This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Adida, C. Articles by Altieri, D. C. Search for Related Content PubMed PubMed Citation Articles by Adida, C. Articles by Altieri, D. C.

American Journal of Pathology, Vol 152, 43-49, Copyright © 1998 by American Society for Investigative Pathology

REGULAR ARTICLES

Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation

C Adida, PL Crotty, J McGrath, D Berrebi, J Diebold and DC Altieri
Department of Pathology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.

Inhibitors of programmed cell death (apoptosis) may regulate tissue differentiation and aberrantly promote cell survival in neoplasia. A novel apoptosis inhibitor of the IAP gene family, designated survivin, was recently found in all of the most common human cancers but not in normal, terminally differentiated adult tissues. The expression of survivin in embryonic and fetal development was investigated. Immunohistochemistry and in situ hybridization studies demonstrated strong expression of survivin in several apoptosis-regulated fetal tissues, including the stem cell layer of stratified epithelia, endocrine pancreas, and thymic medulla, with a pattern that did not overlap with that of another apoptosis inhibitor, bcl-2. A sequence- specific antibody to survivin immunoblotted a single approximately 16.5- kd survivin band in human fetal lung, liver, heart, kidney, and gastrointestinal tract. In mouse embryo, prominent and nearly ubiquitous distribution of survivin was found at embryonic day (E)11.5, whereas at E15 to -21, survivin expression was restricted to the distal bronchiolar epithelium of the lung and neural-crest-derived cells, including dorsal root ganglion neurons, hypophysis, and the choroid plexus. These data suggest that expression of survivin in embryonic and fetal development may contribute to tissue homeostasis and differentiation independently of bcl-2. Aberrations of this developmental pathway may result in prominent re-expression of survivin in neoplasia and abnormally prolonged cell viability.

This article has been cited by other articles:

				H. Hu, Y. Shikama, I. Matsuoka, and J. Kimura Terminally differentiated neutrophils predominantly express Survivin-2{alpha}, a dominant-negative isoform of Survivin J. Leukoc. Biol., February 1, 2008; 83(2): 393 - 400. [Abstract] [Full Text] [PDF]

				Y. Guo, C. Mantel, R. A. Hromas, and H. E. Broxmeyer Oct-4 Is Critical for Survival/Antiapoptosis of Murine Embryonic Stem Cells Subjected to Stress: Effects Associated with Stat3/Survivin Stem Cells, January 1, 2008; 26(1): 30 - 34. [Abstract] [Full Text] [PDF]

				Q. Jin, L. Feng, C. Behrens, B. N. Bekele, I. I. Wistuba, W.-K. Hong, and H.-Y. Lee Implication of AMP-Activated Protein Kinase and Akt-Regulated Survivin in Lung Cancer Chemopreventive Activities of Deguelin Cancer Res., December 15, 2007; 67(24): 11630 - 11639. [Abstract] [Full Text] [PDF]

				B. C. Lin, R. Sullivan, Y. Lee, S. Moran, E. Glover, and C. A. Bradfield Deletion of the Aryl Hydrocarbon Receptor-associated Protein 9 Leads to Cardiac Malformation and Embryonic Lethality J. Biol. Chem., December 7, 2007; 282(49): 35924 - 35932. [Abstract] [Full Text] [PDF]

				P. Lechler, X. Wu, W. Bernhardt, V. Campean, S. Gastiger, T. Hackenbeck, B. Klanke, A. Weidemann, C. Warnecke, K. Amann, et al. The Tumor Gene Survivin Is Highly Expressed in Adult Renal Tubular Cells: Implications for a Pathophysiological Role in the Kidney Am. J. Pathol., November 1, 2007; 171(5): 1483 - 1498. [Abstract] [Full Text] [PDF]

				G. Parmiani, V. Russo, A. Marrari, G. Cutolo, C. Casati, L. Pilla, C. Maccalli, L. Rivoltini, and C. Castelli Universal and Stemness-Related Tumor Antigens: Potential Use in Cancer Immunotherapy Clin. Cancer Res., October 1, 2007; 13(19): 5675 - 5679. [Full Text] [PDF]

				A. Troeger, M. Siepermann, G. Escherich, R. Meisel, R. Willers, S. Gudowius, T. Moritz, H.-J. Laws, H. Hanenberg, U. Goebel, et al. Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia Haematologica, August 1, 2007; 92(8): 1043 - 1050. [Abstract] [Full Text] [PDF]

				F. Morgillo, W.-Y. Kim, E. S. Kim, F. Ciardiello, W. K. Hong, and H.-Y. Lee Implication of the Insulin-like Growth Factor-IR Pathway in the Resistance of Non small Cell Lung Cancer Cells to Treatment with Gefitinib Clin. Cancer Res., May 1, 2007; 13(9): 2795 - 2803. [Abstract] [Full Text] [PDF]

