help button home button Am J Pathol Epitomics Buy 2 Antibodies Get 1 Free Special Offer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lindner, G.
Right arrow Articles by Paus, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lindner, G.
Right arrow Articles by Paus, R.

American Journal of Pathology, Vol 151, 1601-1617, Copyright © 1997 by American Society for Investigative Pathology

REGULAR ARTICLES

Analysis of apoptosis during hair follicle regression (catagen)

G Lindner, VA Botchkarev, NV Botchkareva, G Ling, C van der Veen and R Paus
Department of Dermatology, Charite, Humboldt-Universitat zu Berlin, Germany.

Keratinocyte apoptosis is a central element in the regulation of hair follicle regression (catagen), yet the exact location and the control of follicular keratinocyte apoptosis remain obscure. To generate an "apoptomap" of the hair follicle, we have studied selected apoptosis- associated parameters in the C57BL/6 mouse model for hair research during normal and pharmacologically manipulated, pathological catagen development. As assessed by terminal deoxynucleotide transferase dUTP fluorescein nick end-labeling (TUNEL) stain, apoptotic cells not only appeared in the regressing proximal follicle epithelium but, surprisingly, were also seen in the central inner root sheath, in the bulge/isthmus region, and in the secondary germ, but never in the dermal papilla. These apoptosis hot spots during catagen development correlated largely with a down-regulation of the Bcl-2/Bax ratio but only poorly with the expression patterns of interleukin-1beta converting enzyme, p55TNFR, and Fas/Apo-1 immunoreactivity. Instead, a higher correlation was found with p75NTR expression. During cyclophosphamide-induced follicle dystrophy and alopecia, massive keratinocyte apoptosis occurred in the entire proximal hair bulb, except in the dermal papilla, despite a strong up-regulation of Bax and p75NTR immunoreactivity. Selected receptors of the tumor necrosis factor/nerve growth factor family and members of the Bcl-2 family may also play a key role in the control of follicular keratinocyte apoptosis in situ.


