This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dogan, A. Articles by Isaacson, P. G. Search for Related Content PubMed PubMed Citation Articles by Dogan, A. Articles by Isaacson, P. G.

American Journal of Pathology, Vol 151, 1361-1369, Copyright © 1997 by American Society for Investigative Pathology

REGULAR ARTICLES

Expression of lymphocyte homing receptors and vascular addressins in low-grade gastric B-cell lymphomas of mucosa-associated lymphoid tissue

A Dogan, M Du, A Koulis, MJ Briskin and PG Isaacson
Department of Histopathology, University College London Medical School, United Kingdom. a.dogan@ucl.ac.uk

In this study, we examined lymphocyte homing receptor and vascular addressin expression in a case of primary gastric B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) with a secondary intestinal spread. We compared the findings with that observed in B cells of normal MALT and MALT acquired as a consequence of Helicobacter pylori- associated gastritis and other low-grade gastric B-cell MALT lymphomas. The neoplastic B cells in the gastric tumor were alpha 4 beta 7-, CD62L+, whereas the intestinal secondary was alpha 4 beta 7+, CD62L-. Incubation of isolated tumor cells from the stomach by H. pylori generated T-cell-dependent proliferation of neoplastic B cells and induced expression of alpha 4 beta 7 integrin similar to the intestinal tumor. These observations indicate that reversal of homing receptor profile in the gastric tumor by antigen specific stimulation may be responsible for secondary intestinal dissemination. In normal stomach and normal MALT, alpha 4 beta 7 and CD62L expression reflected the differentiation of the B cell. Plasma cells were alpha 4 beta 7+, CD62L- , whereas a subset of memory B cells were alpha 4 beta 7-, CD62L+. Homing receptor expression in MALT lymphoma B cells was heterogeneous, however, in line with their memory B-cell phenotype in the majority of cases, the neoplastic B cells were alpha 4 beta 7-, CD62L+. Neoplastic plasma cells were always alpha 4 beta 7+, CD62L-. The venules in normal gastric mucosa expressed mucosal addressin cell adhesion molecule-1 but not peripheral lymph node addressin. In normal MALT, H. pylori- associated follicular gastritis and MALT lymphomas high endothelial venules coexpressed mucosal addressin cell adhesion molecule-1 and peripheral lymph node addressin. These findings suggest expression of lymphocyte homing receptors by B cells and vascular addressins by mucosal venules are similar in normal MALT and MALT lymphomas, and factors controlling normal mucosal B-cell traffic are also operational in MALT lymphomas.

This article has been cited by other articles:

				J. P. de Boer, R. F. Hiddink, M. Raderer, N. Antonini, B. M. P. Aleman, H. Boot, and D. de Jong Dissemination patterns in non-gastric MALT lymphoma Haematologica, February 1, 2008; 93(2): 201 - 206. [Abstract] [Full Text] [PDF]

				A. J. A. Deutsch, A. Aigelsreiter, P. B. Staber, A. Beham, W. Linkesch, C. Guelly, R. I. Brezinschek, M. Fruhwirth, W. Emberger, M. Buettner, et al. MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation Blood, April 15, 2007; 109(8): 3500 - 3504. [Abstract] [Full Text] [PDF]

				B. Streubel, D. Huber, S. Wohrer, A. Chott, and M. Raderer Reverse Transcription-PCR for t(11;18)(q21;q21) Staging and Monitoring in Mucosa-Associated Lymphoid Tissue Lymphoma. Clin. Cancer Res., October 15, 2006; 12(20): 6023 - 6028. [Abstract] [Full Text] [PDF]

				M-Q Du and J C Atherton Molecular subtyping of gastric MALT lymphomas: implications for prognosis and management. Gut, June 1, 2006; 55(6): 886 - 893. [Full Text] [PDF]

				A. Lundgren, C. Trollmo, A. Edebo, A.-M. Svennerholm, and B. S. Lundin Helicobacter pylori-Specific CD4+ T Cells Home to and Accumulate in the Human Helicobacter pylori-Infected Gastric Mucosa Infect. Immun., September 1, 2005; 73(9): 5612 - 5619. [Abstract] [Full Text] [PDF]

				M. Raderer, B. Streubel, S. Woehrer, A. Puespoek, U. Jaeger, M. Formanek, and A. Chott High Relapse Rate in Patients with MALT Lymphoma Warrants Lifelong Follow-up Clin. Cancer Res., May 1, 2005; 11(9): 3349 - 3352. [Abstract] [Full Text] [PDF]

