8): 1976 - 1985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Razzaque, C. S. Foster, and A. R. Ahmed Role of Macrophage Migration Inhibitory Factor in Conjunctival Pathology in Ocular Cicatricial Pemphigoid Invest. Ophthalmol. Vis. Sci., April 1, 2004; 45(4): 1174 - 1181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Watanabe, T. Shimizu, J. Nishihira, R. Abe, T. Nakayama, M. Taniguchi, H. Sabe, T. Ishibashi, and H. Shimizu Ultraviolet A-induced Production of Matrix Metalloproteinase-1 Is Mediated by Macrophage Migration Inhibitory Factor (MIF) in Human Dermal Fibroblasts J. Biol. Chem., January 16, 2004; 279(3): 1676 - 1683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-M. Yu, K. W.-H. Lai, Y.-X. Chen, X.-R. Huang, and H. Y. Lan Expression of Macrophage Migration Inhibitory Factor in Acute Ischemic Myocardial Injury J. Histochem. Cytochem., May 1, 2003; 51(5): 625 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bacher, J. Schrader, N. Thompson, K. Kuschela, D. Gemsa, G. Waeber, and J. Schlegel Up-Regulation of Macrophage Migration Inhibitory Factor Gene and Protein Expression in Glial Tumor Cells during Hypoxic and Hypoglycemic Stress Indicates a Critical Role for Angiogenesis in Glioblastoma Multiforme Am. J. Pathol., January 1, 2003; 162(1): 11 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Fingerle-Rowson, P. Koch, R. Bikoff, X. Lin, C. N. Metz, F. S. Dhabhar, A. Meinhardt, and R. Bucala Regulation of Macrophage Migration Inhibitory Factor Expression by Glucocorticoids in Vivo Am. J. Pathol., January 1, 2003; 162(1): 47 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Lubetsky, A. Dios, J. Han, B. Aljabari, B. Ruzsicska, R. Mitchell, E. Lolis, and Y. Al-Abed The Tautomerase Active Site of Macrophage Migration Inhibitory Factor Is a Potential Target for Discovery of Novel Anti-inflammatory Agents J. Biol. Chem., July 5, 2002; 277(28): 24976 - 24982. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. G. Brown, D. J. Nikolic-Paterson, P. A. Hill, N. M. Isbel, J. Dowling, C. M. Metz, and R. C. Atkins Urine Macrophage Migration Inhibitory Factor Reflects the Severity of Renal Injury in Human Glomerulonephritis J. Am. Soc. Nephrol., January 1, 2002; 13(90001): S7 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-G. Lin, X.-Y. Yu, Y.-X. Chen, X. R. Huang, C. Metz, R. Bucala, C.-P. Lau, and H. Y. Lan De Novo Expression of Macrophage Migration Inhibitory Factor in Atherogenesis in Rabbits Circ. Res., December 8, 2000; 87(12): 1202 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. TOMITA, R. MORISHITA, H. Y. LAN, K. YAMAMOTO, M. HASHIZUME, M. NOTAKE, K. TOYOSAWA, B. FUJITANI, W. MU, D. J. NIKOLIC-PATERSON, et al. In Vivo Administration of a Nuclear Transcription Factor-{kappa}B Decoy Suppresses Experimental Crescentic Glomerulonephritis J. Am. Soc. Nephrol., July 1, 2000; 11(7): 1244 - 1252. [Abstract] [Full Text]
|
|
|
|
|
|
N. Suzuki, J. Ishizaki, Y. Yokota, K.-i. Higashino, T. Ono, M. Ikeda, N. Fujii, K. Kawamoto, and K. Hanasaki Structures, Enzymatic Properties, and Expression of Novel Human and Mouse Secretory Phospholipase A2s J. Biol. Chem., February 25, 2000; 275(8): 5785 - 5793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. V. Pastrana, N. Raghavan, P. FitzGerald, S. W. Eisinger, C. Metz, R. Bucala, R. P. Schleimer, C. Bickel, and A. L. Scott Filarial Nematode Parasites Secrete a Homologue of the Human Cytokine Macrophage Migration Inhibitory Factor Infect. Immun., December 1, 1998; 66(12): 5955 - 5963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shimizu, T. Kuroda, M. Ikeda, S. Hata, and M. Fujimoto Potential Contribution of Endothelin to Renal Abnormalities in Glycerol-Induced Acute Renal Failure in Rats J. Pharmacol. Exp. Ther., August 1, 1998; 286(2): 977 - 983. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. Waeber, T. Calandra, R. Roduit, J.-A. Haefliger, C. Bonny, N. Thompson, B. Thorens, E. Temler, A. Meinhardt, M. Bacher, et al. Insulin secretion is regulated by the glucose-dependent production of islet beta cell macrophage migration inhibitory factor PNAS, April 29, 1997; 94(9): 4782 - 4787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Y. Lan, M. Bacher, N. Yang, W. Mu, D. J. Nikolic-Paterson, C. Metz, A. Meinhardt, R. Bucala, and R. C. Atkins The Pathogenic Role of Macrophage Migration Inhibitory Factor in Immunologically Induced Kidney Disease in the Rat J. Exp. Med., April 21, 1997; 185(8): 1455 - 1466. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
