| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 152, 359-365, Copyright © 1998 by American Society for Investigative Pathology
REGULAR ARTICLES |
A Raisanen-Sokolowski, T Glysing-Jensen, J Koglin and ME Russell
Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
To investigate the functional role of interferon (IFN)-gamma in transplant arteriosclerosis, BALB/c hearts were transplanted in immunosuppressed C57BL/6J recipients with (n = 10) or without (n = 10) targeted IFN-gamma gene deletion. In 55-day heart allografts, IFN-gamma deficiency resulted in a significant decrease in vascular thickening. The severity of intimal thickening measured as the percentage of luminal occlusion (mean +/- SEM) in all elastin stained vessels (n = 410) decreased from 37+/-5% in wild-type recipients to 18+/-5% in IFN- gamma -/- recipients (P < 0.005). In the few diseased vessels in grafts from IFN-gamma -/- recipients, the neointima was more cellular with a 90% increase in the nuclear density. This finding correlated with a 50% reduction in fibrosis estimated by alpha-smooth muscle actin cell accumulation in the neointima. The reduction in severity and altered composition of vascular thickening in grafts from IFN-gamma -/- recipients shows that IFN-gamma contributes to arteriosclerotic development following transplantation.
This article has been cited by other articles:
 |
|
 |
|
  M. L. Rose Interferon-{gamma} and Intimal Hyperplasia Circ. Res., September 14, 2007; 101(6): 542 - 544. [Full Text] [PDF]
|
|
|
|
|
|
G. Tellides and J. S. Pober Interferon-{gamma} Axis in Graft Arteriosclerosis Circ. Res., March 16, 2007; 100(5): 622 - 632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Feinberg, Z. Cao, A. K. Wara, M. A. Lebedeva, S. SenBanerjee, and M. K. Jain Kruppel-like Factor 4 Is a Mediator of Proinflammatory Signaling in Macrophages J. Biol. Chem., November 18, 2005; 280(46): 38247 - 38258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Schwarze, S. L. Houser, A. Muniappan, J. S. Allan, M. T. Menard, I. McMorrow, M. E. Maloney, and J. C. Madsen Effects of Mycophenolate Mofetil on Cardiac Allograft Survival and Cardiac Allograft Vasculopathy in Miniature Swine Ann. Thorac. Surg., November 1, 2005; 80(5): 1787 - 1793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tanaka, K. Sydow, F. Gunawan, J. Jacobi, P. S. Tsao, R. C. Robbins, and J. P. Cooke Dimethylarginine Dimethylaminohydrolase Overexpression Suppresses Graft Coronary Artery Disease Circulation, September 13, 2005; 112(11): 1549 - 1556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Harvey and D. P. Ramji Interferon-{gamma} and atherosclerosis: Pro- or anti-atherogenic? Cardiovasc Res, July 1, 2005; 67(1): 11 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wessely Interference by interferons: Janus faces in vascular proliferative diseases Cardiovasc Res, June 1, 2005; 66(3): 433 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tanaka, R. D. Terry, G. K. Mokhtari, K. Inagaki, T. Koyanagi, T. Kofidis, D. Mochly-Rosen, and R. C. Robbins Suppression of Graft Coronary Artery Disease by a Brief Treatment With a Selective {epsilon}PKC Activator and a {delta}PKC Inhibitor in Murine Cardiac Allografts Circulation, September 14, 2004; 110(11_suppl_1): II-194 - II-199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Furukawa, S. E Cole, R. V Shah, Y. Fukumoto, P. Libby, and R. N Mitchell Wild-type but not interferon-{gamma}-deficient T cells induce graft arterial disease in the absence of B cells Cardiovasc Res, August 1, 2004; 63(2): 347 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Densem, I. V. Hutchinson, N. Yonan, and N. H. Brooks Influence of IFN-{gamma} polymorphism on the development of coronary vasculopathy after cardiac transplantation Ann. Thorac. Surg., March 1, 2004; 77(3): 875 - 880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hattori, H. Shimokawa, M. Higashi, J. Hiroki, Y. Mukai, K. Kaibuchi, and A. Takeshita Long-Term Treatment With a Specific Rho-Kinase Inhibitor Suppresses Cardiac Allograft Vasculopathy in Mice Circ. Res., January 9, 2004; 94(1): 46 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Vassalli, S. Fleury, J. Li, J.