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American Journal of Pathology, Vol 152, 1099-1103, Copyright © 1998 by American Society for Investigative Pathology

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A rat model of spontaneous myopathy and malignant hyperthermia

LE Gonzalez, CV Melendez-Vasquez, NA Gregson and SE File
Psychopharmacology Research Unit, United Medical and Dental Schools, Guy's Hospital, London, United Kingdom.

Malignant hyperthermia is a main cause of death during general anesthesia, particularly in children. However, research has been hampered by the lack of a convenient animal model, the only one available being a special strain of pig. In this study, we describe spontaneous myopathy and a fatal syndrome of generalized muscle rigidity triggered by halothane in an outbred strain of rat. Histological examination of skeletal muscle reveals severe abnormalities indicating chronic underlying myopathy. The association of histological abnormalities with an acute, fatal syndrome clinically resembling malignant hyperthermia provides a strong basis for a new and extremely useful animal model to study this fatal disorder.




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Copyright © 1998 by the American Society for Investigative Pathology.