This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zeimer, H. J. Articles by Grill, V. Search for Related Content PubMed PubMed Citation Articles by Zeimer, H. J. Articles by Grill, V.

American Journal of Pathology, Vol 152, 17-21, Copyright © 1998 by American Society for Investigative Pathology

REGULAR ARTICLES

Parathyroid-hormone-related protein in sarcoidosis

HJ Zeimer, TM Greenaway, J Slavin, DK Hards, H Zhou, JC Doery, AN Hunter, A Duffield, TJ Martin and V Grill
St. Vincent's Hospital, Fitzroy, Australia.

Parathyroid-hormone-related protein (PTHrP) is the main mediator of the humoral hypercalcemia of malignancy. It is also detected in many normal adult and fetal tissues. Altered calcium metabolism occurs in sarcoidosis, and two cases of sarcoidosis with hypercalcemia and elevated plasma PTHrP are described. An archival study of 20 lymph node biopsies with the pathological diagnosis of sarcoidosis was performed. Immunohistochemistry using a polyclonal antiserum to human PTHrP and in situ hybridization using a riboprobe to human PTHrP were performed on the lymph node biopsies. Immunohistochemistry for PTHrP was also performed on the biopsies from the two cases with elevated plasma levels. Immunohistochemical analysis detected PTHrP in macrophages within granulomata in 17 of the 20 (85%) biopsies. In situ hybridization detected a positive signal for messenger RNA in the granulomata of 11 of 19 (58%) biopsies. PTHrP immunoreactivity and PTHrP gene expression are present in sarcoid granulomata. PTHrP may contribute to the hypercalcemia of sarcoidosis.

This article has been cited by other articles:

				D. E. Godler, A. N. Stein, O. Bakharevski, M. M. L. Lindsay, and P. F. J. Ryan Parathyroid hormone-related peptide expression in rat collagen-induced arthritis Rheumatology, September 1, 2005; 44(9): 1122 - 1131. [Abstract] [Full Text] [PDF]

				N. Porter, H.L. Beynon, and H.S. Randeva Endocrine and reproductive manifestations of sarcoidosis QJM, August 1, 2003; 96(8): 553 - 561. [Full Text] [PDF]

				C. A. M. Wall, E. F. Gaffney, and G. J. Mellotte Hypercalcaemia and acute interstitial nephritis associated with omeprazole therapy Nephrol. Dial. Transplant., September 1, 2000; 15(9): 1450 - 1452. [Full Text] [PDF]

				A. Woywodt, W. Schneider, U. Goebel, and F. C. Luft Hypercalcemia Due to Talc Granulomatosis Chest, April 1, 2000; 117(4): 1195 - 1196. [Abstract] [Full Text] [PDF]