This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
B. D. Yu, A. Mukhopadhyay, and C. Wong
Skin and hair: models for exploring organ regeneration
Hum. Mol. Genet., April 15, 2008; 17(R1): R54 - R59.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
E. Bodo, A. Kromminga, W. Funk, M. Laugsch, U. Duske, W. Jelkmann, and R. Paus
Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin
FASEB J, October 1, 2007; 21(12): 3346 - 3354.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. Bodo, D. J. Tobin, Y. Kamenisch, T. Biro, M. Berneburg, W. Funk, and R. Paus
Dissecting the Impact of Chemotherapy on the Human Hair Follicle: A Pragmatic in Vitro Assay for Studying the Pathogenesis and Potential Management of Hair Follicle Dystrophy
Am. J. Pathol., October 1, 2007; 171(4): 1153 - 1167.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Lee, J. M. Basak, S. Demehri, and R. Kopan
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes
Development, August 1, 2007; 134(15): 2795 - 2806.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
M. Tsai-Turton, B. T. Luong, Y. Tan, and U. Luderer
Cyclophosphamide-Induced Apoptosis in COV434 Human Granulosa Cells Involves Oxidative Stress and Glutathione Depletion
Toxicol. Sci., July 1, 2007; 98(1): 216 - 230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Y. Fessing, T. Y. Sharova, A. A. Sharov, R. Atoyan, and V. A. Botchkarev
Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)
Am. J. Pathol., December 1, 2006; 169(6): 2075 - 2084.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
U. Ohnemus, M. Uenalan, J. Inzunza, J.-A. Gustafsson, and R. Paus
The Hair Follicle as an Estrogen Target and Source
Endocr. Rev., October 1, 2006; 27(6): 677 - 706.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
P. C. Arck, R. Overall, K. Spatz, C. Liezman, B. Handjiski, B. F. Klapp, M. A. Birch-Machin, and E. M. J. Peters
Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage
FASEB J, July 1, 2006; 20(9): 1567 - 1569.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. Okada, Y. Ishii, K. Masujin, A. Yasoshima, J. Matsuda, A. Ogura, H. Nakayama, T. Kunieda, and K. Doi
The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in the Hair Follicle Morphogenesis and Homeostasis: The Allelic Difference Provides Novel Insights into Hair Follicle Biology
Am. J. Pathol., April 1, 2006; 168(4): 1119 - 1133.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
E. M.J. Peters, S. Hendrix, G. Golz, B. F. Klapp, P. C. Arck, and R. Paus
Nerve Growth Factor and its Precursor Differentially Regulate Hair Cycle Progression in Mice
J. Histochem. Cytochem., March 1, 2006; 54(3): 275 - 288.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
L. Alonso and E. Fuchs
The hair cycle
J. Cell Sci., February 1, 2006; 119(3): 391 - 393.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. M.J. Peters, M. G. Stieglitz, C. Liezman, R. W. Overall, M. Nakamura, E. Hagen, B. F. Klapp, P. Arck, and R. Paus
p75 Neurotrophin Receptor-Mediated Signaling Promotes Human Hair Follicle Regression (Catagen)
Am. J. Pathol., January 1, 2006; 168(1): 221 - 234.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Yang, C. Mao, Y. Teng, W. Li, J. Zhang, X. Cheng, X. Li, X. Han, Z. Xia, H. Deng, et al.
Targeted Disruption of Smad4 in Mouse Epidermis Results in Failure of Hair Follicle Cycling and Formation of Skin Tumors
Cancer Res., October 1, 2005; 65(19): 8671 - 8678.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
R. Mazzieri, V. Jurukovski, H. Obata, J. Sung, A. Platt, E. Annes, N. Karaman-Jurukovska, P.-E. Gleizes, and D. B. Rifkin
Expression of truncated latent TGF-{beta}-binding protein modulates TGF-{beta} signaling
J. Cell Sci., May 15, 2005; 118(10): 2177 - 2187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. Bodo, T. Biro, A. Telek, G. Czifra, Z. Griger, B. I. Toth, A. Mescalchin, T. Ito, A. Bettermann, L. Kovacs, et al.
A Hot New Twist to Hair Biology: Involvement of Vanilloid Receptor-1 (VR1/TRPV1) Signaling in Human Hair Growth Control
Am. J. Pathol., April 1, 2005; 166(4): 985 - 998.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
U. Ohnemus, M. Uenalan, F. Conrad, B. Handjiski, L. Mecklenburg, M. Nakamura, J. Inzunza, J.-A. Gustafsson, and R. Paus
Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor (ER)-{alpha} Is Checked by ER{beta} Signaling
Endocrinology, March 1, 2005; 146(3): 1214 - 1225.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Slominski, D. J. Tobin, S. Shibahara, and J. Wortsman
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
Physiol Rev, October 1, 2004; 84(4): 1155 - 1228.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. A. Sharov, F. Siebenhaar, T. Y. Sharova, N. V. Botchkareva, B. A. Gilchrest, and V. A. Botchkarev
Fas Signaling Is Involved in the Control of Hair Follicle Response to Chemotherapy
Cancer Res., September 1, 2004; 64(17): 6266 - 6270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
U. Guha, L. Mecklenburg, P. Cowin, L. Kan, W. M. O'Guin, D. D'Vizio, R. G. Pestell, R. Paus, and J. A. Kessler
Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling
Am. J. Pathol., September 1, 2004; 165(3): 729 - 740.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. M. J. Peters, B. Handjiski, A. Kuhlmei, E. Hagen, H. Bielas, A. Braun, B. F. Klapp, R. Paus, and P. C. Arck
Neurogenic Inflammation in Stress-Induced Termination of Murine Hair Growth Is Promoted by Nerve Growth Factor
Am. J. Pathol., July 1, 2004; 165(1): 259 - 271.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Andl, K. Ahn, A. Kairo, E. Y. Chu, L. Wine-Lee, S. T. Reddy, N. J. Croft, J. A. Cebra-Thomas, D. Metzger, P. Chambon, et al.
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development
Development, May 15, 2004; 131(10): 2257 - 2268.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. Ito, N. Ito, A. Bettermann, Y. Tokura, M. Takigawa, and R. Paus
Collapse and Restoration of MHC Class-I-Dependent Immune Privilege: Exploiting the Human Hair Follicle as a Model
Am. J. Pathol., February 1, 2004; 164(2): 623 - 634.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
S. Sofroniadou, C. Kosmas, T. Kourelis, T. Makatsoris, A. Koutras, A. Onienadoum, and H. P. Kalofonos
Absence of chemotherapy-induced alopecia with paclitaxel in a case of hypothyroidism: case report
Ann. Onc., November 1, 2003; 14(11): 1690 - 1691.
[Full Text] [PDF]

Home page
 J. Cell Sci.Home page
F. J. A. Conti, R. J. Rudling, A. Robson, and K. M. Hodivala-Dilke
{alpha}3{beta}1-integrin regulates hair follicle but not interfollicular morphogenesis in adult epidermis
J. Cell Sci., July 1, 2003; 116(13): 2737 - 2747.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. Gafter-Gvili, B. Sredni, R. Gal, U. Gafter, and Y. Kalechman
Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes
Am J Physiol Cell Physiol, June 1, 2003; 284(6): C1593 - C1603.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Foitzik, K. Krause, A. J. Nixon, C. A. Ford, U. Ohnemus, A. J. Pearson, and R. Paus
Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen
Am. J. Pathol., May 1, 2003; 162(5): 1611 - 1621.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. Ma, J. Liu, T. Wu, M. Plikus, T.-X. Jiang, Q. Bi, Y.-H. Liu, S. Muller-Rover, H. Peters, J. P. Sundberg, et al.
`Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation
Development, March 2, 2003; 130(2): 379 - 389.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
P. C. Arck, B. Handjiski, E. M. J. Peters, A. S. Peter, E. Hagen, A. Fischer, B. F. Klapp, and R. Paus
Stress Inhibits Hair Growth in Mice by Induction of Premature Catagen Development and Deleterious Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways
Am. J. Pathol., March 1, 2003; 162(3): 803 - 814.
[Abstract] [Full Text] [PDF]

