| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 150, 929-938, Copyright © 1997 by American Society for Investigative Pathology
REGULAR ARTICLES |
S Uccini, MC Sirianni, L Vincenzi, S Topino, A Stoppacciaro, I Lesnoni La Parola, M Capuano, C Masini, D Cerimele, M Cella, A Lanzavecchia, P Allavena, A Mantovani, CD Baroni and LP Ruco
Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Italy.
The mannose receptor (MR) is a surface 175-kd C-type lectin expressed by macrophages and dendritic cells. MR is involved in removal of effete cells, phagocytosis of mannose-coated particles, pinocytosis, and antigen presentation. Expression of MR was investigated in 17 biopsies of Kaposi's sarcoma (3 AIDS KS, 13 classical KS, and 1 transplant- associated KS) using three anti-MR monoclonal antibodies (3.29, D547, and PAM1). Immunostaining for MR was detected in 94 +/- 7% KS cells with spindle morphology. In normal tissues, MR was expressed by sinus- lining cells of spleen and lymph nodes, but it was not detected in endothelial cells lining normal hematic and lymphatic vessels, hemangioma, hemangioendothelioma, and lymphangioma. Expression of MR in KS cells prompted us to investigate the possibility that they derive from a circulating precursor cell. Peripheral blood mononuclear cells from 16 patients with KS (10 classical, 1 transplanted, and 5 AIDS) were cultured in PHA-conditioned medium for 10 to 14 days. Confluent monolayers of adherent spindle cells were detected in 8 of 11 classical KS, in 5 of 5 AIDS KS patients, and in 0 of 34 control patients. Peripheral-blood-derived KS-like cells were characterized by co- expression of macrophage and endothelial antigens being positive for CD45 (60%), CD68 (98%), MR (70%), CD14 (25%), VE-cadherin (70%), and von Willebrand factor (10%). When the immunophenotype of peripheral- blood-derived adherent cells was compared with that of KS spindle cells of tissue biopsies, it was found that both cell types are VE- cadherin+/MR+/CD68+, that peripheral-blood-derived spindle cells are CD34- and are less frequently stained for CD31 and von Willebrand factor, and that lesional KS cells do not express the leukocyte markers CD45 and CD18. Our findings are consistent with the possibility that KS lesions derive from tissue accumulation and local proliferation of a special subset of macrophages with endothelial features the normal counterpart of which are the sinus-lining cells of spleen and lymph nodes.
This article has been cited by other articles:
 |
|
 |
|
  M. Mansouri, P. P. Rose, A. V. Moses, and K. Fruh Remodeling of Endothelial Adherens Junctions by Kaposi's Sarcoma-Associated Herpesvirus J. Virol., October 1, 2008; 82(19): 9615 - 9628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-Z. He, A. Crocker, J. Lee, J. Mendoza-Ramirez, X.-T. Wang, L. A. Vitale, T. O'Neill, C. Petromilli, H.-F. Zhang, J. Lopez, et al. Antigenic Targeting of the Human Mannose Receptor Induces Tumor Immunity J. Immunol., May 15, 2007; 178(10): 6259 - 6267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Le Cabec, L. J. Emorine, I. Toesca, C. Cougoule, and I. Maridonneau-Parini The human macrophage mannose receptor is not a professional phagocytic receptor J. Leukoc. Biol., June 1, 2005; 77(6): 934 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Boccellino, G. Camussi, A. Giovane, L. Ferro, V. Calderaro, C. Balestrieri, and L. Quagliuolo Platelet-Activating Factor Regulates Cadherin-Catenin Adhesion System Expression and {beta}-Catenin Phosphorylation during Kaposi's Sarcoma Cell Motility Am. J. Pathol., May 1, 2005; 166(5): 1515 - 