| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 152, 771-779, Copyright © 1998 by American Society for Investigative Pathology
REGULAR ARTICLES |
HA Crosby, S Hubscher, L Fabris, R Joplin, S Sell, D Kelly and AJ Strain
Department of Biochemistry, University of Birmingham, Queen Elizabeth and Children's Hospital, United Kingdom.
The term oval cell describes small cells with oval nuclei that arise in the periphery of the portal tracts in rat models of hepatocarcinogenesis and injury and can differentiate into either hepatocytes or bile duct cells, ie, are bipotential. The presence of such cells in human liver is controversial. Here, immunolocalization of OV-6 and two biliary markers, cytokeratin 19 (CK-19) and human epithelial antigen 125 (HEA-125) is compared in normal adult human livers and in primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) liver sections. CK-19 and HEA-125 stained bile ducts and ductules in normal liver as well as proliferating ductular structures in diseased livers. OV-6 did not label ducts or ductules in normal liver, but in PBC and PSC stained numerous proliferating ductular and periductular cells and lobular hepatocytes. In PBC, discrete OV-6-positive cells with a mature biliary-cell-like morphology were seen integrated into some intact bile ducts as well as occasional small immature oval-like cells. In addition, in PSC, hepatocytes in regenerating lobules were also strongly stained with OV-6, and on close inspection, in both PBC and PSC, oval cells and small hepatocytes at the margins of the lobules were strongly labeled. In contrast to the rat liver, OV-6 and CK-19 staining did not always co-localize. It is proposed that the small OV-6-positive oval cells are analogous to those seen in rat models and may represent human liver progenitor cells that may differentiate into OV-6-positive ductal cells or lobular hepatocytes.
This article has been cited by other articles:
 |
|
 |
|
  T S Weiss, M Lichtenauer, S Kirchner, P Stock, H Aurich, B Christ, G Brockhoff, L A Kunz-Schughart, K-W Jauch, H-J Schlitt, et al. Hepatic progenitor cells from adult human livers for cell transplantation Gut, August 1, 2008; 57(8): 1129 - 1138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sell and H. L. Leffert Liver Cancer Stem Cells J. Clin. Oncol., June 10, 2008; 26(17): 2800 - 2805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Duret, S. Gerbal-Chaloin, J. Ramos, J.-M. Fabre, E. Jacquet, F. Navarro, P. Blanc, A. Sa-Cunha, P. Maurel, and M. Daujat-Chavanieu Isolation, Characterization, and Differentiation to Hepatocyte-Like Cells of Nonparenchymal Epithelial Cells from Adult Human Liver Stem Cells, July 1, 2007; 25(7): 1779 - 1790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Stamp, H. A. Crosby, S. M. Hawes, A. J. Strain, and M. F. Pera A Novel Cell-Surface Marker Found on Human Embryonic Hepatoblasts and a Subpopulation of Hepatic Biliary Epithelial Cells Stem Cells, January 1, 2005; 23(1): 103 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Masson, D. J. Harrison, J. N. Plevris, and P. N. Newsome Potential of Hematopoietic Stem Cell Therapy in Hepatology: A Critical Review Stem Cells, November 1, 2004; 22(6): 897 - 907. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Roskams, S. Q. Yang, A. Koteish, A. Durnez, R. DeVos, X. Huang, R. Achten, C. Verslype, and A. M. Diehl Oxidative Stress and Oval Cell Accumulation in Mice and Humans with Alcoholic and Nonalcoholic Fatty Liver Disease Am. J. Pathol., October 1, 2003; 163(4): 1301 - 1311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C. Bisgaard, U. Holmskov, E. Santoni-Rugiu, P. Nagy, O. Nielsen, P. Ott, E. Hage, K. Dalhoff, L. J. Rasmussen, and N. Tygstrup Heterogeneity of Ductular Reactions in Adult Rat and Human Liver Revealed by Novel Expression of Deleted in Malignant Brain Tumor 1 Am. J. Pathol., October 1, 2002; 161(4): 1187 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Garcia, S. E. Erdman, S. Xu, Y. Feng, A. B. Rogers, M. D. Schrenzel, J. C. Murphy, and J. G. Fox Hepatobiliary Inflammation, Neoplasia, and Argyrophilic Bacteria in a Ferret Colony Vet. Pathol., March 1, 2002; 39(2): 173 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lee, C. Tarn, W.-H. Wang, S. Chen, R. L. Hullinger, and O. M. Andrisani Hepatitis B Virus X Protein Differentially Regulates Cell Cycle Progression in X-transforming Versus Nontransforming Hepatocyte (AML12) Cell Lines J. Biol. Chem., March 1, 2002; 277(10): 8730 - 8740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A J STRAIN and H A CROSBY Hepatic stem cells Gut, June 1, 2000; 46(6): 743 - 745. [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Okihiro and D. E. Hinton Partial Hepatectomy and Bile Duct Ligation in Rainbow Trout (Oncorhynchus mykiss): Histologic, Immunohistochemical and Enzyme Histochemical Characterization of Hepatic Regeneration and Biliary Hyperplasia Toxicol Pathol, March 1, 2000; 28(2): 342 - 356. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