				A. R. Hussain, N. A. Al-Jomah, A. K. Siraj, P. Manogaran, K. Al-Hussein, J. Abubaker, L. C. Platanias, K. S. Al-Kuraya, and S. Uddin Sanguinarine-Dependent Induction of Apoptosis in Primary Effusion Lymphoma Cells Cancer Res., April 15, 2007; 67(8): 3888 - 3897. [Abstract] [Full Text] [PDF]

				O. P. Blanc-Brude, E. Teissier, Y. Castier, G. Leseche, A.-P. Bijnens, M. Daemen, B. Staels, Z. Mallat, and A. Tedgui IAP Survivin Regulates Atherosclerotic Macrophage Survival Arterioscler. Thromb. Vasc. Biol., April 1, 2007; 27(4): 901 - 907. [Abstract] [Full Text] [PDF]

				A. E. Krambeck, H. Dong, R. H. Thompson, S. M. Kuntz, C. M. Lohse, B. C. Leibovich, M. L. Blute, T. J. Sebo, J. C. Cheville, A. S. Parker, et al. Survivin and B7-H1 Are Collaborative Predictors of Survival and Represent Potential Therapeutic Targets for Patients with Renal Cell Carcinoma Clin. Cancer Res., March 15, 2007; 13(6): 1749 - 1756. [Abstract] [Full Text] [PDF]

				A. Marconi, K. Dallaglio, R. Lotti, C. Vaschieri, F. Truzzi, F. Fantini, and C. Pincelli Survivin Identifies Keratinocyte Stem Cells and Is Downregulated by Anti-{beta}1 Integrin During Anoikis Stem Cells, January 1, 2007; 25(1): 149 - 155. [Abstract] [Full Text] [PDF]

				N. Cosgrave, A. D K Hill, and L. S Young Growth factor-dependent regulation of survivin by c-myc in human breast cancer J. Mol. Endocrinol., December 1, 2006; 37(3): 377 - 390. [Abstract] [Full Text] [PDF]

				F. Li and M. G. Brattain Role of the SurvivinGene in Pathophysiology Am. J. Pathol., July 1, 2006; 169(1): 1 - 11. [Abstract] [Full Text] [PDF]

				X.-F. Che, C.-L. Zheng, S. Owatari, M. Mutoh, T. Gotanda, H.-C. Jeung, T. Furukawa, R. Ikeda, M. Yamamoto, M. Haraguchi, et al. Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines Blood, June 15, 2006; 107(12): 4880 - 4887. [Abstract] [Full Text] [PDF]

				H. Kojima, M. Iida, Y. Yaguchi, R. Suzuki, N. Hayashi, H. Moriyama, and Y. Manome Enhancement of Cisplatin sensitivity in squamous cell carcinoma of the head and neck transfected with a survivin antisense gene. Arch Otolaryngol Head Neck Surg, June 1, 2006; 132(6): 682 - 685. [Abstract] [Full Text] [PDF]

				K. Fujino, M. Ueda, M. Takehara, H. Futakuchi, K. Kanda, Y. Yamashita, Y. Terai, and M. Ueki Transcriptional expression of survivin and its splice variants in endometriosis Mol. Hum. Reprod., June 1, 2006; 12(6): 383 - 388. [Abstract] [Full Text] [PDF]

				F. Xia and D. C. Altieri Mitosis-Independent Survivin Gene Expression In vivo and Regulation by p53. Cancer Res., April 1, 2006; 66(7): 3392 - 3395. [Abstract] [Full Text] [PDF]

				T. Gritsko, A. Williams, J. Turkson, S. Kaneko, T. Bowman, M. Huang, S. Nam, I. Eweis, N. Diaz, D. Sullivan, et al. Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells Clin. Cancer Res., January 1, 2006; 12(1): 11 - 19. [Abstract] [Full Text] [PDF]

				Y. Jiang, A. de Bruin, H. Caldas, J. Fangusaro, J. Hayes, E. M. Conway, M. L. Robinson, and R. A. Altura Essential Role for Survivin in Early Brain Development J. Neurosci., July 27, 2005; 25(30): 6962 - 6970. [Abstract] [Full Text] [PDF]

				S. Hu-Lieskovan, J. Zhang, L. Wu, H. Shimada, D. E. Schofield, and T. J. Triche EWS-FLI1 Fusion Protein Up-regulates Critical Genes in Neural Crest Development and Is Responsible for the Observed Phenotype of Ewing's Family of Tumors Cancer Res., June 1, 2005; 65(11): 4633 - 4644. [Abstract] [Full Text] [PDF]