Home page
 Annals of Clinical & Laboratory ScienceHome page
M. B. Morgan and P. Rose
An Investigation of Apoptosis in Androgenetic Alopecia
Ann. Clin. Lab. Sci., January 1, 2003; 33(1): 107 - 112.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
F. Benavides, M. F. Starost, M. Flores, I. B. Gimenez-Conti, J.-L. Guenet, and C. J. Conti
Impaired Hair Follicle Morphogenesis and Cycling with Abnormal Epidermal Differentiation in nackt Mice, a Cathepsin L-Deficient Mutation
Am. J. Pathol., August 1, 2002; 161(2): 693 - 703.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. J. Tobin, K. Foitzik, T. Reinheckel, L. Mecklenburg, V. A. Botchkarev, C. Peters, and R. Paus
The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling
Am. J. Pathol., May 1, 2002; 160(5): 1807 - 1821.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Liu, V. Alexander, K. Vijayachandra, E. Bhogte, I. Diamond, and A. Glick
Conditional epidermal expression of TGFbeta 1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia
PNAS, July 31, 2001; 98(16): 9139 - 9144.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
V. A. Botchkarev, E. A. Komarova, F. Siebenhaar, N. V. Botchkareva, A. A. Sharov, P. G. Komarov, M. Maurer, A. V. Gudkov, and B. A. Gilchrest
p53 Involvement in the Control of Murine Hair Follicle Regression
Am. J. Pathol., June 1, 2001; 158(6): 1913 - 1919.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
N. V. BOTCHKAREVA, M. KHLGATIAN, B. J. LONGLEY, V. A. BOTCHKAREV, and B. A. GILCHREST
SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit
FASEB J, March 1, 2001; 15(3): 645 - 658.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. A. Panteleyev, C. A. B. Jahoda, and A. M. Christiano
Hair follicle predetermination
J. Cell Sci., January 10, 2001; 114(19): 3419 - 3431.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
K. S. Stenn and R. Paus
Controls of Hair Follicle Cycling
Physiol Rev, January 1, 2001; 81(1): 449 - 494.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
S. Jackson, C. Harwood, M. Thomas, L. Banks, and A. Storey
Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins
Genes & Dev., December 1, 2000; 14(23): 3065 - 3073.
[Abstract] [Full Text]

Home page
 FASEB J.Home page
V. A. BOTCHKAREV, N. V. BOTCHKAREVA, K. M. ALBERS, L.-H. CHEN, P. WELKER, and R. PAUS
A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression
FASEB J, October 1, 2000; 14(13): 1931 - 1942.
[Abstract] [Full Text]

Home page
 FASEB J.Home page
W. ROTH, J. DEUSSING, V. A. BOTCHKAREV, M. PAULY-EVERS, P. SAFTIG, A. HAFNER, P. SCHMIDT, W. SCHMAHL, J. SCHERER, I. ANTON-LAMPRECHT, et al.
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling
FASEB J, October 1, 2000; 14(13): 2075 - 2086.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
V. A. Botchkarev, E. A. Komarova, F. Siebenhaar, N. V. Botchkareva, P. G. Komarov, M. Maurer, B. A. Gilchrest, and A. V. Gudkov
p53 Is Essential for Chemotherapy-induced Hair Loss
Cancer Res., September 1, 2000; 60(18): 5002 - 5006.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
D. Deplewski and R. L. Rosenfield
Role of Hormones in Pilosebaceous Unit Development
Endocr. Rev., August 1, 2000; 21(4): 363 - 392.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
E. Charpentier, R. M. Lavker, E. Acquista, and P. Cowin
Plakoglobin Suppresses Epithelial Proliferation and Hair Growth In Vivo
J. Cell Biol., April 17, 2000; 149(2): 503 - 520.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
S. Müller–Röver, S. Bulfone–Paus, B. Handjiski, P. Welker, J. P. Sundberg, I. A. McKay, V. A. Botchkarev, and R. Paus
Intercellular Adhesion Molecule-1 and Hair Follicle Regression
J. Histochem. Cytochem., April 1, 2000; 48(4): 557 - 568.
[Abstract] [Full Text]

