This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Smith, T. Articles by Cuzner, M. L. Search for Related Content PubMed PubMed Citation Articles by Smith, T. Articles by Cuzner, M. L.

American Journal of Pathology, Vol 150, 1909-1917, Copyright © 1997 by American Society for Investigative Pathology

REGULAR ARTICLES

Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat

T Smith, AK Hewson, CI Kingsley, JP Leonard and ML Cuzner
Miriam Marks Department of Neurochemistry, Institute of Neurology, London, United Kingdom.

Acute, monophasic experimental allergic encephalomyelitis (EAE) in the Lewis rat shows pathological similarities to the human disease multiple sclerosis (MS). Rats that recover from EAE are essentially resistant to disease reinduction, unlike MS in which relapses are frequently associated with common bacterial and viral infections. As macrophage- derived interleukin (IL)-12 is a critical component of innate resistance to bacterial infection and appears to directly activate encephalitogenic T cells in vivo, the ability of this cytokine to reinduce paralysis in EAE was examined. Paralytic disease was exacerbated by intraperitoneal IL-12 administration and could be reinduced up to 1 week after recovery from the primary clinical episode. Concomitant with worsening of initial clinical signs and relapse was an increase in the ratio of macrophages to T cells in brain stem perivascular cuffs and the expression of inducible nitric oxide synthase in cells with both macrophage and microglial morphology. These findings suggest that IL-12 may contribute to macrophage-mediated disease exacerbation and relapse in patients with MS.

This article has been cited by other articles:

				S. Sinha, L. J. Kaler, T. M. Proctor, C. Teuscher, A. A. Vandenbark, and H. Offner IL-13-Mediated Gender Difference in Susceptibility to Autoimmune Encephalomyelitis J. Immunol., February 15, 2008; 180(4): 2679 - 2685. [Abstract] [Full Text] [PDF]

				P. Thakker, M. W. Leach, W. Kuang, S. E. Benoit, J. P. Leonard, and S. Marusic IL-23 Is Critical in the Induction but Not in the Effector Phase of Experimental Autoimmune Encephalomyelitis J. Immunol., February 15, 2007; 178(4): 2589 - 2598. [Abstract] [Full Text] [PDF]

				W. Hu, T. Dehmel, J. Pirhonen, H.-P. Hartung, and B. C. Kieseier Interleukin 23 in acute inflammatory demyelination of the peripheral nerve. Arch Neurol, June 1, 2006; 63(6): 858 - 864. [Abstract] [Full Text] [PDF]

				S. B. Conant and R. H. Swanborg Autoreactive T Cells Persist in Rats Protected against Experimental Autoimmune Encephalomyelitis and Can Be Activated through Stimulation of Innate Immunity J. Immunol., May 1, 2004; 172(9): 5322 - 5328. [Abstract] [Full Text] [PDF]

				G.-X. Zhang, B. Gran, S. Yu, J. Li, I. Siglienti, X. Chen, M. Kamoun, and A. Rostami Induction of Experimental Autoimmune Encephalomyelitis in IL-12 Receptor-{beta}2-Deficient Mice: IL-12 Responsiveness Is Not Required in the Pathogenesis of Inflammatory Demyelination in the Central Nervous System J. Immunol., February 15, 2003; 170(4): 2153 - 2160. [Abstract] [Full Text] [PDF]

				B. Gran, G.-X. Zhang, S. Yu, J. Li, X.-H. Chen, E. S. Ventura, M. Kamoun, and A. Rostami IL-12p35-Deficient Mice Are Susceptible to Experimental Autoimmune Encephalomyelitis: Evidence for Redundancy in the IL-12 System in the Induction of Central Nervous System Autoimmune Demyelination J. Immunol., December 15, 2002; 169(12): 7104 - 7110. [Abstract] [Full Text] [PDF]

				H. P. M. Brok, M. van Meurs, E. Blezer, A. Schantz, D. Peritt, G. Treacy, J. D. Laman, J. Bauer, and B. A. 't Hart Prevention of Experimental Autoimmune Encephalomyelitis in Common Marmosets Using an Anti-IL-12p40 Monoclonal Antibody J. Immunol., December 1, 2002; 169(11): 6554 - 6563. [Abstract] [Full Text] [PDF]

				Z. Ahmed, A. I. Doward, G. Pryce, D. L. Taylor, J. M. Pocock, J. P. Leonard, D. Baker, and M. L. Cuzner A Role for Caspase-1 and -3 in the Pathology of Experimental Allergic Encephalomyelitis : Inflammation Versus Degeneration Am. J. Pathol., November 1, 2002; 161(5): 1577 - 1586. [Abstract] [Full Text] [PDF]

				C. Natarajan and J. J. Bright Curcumin Inhibits Experimental Allergic Encephalomyelitis by Blocking IL-12 Signaling Through Janus Kinase-STAT Pathway in T Lymphocytes J. Immunol., June 15, 2002; 168(12): 6506 - 6513. [Abstract] [Full Text] [PDF]

				Z. Ahmed, D. Gveric, G. Pryce, D. Baker, J. P. Leonard, and M. L. Cuzner Myelin/Axonal Pathology in Interleukin-12 Induced Serial Relapses of Experimental Allergic Encephalomyelitis in the Lewis Rat Am. J. Pathol., June 1, 2001; 158(6): 2127 - 2138. [Abstract] [Full Text] [PDF]

				R. Di Marco, G. Puglisi, G. Papaccio, A. Nicoletti, F. Patti, A. Reggio, K. Bendtzen, and F. Nicoletti Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat Multiple Sclerosis, April 1, 2001; 7(2): 101 - 104. [Abstract] [PDF]

				C. S. Constantinescu, M. Wysocka, B. Hilliard, E. S. Ventura, E. Lavi, G. Trinchieri, and A. Rostami Antibodies Against IL-12 Prevent Superantigen-Induced and Spontaneous Relapses of Experimental Autoimmune Encephalomyelitis J. Immunol., November 1, 1998; 161(9): 5097 - 5104. [Abstract] [Full Text] [PDF]