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American Journal of Pathology, Vol 152, 1107-1123, Copyright © 1998 by American Society for Investigative Pathology

REVIEWS

DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies

S Knuutila, AM Bjorkqvist, K Autio, M Tarkkanen, M Wolf, O Monni, J Szymanska, ML Larramendy, J Tapper, H Pere, W El-Rifai, S Hemmer, VM Wasenius, V Vidgren and Y Zhu
Laboratory of Medical Genetics, Helsinki University Central Hospital, Finland. sakari.knuutila@helsinki.fi

This review summarizes reports of recurrent DNA sequence copy number amplifications in human neoplasms detected by comparative genomic hybridization. Some of the chromosomal areas with recurrent DNA copy number amplifications (amplicons) of 1p22-p31, 1p32-p36, 1q, 2p13-p16, 2p23-p25, 2q31-q33, 3q, 5p, 6p12-pter, 7p12-p13, 7q11.2, 7q21-q22, 8p11- p12, 8q, 11q13-q14, 12p, 12q13-q21, 13q14, 13q22-qter, 14q13-q21, 15q24- qter, 17p11.2-p12, 17q12-q21, 17q22-qter, 18q, 19p13.2-pter, 19cen- q13.3, 20p11.2-p12, 20q, Xp11.2-p21, and Xp11-q13 and genes therein are presented in more detail. The paper with more than 150 references and two tables can be accessed from our web site http://www.helsinki.fi/~lgl_www/CMG.html. The data will be updated biannually until the year 2001.


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DNA Sequence Copy Number Changes in Gastrointestinal Stromal Tumors: Tumor Progression and Prognostic Significance
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[Abstract] [Full Text]

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 Am. J. Pathol.Home page
A. Zettl, P. Strobel, K. Wagner, T. Katzenberger, G. Ott, A. Rosenwald, K. Peters, A. Krein, M. Semik, H.-K. Muller-Hermelink, et al.
Recurrent Genetic Aberrations in Thymoma and Thymic Carcinoma
Am. J. Pathol., July 1, 2000; 157(1): 257 - 266.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
U. Lehmann, S. Glockner, W. Kleeberger, H. F. R. von Wasielewski, and H. Kreipe
Detection of Gene Amplification in Archival Breast Cancer Specimens by Laser-Assisted Microdissection and Quantitative Real-Time Polymerase Chain Reaction
Am. J. Pathol., June 1, 2000; 156(6): 1855 - 1864.
[Abstract] [Full Text] [PDF]

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 CarcinogenesisHome page
J. W. Gray and C. Collins
Genome changes and gene expression in human solid tumors
Carcinogenesis, March 1, 2000; 21(3): 443 - 452.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
L. Lin, S. Aggarwal, T. W. Glover, M. B. Orringer, S. Hanash, and D. G. Beer
A Minimal Critical Region of the 8p22-23 Amplicon in Esophageal Adenocarcinomas Defined Using Sequence Tagged Site-Amplification Mapping and Quantitative Polymerase Chain Reaction Includes the GATA-4 Gene
Cancer Res., March 1, 2000; 60(5): 1341 - 1347.
[Abstract] [Full Text]

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 Am. J. Pathol.Home page
V. Wallenius, M. Hisaoka, K. Helou, G. Levan, N. Mandahl, J. M. Meis-Kindblom, L.-G. Kindblom, and J.-O. Jansson
Overexpression of the Hepatocyte Growth Factor (HGF) Receptor (Met) and Presence of a Truncated and Activated Intracellular HGF Receptor Fragment in Locally Aggressive/Malignant Human Musculoskeletal Tumors
Am. J. Pathol., March 1, 2000; 156(3): 821 - 829.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
W.’e. El-Rifai, D. Kamel, M. L. Larramendy, S. Shoman, Y. Gad, S. Baithun, M. El-Awady, S. Eissa, H. Khaled, S. Soloneski, et al.
DNA Copy Number Changes in Schistosoma-Associated and Non-Schistosoma-Associated Bladder Cancer
Am. J. Pathol., March 1, 2000; 156(3): 871 - 878.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
M. A. Heiskanen, M. L. Bittner, Y. Chen, J. Khan, K. E. Adler, J. M. Trent, and P. S. Meltzer
Detection of Gene Amplification by Genomic Hybridization to cDNA Microarrays
Cancer Res., February 1, 2000; 60(4): 799 - 802.
[Abstract] [Full Text]

