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American Journal of Pathology, Vol 150, 901-910, Copyright © 1997 by American Society for Investigative Pathology

REGULAR ARTICLES

HMGI(Y) activation by chromosome 6p21 rearrangements in multilineage mesenchymal cells from pulmonary hamartoma

S Xiao, ML Lux, R Reeves, TJ Hudson and JA Fletcher
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

The chromosome band 6p21 high-mobility group gene, HMGI(Y), encodes DNA- binding proteins with both chromatin structural and gene regulatory roles. Although HMGI(Y) expression is associated with neoplastic transformation, no oncogenic HMGI(Y) mutations have been identified. We report pulmonary chondroid hamartoma chromosome 6p21 aberrations targeting HMGI(Y). Several pulmonary chondroid hamartomas had chromosome rearrangements mapping within 100 kb of HMGI(Y), and one pulmonary chondroid hamartoma contained an intragenic fusion juxtaposing HMGI(Y) A.T book DNA-binding domains with a laminin alpha 4 chain epidermal-growth-factor-like/ zinc-finger-like motif. These findings demonstrate an oncogenic role for HMGI(Y) and for laminin chain transcriptional regulatory motifs.


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Copyright © 1997 by the American Society for Investigative Pathology.