1522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Laskarin, K. Cupurdija, V. S. Tokmadzic, D. Dorcic, J. Dupor, K. Juretic, N. Strbo, T. B. Crncic, F. Marchezi, P. Allavena, et al. The presence of functional mannose receptor on macrophages at the maternal-fetal interface Hum. Reprod., April 1, 2005; 20(4): 1057 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. H. Parsons, B. Szomju, and D. H. Kedes Susceptibility of human fetal mesencyhmal stem cells to Kaposi sarcoma-associated herpesvirus Blood, November 1, 2004; 104(9): 2736 - 2738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Monti, B. E. Leone, A. Zerbi, G. Balzano, S. Cainarca, V. Sordi, M. Pontillo, A. Mercalli, V. Di Carlo, P. Allavena, et al. Tumor-Derived MUC1 Mucins Interact with Differentiating Monocytes and Induce IL-10highIL-12low Regulatory Dendritic Cell J. Immunol., June 15, 2004; 172(12): 7341 - 7349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Romani, C. Montagnoli, S. Bozza, K. Perruccio, A. Spreca, P. Allavena, S. Verbeek, R. A. Calderone, F. Bistoni, and P. Puccetti The exploitation of distinct recognition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans Int. Immunol., January 1, 2004; 16(1): 149 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Chieppa, G. Bianchi, A. Doni, A. Del Prete, M. Sironi, G. Laskarin, P. Monti, L. Piemonti, A. Biondi, A. Mantovani, et al. Cross-Linking of the Mannose Receptor on Monocyte-Derived Dendritic Cells Activates an Anti-Inflammatory Immunosuppressive Program J. Immunol., November 1, 2003; 171(9): 4552 - 4560. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Dourmishev, A. L. Dourmishev, D. Palmeri, R. A. Schwartz, and D. M. Lukac Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis Microbiol. Mol. Biol. Rev., June 1, 2003; 67(2): 175 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Samaniego, D. Young, C. Grimes, V. Prospero, M. Christofidou-Solomidou, H. M. DeLisser, O. Prakash, A. A. Sahin, and S. Wang Vascular Endothelial Growth Factor and Kaposi's Sarcoma Cells in Human Skin Grafts Cell Growth Differ., August 1, 2002; 13(8): 387 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bozza, R. Gaziano, A. Spreca, A. Bacci, C. Montagnoli, P. di Francesco, and L. Romani Dendritic Cells Transport Conidia and Hyphae of Aspergillus fumigatus from the Airways to the Draining Lymph Nodes and Initiate Disparate Th Responses to the Fungus J. Immunol., February 1, 2002; 168(3): 1362 - 1371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Irjala, E.-L. Johansson, R. Grenman, K. Alanen, M. Salmi, and S. Jalkanen Mannose Receptor Is a Novel Ligand for L-Selectin and Mediates Lymphocyte Binding to Lymphatic Endothelium J. Exp. Med., October 8, 2001; 194(8): 1033 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Reiling, A. Blumenthal, H.-D. Flad, M. Ernst, and S. Ehlers Mycobacteria-Induced TNF-{alpha} and IL-10 Formation by Human Macrophages Is Differentially Regulated at the Level of Mitogen-Activated Protein Kinase Activity J. Immunol., September 15, 2001; 167(6): 3339 - 3345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Keisari, H. Wang, A. Mesika, R. Matatov, L. Nissimov, E. Crouch, and I. Ofek Surfactant protein D-coated Klebsiella pneumoniae stimulates cytokine production in mononuclear phagocytes J. Leukoc. Biol., July 1, 2001; 70(1): 135 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Groger, W. Holnthoner, D. Maurer, S. Lechleitner, K. Wolff, B. B. Mayr, W. Lubitz, and P. Petzelbauer Dermal Microvascular Endothelial Cells Express the 180-kDa Macrophage Mannose Receptor In Situ and In Vitro J. Immunol., November 15, 2000; 165(10): 5428 - 