help button home button Am J Pathol PCR Enhanced. PCRboost from Biomatrica
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nooijen, P. T.
Right arrow Articles by Ruiter, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nooijen, P. T.
Right arrow Articles by Ruiter, D. J.

American Journal of Pathology, Vol 152, 679-682, Copyright © 1998 by American Society for Investigative Pathology

REGULAR ARTICLES

Endothelial P-selectin expression is reduced in advanced primary melanoma and melanoma metastasis

PT Nooijen, JR Westphal, AM Eggermont, C Schalkwijk, R Max, RM de Waal and DJ Ruiter
Department of Pathology, University Hospital Nijmegen, The Netherlands.

Some malignant tumors induce a cellular immune response that results in the formation of an inflammatory infiltrate and subsequent tumor regression. The infiltrating leukocytes extravasate from the bloodstream after binding to adhesion receptors on the surface of the endothelium. One of these receptors is the P-selectin molecule (CD62P) that is constitutively present on normal capillaries. We observed that P-selectin expression is absent from the microvasculature in advanced primary melanoma and in melanoma metastasis in contrast to benign melanocytic lesions where P-selectin expression was identical to that in normal skin. We suggest that one of the mechanisms by which advanced melanoma lesions evade inflammatory regression operates via a decrease of endothelial P-selectin expression.


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
C. Weishaupt, K. N. Munoz, E. Buzney, T. S. Kupper, and R. C. Fuhlbrigge
T-Cell Distribution and Adhesion Receptor Expression in Metastatic Melanoma
Clin. Cancer Res., May 1, 2007; 13(9): 2549 - 2556.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. E. M. Dirkx, M. G. A. oude Egbrink, K. Castermans, D. W. J. van der Schaft, V. L. J. L. Thijssen, R. P. M. Dings, L. Kwee, K. H. Mayo, J. Wagstaff, J. C. A. B. ter Steege, et al.
Anti-angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte-endothelium interactions and infiltration in tumors
FASEB J, April 1, 2006; 20(6): 621 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. E. M. Dirkx, M. G. A. oude Egbrink, M. J. E. Kuijpers, S. T. van der Niet, V. V. T. Heijnen, J. C. A. B.-t. Steege, J. Wagstaff, and A. W. Griffioen
Tumor Angiogenesis Modulates Leukocyte-Vessel Wall Interactions in Vivo by Reducing Endothelial Adhesion Molecule Expression
Cancer Res., May 1, 2003; 63(9): 2322 - 2329.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Tanigawa, N. Takeshita, R. A. Craig, K. Phillips, R. N. Knibbs, A. E. Chang, and L. M. Stoolman
Tumor-Specific Responses in Lymph Nodes Draining Murine Sarcomas Are Concentrated in Cells Expressing P-Selectin Binding Sites
J. Immunol., September 15, 2001; 167(6): 3089 - 3098.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
T. M. Carlos
Leukocyte recruitment at sites of tumor: dissonant orchestration
J. Leukoc. Biol., August 1, 2001; 70(2): 171 - 184.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Society for Investigative Pathology.