Home page
 FASEB J.Home page
K. FOITZIK, G. LINDNER, S. MUELLER-ROEVER, M. MAURER, N. BOTCHKAREVA, V. BOTCHKAREV, B. HANDJISKI, M. METZ, T. HIBINO, T. SOMA, et al.
Control of murine hair follicle regression (catagen) by TGF-{beta}1 in vivo
FASEB J, April 1, 2000; 14(5): 752 - 760.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
S. Muller-Rover, H. Rossiter, R. Paus, B. Handjiski, E. M. J. Peters, J.-E. Murphy, L. Mecklenburg, and T. S. Kupper
Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia
Am. J. Pathol., April 1, 2000; 156(4): 1395 - 1405.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
N. V. Botchkareva, V. A. Botchkarev, P. Welker, M. Airaksinen, W. Roth, P. Suvanto, S. Muller-Rover, I. M. Hadshiew, C. Peters, and R. Paus
New Roles for Glial Cell Line-Derived Neurotrophic Factor and Neurturin : Involvement in Hair Cycle Control
Am. J. Pathol., March 1, 2000; 156(3): 1041 - 1053.
[Abstract] [Full Text] [PDF]

Home page
 Cell Growth Differ.Home page
K. Breuhahn, A. Mann, G. Müller, A. Wilhelmi, P. Schirmacher, A. Enk, and M. Blessing
Epidermal Overexpression of Granulocyte-Macrophage Colony-Stimulating Factor Induces Both Keratinocyte Proliferation and Apoptosis
Cell Growth Differ., February 1, 2000; 11(2): 111 - 121.
[Abstract] [Full Text]

Home page
 FASEB J.Home page
G. LINDNER, A. MENRAD, E. GHERARDI, G. MERLINO, P. WELKER, B. HANDJISKI, B. ROLOFF, and R. PAUS
Involvement of hepatocyte growth factor/scatter factor and Met receptor signaling in hair follicle morphogenesis and cycling
FASEB J, February 1, 2000; 14(2): 319 - 332.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
A. Le Moine, M. Surquin, F. X. Demoor, J. C. Noel, M.-A. Nahori, M. Pretolani, V. Flamand, M. Y. Braun, M. Goldman, and D. Abramowicz
IL-5 Mediates Eosinophilic Rejection of MHC Class II-Disparate Skin Allografts in Mice
J. Immunol., October 1, 1999; 163(7): 3778 - 3784.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. Song and P. F. Lambert
Different Responses of Epidermal and Hair Follicular Cells to Radiation Correlate with Distinct Patterns of p53 and p21 Induction
Am. J. Pathol., October 1, 1999; 155(4): 1121 - 1127.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Lommatzsch, A. Braun, A. Mannsfeldt, V. A. Botchkarev, N. V. Botchkareva, R. Paus, A. Fischer, G. R. Lewin, and H. Renz
Abundant Production of Brain-Derived Neurotrophic Factor by Adult Visceral Epithelia : Implications for Paracrine and Target-Derived NeurotrophicFunctions
Am. J. Pathol., October 1, 1999; 155(4): 1183 - 1193.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
R. Paus and G. Cotsarelis
The Biology of Hair Follicles
N. Engl. J. Med., August 12, 1999; 341(7): 491 - 497.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. A. Panteleyev, N. V. Botchkareva, J. P. Sundberg, A. M. Christiano, and R. Paus
The Role of the Hairless (hr) Gene in the Regulation of Hair Follicle Catagen Transformation
Am. J. Pathol., July 1, 1999; 155(1): 159 - 171.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. P. Seery, E. C. Y. Wang, V. Cattell, J. M. Carroll, M. J. Owen, and F. M. Watt
A Central Role for {alpha}{beta} T Cells in the Pathogenesis of Murine Lupus
J. Immunol., June 15, 1999; 162(12): 7241 - 7248.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
V. A. BOTCHKAREV, N. V. BOTCHKAREVA, P. WELKER, M. METZ, G. R. LEWIN, A. SUBRAMANIAM, S. BULFONE-PAUS, E. HAGEN, A. BRAUN, M. LOMMATZSCH, et al.
A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control
FASEB J, February 1, 1999; 13(2): 395 - 410.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
V. A. Botchkarev, P. Welker, K. M. Albers, N. V. Botchkareva, M. Metz, G. R. Lewin, S. Bulfone-Paus, E. M. J. Peters, G. Lindner, and R. Paus
A New Role for Neurotrophin-3 : Involvement in the Regulation of Hair Follicle Regression(Catagen)
Am. J. Pathol., September 1, 1998; 153(3): 785 - 799.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the American Society for Investigative Pathology.