5434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Abrams, S. L. Kelley, E. Hayes, T. Kikuchi, M. J. Brown, S. Kang, M. G. Lebwohl, C. A. Guzzo, B. V. Jegasothy, P. S. Linsley, et al. Blockade of T Lymphocyte Costimulation with Cytotoxic T Lymphocyte-associated Antigen 4-Immunoglobulin (CTLA4Ig) Reverses the Cellular Pathology of Psoriatic Plaques, Including the Activation of Keratinocytes, Dendritic Cells, and Endothelial Cells J. Exp. Med., September 5, 2000; 192(5): 681 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Piemonti, P. Monti, M. Sironi, P. Fraticelli, B. E. Leone, E. Dal Cin, P. Allavena, and V. Di Carlo Vitamin D3 Affects Differentiation, Maturation, and Function of Human Monocyte-Derived Dendritic Cells J. Immunol., May 1, 2000; 164(9): 4443 - 4451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Aboulafia The Epidemiologic, Pathologic, and Clinical Features of AIDS-Associated Pulmonary Kaposi’s Sarcoma Chest, April 1, 2000; 117(4): 1128 - 1145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Jordens, A. Thompson, R. Amons, and F. Koning Human dendritic cells shed a functional, soluble form of the mannose receptor Int. Immunol., November 1, 1999; 11(11): 1775 - 1780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Romagnani, A. De Paulis, C. Beltrame, F. Annunziato, V. Dente, E. Maggi, S. Romagnani, and G. Marone Tryptase-Chymase Double-Positive Human Mast Cells Express the Eotaxin Receptor CCR3 and Are Attracted by CCR3-Binding Chemokines Am. J. Pathol., October 1, 1999; 155(4): 1195 - 1204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chantry, P. Romagnani, C. J. Raport, C. L. Wood, A. Epp, S. Romagnani, and P. W. Gray Macrophage-Derived Chemokine Is Localized to Thymic Medullary Epithelial Cells and Is a Chemoattractant for CD3+, CD4+, CD8low Thymocytes Blood, September 15, 1999; 94(6): 1890 - 1898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Piemonti, P. Monti, P. Allavena, B. E. Leone, A. Caputo, and V. Di Carlo Glucocorticoids increase the endocytic activity of human dendritic cells Int. Immunol., September 1, 1999; 11(9): 1519 - 1526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Linehan, L. Martinez-Pomares, P. D. Stahl, and S. Gordon Mannose Receptor and Its Putative Ligands in Normal Murine Lymphoid and Nonlymphoid Organs: In Situ Expression of Mannose Receptor by Selected Macrophages, Endothelial Cells, Perivascular Microglia, and Mesangial Cells, but not Dendritic Cells J. Exp. Med., June 21, 1999; 189(12): 1961 - 1972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Monini, S. Colombini, M. Sturzl, D. Goletti, A. Cafaro, C. Sgadari, S. Butto, M. Franco, P. Leone, S. Fais, et al. Reactivation and Persistence of Human Herpesvirus-8 Infection in B Cells and Monocytes by Th-1 Cytokines Increased in Kaposi's Sarcoma Blood, June 15, 1999; 93(12): 4044 - 4058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Monini, F. Carlini, M. Stürzl, P. Rimessi, F. Superti, M. Franco, G. Melucci-Vigo, A. Cafaro, D. Goletti, C. Sgadari, et al. Alpha Interferon Inhibits Human Herpesvirus 8 (HHV-8) Reactivation in Primary Effusion Lymphoma Cells and Reduces HHV-8 Load in Cultured Peripheral Blood Mononuclear Cells J. Virol., May 1, 1999; 73(5): 4029 - 4041. [Abstract] [Full Text]
|
|
|
|
|
|
M. C. Sirianni, L. Vincenzi, V. Fiorelli, S. Topino, E. Scala, S. Uccini, A. Angeloni, A. Faggioni, D. Cerimele, F. Cottoni, et al. gamma -Interferon Production in Peripheral Blood Mononuclear Cells and Tumor Infiltrating Lymphocytes From Kaposi's Sarcoma Patients: Correlation With the Presence of Human Herpesvirus-8 in Peripheral Blood Mononuclear Cells and Lesional Macrophages Blood, February 1, 1998; 91(3): 968 - 976. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