				Y. Kumazawa, K. Kawamura, T. Sato, N. Sato, Y. Konishi, Y. Shimizu, J. Fukuda, H. Kodoma, and T. Tanaka HCG up-regulates survivin mRNA in human granulosa cells Mol. Hum. Reprod., March 1, 2005; 11(3): 161 - 166. [Abstract] [Full Text] [PDF]

				M. E. Johnson and E. W. Howerth Survivin: A Bifunctional Inhibitor of Apoptosis Protein Vet. Pathol., November 1, 2004; 41(6): 599 - 607. [Abstract] [Full Text] [PDF]

				M. Iurlaro, F. Demontis, M. Corada, L. Zanetta, C. Drake, M. Gariboldi, S. Peiro, A. Cano, P. Navarro, A. Cattelino, et al. VE-Cadherin Expression and Clustering Maintain Low Levels of Survivin in Endothelial Cells Am. J. Pathol., July 1, 2004; 165(1): 181 - 189. [Abstract] [Full Text] [PDF]

				T. Zhang, J. Z. Fields, S. M. Ehrlich, and B. M. Boman The Chemopreventive Agent Sulindac Attenuates Expression of the Antiapoptotic Protein Survivin in Colorectal Carcinoma Cells J. Pharmacol. Exp. Ther., February 1, 2004; 308(2): 434 - 437. [Abstract] [Full Text] [PDF]

				E. M. Conway, F. Zwerts, V. Van Eygen, A. DeVriese, N. Nagai, W. Luo, and D. Collen Survivin-Dependent Angiogenesis in Ischemic Brain: Molecular Mechanisms of Hypoxia-Induced Up-Regulation Am. J. Pathol., September 1, 2003; 163(3): 935 - 946. [Abstract] [Full Text] [PDF]

				Z. Song, X. Yao, and M. Wu Direct Interaction between Survivin and Smac/DIABLO Is Essential for the Anti-apoptotic Activity of Survivin during Taxol-induced Apoptosis J. Biol. Chem., June 13, 2003; 278(25): 23130 - 23140. [Abstract] [Full Text] [PDF]

				H. Ryu, J. Lee, K. Zaman, J. Kubilis, R. J. Ferrante, B. D. Ross, R. Neve, and R. R. Ratan Sp1 and Sp3 Are Oxidative Stress-Inducible, Antideath Transcription Factors in Cortical Neurons J. Neurosci., May 1, 2003; 23(9): 3597 - 3606. [Abstract] [Full Text] [PDF]

				M. Kappler, M. Kotzsch, F. Bartel, S. Fussel, C. Lautenschlager, U. Schmidt, P. Wurl, M. Bache, H. Schmidt, H. Taubert, et al. Elevated Expression Level of Survivin Protein in Soft-Tissue Sarcomas Is a Strong Independent Predictor of Survival Clin. Cancer Res., March 1, 2003; 9(3): 1098 - 1104. [Abstract] [Full Text] [PDF]

				M. Ikeguchi, T. Ueta, Y. Yamane, Y. Hirooka, and N. Kaibara Inducible Nitric Oxide Synthase and Survivin Messenger RNA Expression in Hepatocellular Carcinoma Clin. Cancer Res., October 1, 2002; 8(10): 3131 - 3136. [Abstract] [Full Text] [PDF]

				S. Fukuda, R. G. Foster, S. B. Porter, and L. M. Pelus The antiapoptosis protein survivin is associated with cell cycle entry of normal cord blood CD34+ cells and modulates cell cycle and proliferation of mouse hematopoietic progenitor cells Blood, September 18, 2002; 100(7): 2463 - 2471. [Abstract] [Full Text] [PDF]

				C. Zhang, P. Hazarika, X. Ni, D. A. Weidner, and M. Duvic Induction of Apoptosis by Bexarotene in Cutaneous T-Cell Lymphoma Cells: Relevance to Mechanism of Therapeutic Action Clin. Cancer Res., May 1, 2002; 8(5): 1234 - 1240. [Abstract] [Full Text] [PDF]

				R. Bao, D. C. Connolly, M. Murphy, J. Green, J. K. Weinstein, D. A. Pisarcik, and T. C. Hamilton Activation of Cancer-Specific Gene Expression by the Survivin Promoter J Natl Cancer Inst, April 3, 2002; 94(7): 522 - 528. [Abstract] [Full Text] [PDF]

				S. Fukuda and L. M. Pelus Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34+ cells by hematopoietic growth factors: implication of survivin expression in normal hematopoiesis Blood, October 1, 2001; 98(7): 2091 - 2100. [Abstract] [Full Text] [PDF]

