| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 151, 1577-1585, Copyright © 1997 by American Society for Investigative Pathology
REGULAR ARTICLES |
I Raymond, T Al Saati, J Tkaczuk, S Chittal and G Delsol
Department of Pathology and CIGH/CNRS, CHU Purpan, Toulouse, France.
A new monoclonal antibody (MAb), CNA.42, was generated using the CEM T- cell line. It recognizes a 120-kd formalin-resistant glycosylated antigen that is mainly expressed by follicular dendritic reticulum cells (FDRCs). This antigen is also expressed by a few mononuclear cells in the paracortical area of reactive lymph nodes and by some cortical thymocytes. Two hundred and eighty-nine cases of hematopoietic tumors of various types were tested with this antibody. They showed either intact FDRC networks or FDRC networks dispersed among malignant cells. In follicular lymphomas, the follicular pattern was highlighted by CNA.42 MAb. Expanded FDRC networks were found in angioimmunoblastic T-cell lymphomas. Neoplastic cells were positive in 43.6% (24/55) of T- cell and 4.6% (6/129) of B-cell lymphomas. The highest percentage of cases with positive neoplastic cells was found in anaplastic large-cell lymphomas (62.5%; 15/24). In Hodgkin's disease, FDRC networks, sometimes encasing Hodgkin and Reed-Sternberg (HRS) cells, were found. HRS cells were also stained by this antibody in 23 (21.9%) of the 105 cases examined. A variety of normal nonlymphoid tissues and nonhematopoietic tumors, such as some neurogenic tumors, carcinoma, and occasional sarcomas, were found to be positive. Analysis of the reactivity of CNA.42 antibody with FDRCs of lymphoid tissue from different animal species showed similar reactivity to that observed in humans, suggesting widespread evolutionary conservation of the antigen recognized by this antibody. In daily diagnostic practice, CNA.42 MAb seems to be a suitable FDRC marker and possibly has an auxiliary role in recognizing T-cell lymphomas.
This article has been cited by other articles:
 |
|
 |
|
  Y. Usui, J. Parikh, H. Goto, and N. A Rao Immunopathology of necrotising scleritis Br. J. Ophthalmol., March 1, 2008; 92(3): 417 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Lefevre, W. R. Hein, Z. Stamataki, L. S. Brackenbury, E. A. Supple, L. G. Hunt, P. Monaghan, G. Borhis, Y. Richard, and B. Charleston Fibrinogen is localized on dark zone follicular dendritic cells in vivo and enhances the proliferation and survival of a centroblastic cell line in vitro J. Leukoc. Biol., September 1, 2007; 82(3): 666 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Austbo, A. Espenes, I. Olsaker, C. McL. Press, and G. Skretting Lymphoid follicles of the ileal Peyer's patch of lambs express low levels of PrP, as demonstrated by quantitative real-time RT-PCR on microdissected tissue compartments, in situ hybridization and immunohistochemistry. J. Gen. Virol., November 1, 2006; 87(Pt 11): 3463 - 3471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Genton, Y. Wang, S. Izui, B. Malissen, G. Delsol, G. J. Fournie, M. Malissen, and H. Acha-Orbea The Th2 Lymphoproliferation Developing in LatY136F Mutant Mice Triggers Polyclonal B Cell Activation and Systemic Autoimmunity J. Immunol., August 15, 2006; 177(4): 2285 - 2293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Y. Lee, E.-M. Ko, S.-H. Kim, D.-I. Jeoung, and J. Choe Human Follicular Dendritic Cells Express Prostacyclin Synthase: A Novel Mechanism to Control T Cell Numbers in the Germinal Center J. Immunol., August 1, 2005; 175(3): 1658 - 1664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P A Caplazi, K I O'Rourke, and T V Baszler Resistance to scrapie in PrP ARR/ARQ heterozygous sheep is not caused by preferential allelic use J. Clin. Pathol., June 1, 2004; 57(6): 647 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Maeda, M. Matsuda, H. Suzuki, and H.-a. Saitoh Immunohistochemical Recognition of Human Follicular Dendritic Cells (FDCs) in Routinely Processed Paraffin Sections J. Histochem. Cytochem., November 1, 2002; 50(11): 1475 - 1486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Andreoletti, P. Berthon, E. Levavasseur, D. Marc, F. Lantier, E. Monks, J.-M. Elsen, and F. Schelcher Phenotyping of Protein-Prion (PrPsc)-accumulating Cells in Lymphoid and Neural Tissues of Naturally Scrapie-affected Sheep by Double-labeling Immunohistochemistry J. Histochem. Cytochem., October 1, 2002; 50(10): 1357 - 1370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Sigurdson, C. Barillas-Mury, M. W. Miller, B. Oesch, L. J. M. van Keulen, J. P. M. Langeveld, and E. A. Hoover PrPCWD lymphoid cell targets in early and advanced chronic wasting disease of mule deer J. Gen. Virol., October 1, 2002; 83(10): 2617 - 2628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V Uhlmann, C M Martin, O Sheils, L Pilkington, I Silva, A Killalea, S B Murch, J Walker-Smith, M Thomson, A J Wakefield, et al. Potential viral pathogenic mechanism for new variant inflammatory bowel disease Mol. Pathol., April 1, 2002; 55(2): 84 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kojima, S. Nakamura, K. Ichimura, K. Shimizu, H. Itoh, and N. Masawa Follicular Lymphoma of the Salivary Gland: A Clinicopathological and Molecular Study of Six Cases International Journal of Surgical Pathology, October 1, 2001; 9(4): 287 - 293. [Abstract] [PDF]
|
|
|
|
|
|
M. Kojima, S. Nakamura, K. Shimizu, Y. Hosomura, Y. Ohno, H. Itoh, N. Yamane, K. Yoshida, and N. Masawa Inflammatory Pseudotumor of Lymph Nodes: Clinicopathologic and Immunohistological Study of 11 Japanese Cases International Journal of Surgical Pathology, July 1, 2001; 9(3): 207 - 214. [Abstract] [PDF]
|
|
|
|
|
|
O. Andréoletti, P. Berthon, D. Marc, P. Sarradin, J. Grosclaude, L. van Keulen, F. Schelcher, J.-M. Elsen, and F. Lantier Early accumulation of PrPSc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie J. Gen. Virol., December 1, 2000; 81(12): 3115 - 3126. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