-J. Goy, L. Kappenberger, and L. K. von Segesser Gene transfer of cytoprotective and immunomodulatory molecules for prevention of cardiac allograft rejection Eur. J. Cardiothorac. Surg., November 1, 2003; 24(5): 794 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Vassalli, A. Gallino, M. Weis, W. von Scheidt, L. Kappenberger, L.K. von Segesser, J.-J. Goy, and on behalf of the Working Group Microcirculation of Alloimmunity and nonimmunologic risk factors in cardiac allograft vasculopathy Eur. Heart J., July 1, 2003; 24(13): 1180 - 1188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Fischbein, J. Yun, H. Laks, Y. Irie, L. Oslund-Pinderski, M. C. Fishbein, B. Bonavida, and A. Ardehali Regulated interleukin-10 expression prevents chronic rejection of transplanted hearts J. Thorac. Cardiovasc. Surg., July 1, 2003; 126(1): 216 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Afrouzian, V. Ramassar, J. Urmson, L.-F. Zhu, and P. F. Halloran Transcription Factor IRF-1 in Kidney Transplants Mediates Resistance to Graft Necrosis during Rejection J. Am. Soc. Nephrol., May 1, 2002; 13(5): 1199 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Fischbein, J. Yun, H. Laks, Y. Irie, M. C. Fishbein, B. Bonavida, and A. Ardehali Role of CD8+ lymphocytes in chronic rejection of transplanted hearts J. Thorac. Cardiovasc. Surg., April 1, 2002; 123(4): 803 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Gerdes, G. K. Sukhova, P. Libby, R. S. Reynolds, J. L. Young, and U. Schonbeck Expression of Interleukin (IL)-18 and Functional IL-18 Receptor on Human Vascular Endothelial Cells, Smooth Muscle Cells, and Macrophages: Implications for Atherogenesis J. Exp. Med., January 22, 2002; 195(2): 245 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. F. Halloran, L. W. Miller, J. Urmson, V. Ramassar, L.-F. Zhu, N. M. Kneteman, K. Solez, and M. Afrouzian IFN-{{gamma}} Alters the Pathology of Graft Rejection: Protection from Early Necrosis J. Immunol., June 15, 2001; 166(12): 7072 - 7081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. F. Halloran, M. Afrouzian, V. Ramassar, J. Urmson, L.-F. Zhu, L. M. H. Helms, K. Solez, and N. M. Kneteman Interferon-{{gamma}} Acts Directly on Rejecting Renal Allografts to Prevent Graft Necrosis Am. J. Pathol., January 1, 2001; 158(1): 215 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Fischbein, A. Ardehali, J. Yun, S. Schoenberger, H. Laks, Y. Irie, P. Dempsey, G. Cheng, M. C. Fishbein, and B. Bonavida CD40 Signaling Replaces CD4+ Lymphocytes and Its Blocking Prevents Chronic Rejection of Heart Transplants J. Immunol., December 15, 2000; 165(12): 7316 - 7322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Koglin, T. Glysing-Jensen, S. Gadiraju, and M. E. Russell Attenuated Cardiac Allograft Vasculopathy in Mice With Targeted Deletion of the Transcription Factor STAT4 Circulation, March 7, 2000; 101(9): 1034 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. TAKEI, T. N. SIMS, J. URMSON, and P. F. HALLORAN Central Role for Interferon-{gamma} Receptor in the Regulation of Renal MHC Expression J. Am. Soc. Nephrol., February 1, 2000; 11(2): 250 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Raisanen-Sokolowski, T. Glysing-Jensen, and M. E. Russell Leukocyte-Suppressing Influences of Interleukin (IL)-10 in Cardiac Allografts : Insights from IL-10 Knockout Mice Am. J. Pathol., November 1, 1998; 153(5): 1491 - 1500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Koglin, T. Glysing-Jensen, A. Raisanen-Sokolowski, and M. E. Russell Immune Sources of Transforming Growth Factor-ß1 Reduce Transplant Arteriosclerosis : Insight Derived From a Knockout Mouse Model Circ. Res., September 21, 1998; 83(6): 652 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. Mottram, A. Raisanen-Sokolowski, T. Glysing-Jensen, A. N. Stein-Oakley, and M. E. Russell2 Cardiac Allografts from IL-4 Knockout Recipients: Assessment of Transplant Arteriosclerosis and Peripheral Tolerance J. Immunol., July 15, 1998; 161(2): 602 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J o. Koglin, T. Glysing-Jensen, J. S. Mudgett, and M. E. Russell Exacerbated Transplant Arteriosclerosis in Inducible Nitric Oxide–Deficient Mice Circulation, May 26, 1998; 97(20): 2059 - 2065. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