				B. Z. Carter, M. Milella, D. C. Altieri, and M. Andreeff Cytokine-regulated expression of survivin in myeloid leukemia Blood, May 1, 2001; 97(9): 2784 - 2790. [Abstract] [Full Text] [PDF]

				J. C. Reed Mechanisms of Apoptosis Am. J. Pathol., November 1, 2000; 157(5): 1415 - 1430. [Abstract] [Full Text] [PDF]

				C. Adida, C. Haioun, P. Gaulard, E. Lepage, P. Morel, J. Briere, H. Dombret, F. Reyes, J. Diebold, C. Gisselbrecht, et al. Prognostic significance of survivin expression in diffuse large B-cell lymphomas Blood, September 1, 2000; 96(5): 1921 - 1925. [Abstract] [Full Text] [PDF]

				G. J. R. Zaman and E. M. Conway The elusive factor Xa receptor: failure to detect transcripts that correspond to the published sequence of EPR-1 Blood, July 1, 2000; 96(1): 145 - 148. [Abstract] [Full Text] [PDF]

				R. A. Olie, A. P. Simoes-Wust, B. Baumann, S. H. Leech, D. Fabbro, R. A. Stahel, and U. Zangemeister-Wittke A Novel Antisense Oligonucleotide Targeting Survivin Expression Induces Apoptosis and Sensitizes Lung Cancer Cells to Chemotherapy Cancer Res., June 1, 2000; 60(11): 2805 - 2809. [Abstract] [Full Text] [PDF]

				A I Sarela, R C A Macadam, S M Farmery, A F Markham, and P J Guillou Expression of the antiapoptosis gene, Survivin, predicts death from recurrent colorectal carcinoma Gut, May 1, 2000; 46(5): 645 - 650. [Abstract] [Full Text] [PDF]

				J. Rohayem, P. Diestelkoetter, B. Weigle, A. Oehmichen, M. Schmitz, J. Mehlhorn, K. Conrad, and E. P. Rieber Antibody Response to the Tumor-associated Inhibitor of Apoptosis Protein Survivin in Cancer Patients Cancer Res., April 1, 2000; 60(7): 1815 - 1817. [Abstract] [Full Text]

				E. M. Conway, S. Pollefeyt, J. Cornelissen, I. DeBaere, M. Steiner-Mosonyi, K. Ong, M. Baens, D. Collen, and A. C. Schuh Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions Blood, February 15, 2000; 95(4): 1435 - 1442. [Abstract] [Full Text] [PDF]

				K. Tanaka, S. Iwamoto, G. Gon, T. Nohara, M. Iwamoto, and N. Tanigawa Expression of survivin and Its Relationship to Loss of Apoptosis in Breast Carcinomas Clin. Cancer Res., January 1, 2000; 6(1): 127 - 134. [Abstract] [Full Text]

				C. Mahotka, M. Wenzel, E. Springer, H. E. Gabbert, and C. D. Gerharz Survivin-{{Delta}}Ex3 and Survivin-2B: Two Novel Splice Variants of the Apoptosis Inhibitor Survivin with Different Antiapoptotic Properties Cancer Res., December 1, 1999; 59(24): 6097 - 6102. [Abstract] [Full Text] [PDF]

				M. Monzo, R. Rosell, E. Felip, J. Astudillo, J. J. Sanchez, J. Maestre, C. Martin, A. Font, A. Barnadas, and A. Abad A Novel Anti-Apoptosis Gene: Re-expression of Survivin Messenger RNA as a Prognosis Marker in Non-Small-Cell Lung Cancers J. Clin. Oncol., July 1, 1999; 17(7): 2100 - 2100. [Abstract] [Full Text] [PDF]

				F. Li and D. C. Altieri The Cancer Antiapoptosis Mouse Survivin Gene: Characterization of Locus and Transcriptional Requirements of Basal and Cell Cycle-dependent Expression Cancer Res., July 1, 1999; 59(13): 3143 - 3151. [Abstract] [Full Text] [PDF]

				Q. L. Deveraux and J. C. Reed IAP family proteins---suppressors of apoptosis Genes & Dev., February 1, 1999; 13(3): 239 - 252. [Full Text]

				G. Ambrosini, C. Adida, G. Sirugo, and D. C. Altieri Induction of Apoptosis and Inhibition of Cell Proliferation by survivin Gene Targeting J. Biol. Chem., May 1, 1998; 273(18): 11177 - 11182. [Abstract] [Full Text] [PDF]

				W. H. Hoffman, S. Biade, J. T. Zilfou, J. Chen, and M. Murphy Transcriptional Repression of the Anti-apoptotic survivin Gene by Wild Type p53 J. Biol. Chem., January 25, 2002; 277(5): 3247 - 3257. [Abstract] [Full Text] [PDF]