				M. Kobayashi, J. Mitoma, N. Nakamura, T. Katsuyama, J. Nakayama, and M. Fukuda Induction of peripheral lymph node addressin in human gastric mucosa infected by Helicobacter pylori PNAS, December 21, 2004; 101(51): 17807 - 17812. [Abstract] [Full Text] [PDF]

				S. de Sanjose, A. Dickie, T. Alvaro, V. Romagosa, M. Garcia Villanueva, E. Domingo-Domenech, A. Fernandez de Sevilla, and E. El-Omar Helicobacter pylori and Malignant Lymphoma in Spain Cancer Epidemiol. Biomarkers Prev., June 1, 2004; 13(6): 944 - 948. [Abstract] [Full Text] [PDF]

				R. Yamasaki, K. Yokota, H. Okada, S. Hayashi, M. Mizuno, T. Yoshino, Y. Hirai, D. Saitou, T. Akagi, and K. Oguma Immune response in Helicobacter pylori-induced low-grade gastric-mucosa-associated lymphoid tissue (MALT) lymphoma J. Med. Microbiol., January 1, 2004; 53(1): 21 - 29. [Abstract] [Full Text] [PDF]

				N. H. Shomer, J. G. Fox, A. E. Juedes, and N. H. Ruddle Helicobacter-Induced Chronic Active Lymphoid Aggregates Have Characteristics of Tertiary Lymphoid Tissue Infect. Immun., June 1, 2003; 71(6): 3572 - 3577. [Abstract] [Full Text] [PDF]

				E. Zucca, A. Conconi, E. Pedrinis, S. Cortelazzo, T. Motta, M. K. Gospodarowicz, B. J. Patterson, A. J. M. Ferreri, M. Ponzoni, L. Devizzi, et al. Nongastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue Blood, April 1, 2003; 101(7): 2489 - 2495. [Abstract] [Full Text] [PDF]

				M Quiding-Jarbrink, H Lonroth, I Ahlstedt, J Holmgren, and A-M Svennerholm Human gastric B cell responses can be induced by intestinal immunisation Gut, October 1, 2001; 49(4): 512 - 518. [Abstract] [Full Text] [PDF]

				M Quiding-Jarbrink, I Ahlstedt, C Lindholm, E-L Johansson, and H Lonroth Homing commitment of lymphocytes activated in the human gastric and intestinal mucosa Gut, October 1, 2001; 49(4): 519 - 525. [Abstract] [Full Text] [PDF]

				F. Cavalli, P. G. Isaacson, R. D. Gascoyne, and E. Zucca MALT Lymphomas Hematology, January 1, 2001; 2001(1): 241 - 258. [Abstract] [Full Text] [PDF]

				G. Rossi, D. Fortuna, L. Pancotto, G. Renzoni, E. Taccini, P. Ghiara, R. Rappuoli, and G. Del Giudice Immunohistochemical Study of Lymphocyte Populations Infiltrating the Gastric Mucosa of Beagle Dogs Experimentally Infected with Helicobacter pylori Infect. Immun., August 1, 2000; 68(8): 4769 - 4772. [Abstract] [Full Text] [PDF]

				A W Bates, A J Norton, and S I Baithun Malignant lymphoma of the urinary bladder: a clinicopathological study of 11 cases J. Clin. Pathol., June 1, 2000; 53(6): 458 - 461. [Abstract] [Full Text] [PDF]

				P. Drillenburg and S. T. Pals Cell adhesion receptors in lymphoma dissemination Blood, March 15, 2000; 95(6): 1900 - 1910. [Abstract] [Full Text] [PDF]

				C. Thieblemont, F. Berger, C. Dumontet, I. Moullet, F. Bouafia, P. Felman, G. Salles, and B. Coiffier Mucosa-associated lymphoid tissue lymphoma is a disseminated disease in one third of 158 patients analyzed Blood, February 1, 2000; 95(3): 802 - 806. [Abstract] [Full Text] [PDF]

				K. L. Csencsits, M. A. Jutila, and D. W. Pascual Nasal-Associated Lymphoid Tissue: Phenotypic and Functional Evidence for the Primary Role of Peripheral Node Addressin in Naive Lymphocyte Adhesion to High Endothelial Venules in a Mucosal Site J. Immunol., August 1, 1999; 163(3): 1382 - 1389. [Abstract] [Full Text] [PDF]