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 Proc. Natl. Acad. Sci. USAHome page
J. Herrick, X. Michalet, C. Conti, C. Schurra, and A. Bensimon
Quantifying single gene copy number by measuring fluorescent probe lengths on combed genomic DNA
PNAS, January 4, 2000; 97(1): 222 - 227.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
M. J. Riemenschneider, R. Buschges, M. Wolter, J. Reifenberger, J. Bostrom, J. A. Kraus, U. Schlegel, and G. Reifenberger
Amplification and Overexpression of the MDM4 (MDMX) Gene from 1q32 in a Subset of Malignant Gliomas without TP53 Mutation or MDM2 Amplification
Cancer Res., December 1, 1999; 59(24): 6091 - 6096.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
E. J. M. Speel, J. Richter, H. Moch, C. Egenter, P. Saremaslani, K. Rutimann, J. Zhao, A. Barghorn, J. Roth, P. U. Heitz, et al.
Genetic Differences in Endocrine Pancreatic Tumor Subtypes Detected by Comparative Genomic Hybridization
Am. J. Pathol., December 1, 1999; 155(6): 1787 - 1794.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
J. Richter, U. Wagner, P. Schraml, R. Maurer, G. Alund, H. Knonagel, H. Moch, M. J. Mihatsch, T. C. Gasser, and G. Sauter
Chromosomal Imbalances Are Associated with a High Risk of Progression in Early Invasive (pT1) Urinary Bladder Cancer
Cancer Res., November 1, 1999; 59(22): 5687 - 5691.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
N. V. Somia, M. J. Schmitt, D. E. Vetter, D. Van Antwerp, S. F. Heinemann, and I. M. Verma
LFG: An anti-apoptotic gene that provides protection from Fas-mediated cell death
PNAS, October 26, 1999; 96(22): 12667 - 12672.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
S. Knuutila, Y. Aalto, K. Autio, A.-M. Bjorkqvist, W.'e. El-Rifai, S. Hemmer, T. Huhta, E. Kettunen, S. Kiuru-Kuhlefelt, M. L. Larramendy, et al.
DNA Copy Number Losses in Human Neoplasms
Am. J. Pathol., September 1, 1999; 155(3): 683 - 694.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
P. Schraml, J. Kononen, L. Bubendorf, H. Moch, H. Bissig, A. Nocito, M. J. Mihatsch, O.-P. Kallioniemi, and G. Sauter
Tissue Microarrays for Gene Amplification Surveys in Many Different Tumor Types
Clin. Cancer Res., August 1, 1999; 5(8): 1966 - 1975.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
K. Nakatani, D. A. Thompson, A. Barthel, H. Sakaue, W. Liu, R. J. Weigel, and R. A. Roth
Up-regulation of Akt3 in Estrogen Receptor-deficient Breast Cancers and Androgen-independent Prostate Cancer Lines
J. Biol. Chem., July 30, 1999; 274(31): 21528 - 21532.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
H. Bissig, J. Richter, R. Desper, V. Meier, P. Schraml, A. A. Schaffer, G. Sauter, M. J. Mihatsch, and H. Moch
Evaluation of the Clonal Relationship between Primary and Metastatic Renal Cell Carcinoma by Comparative Genomic Hybridization
Am. J. Pathol., July 1, 1999; 155(1): 267 - 274.
[Abstract] [Full Text] [PDF]

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 BloodHome page
S. Bea, M. Ribas, J. M. Hernandez, F. Bosch, M. Pinyol, L. Hernandez, J. L. Garcia, T. Flores, M. Gonzalez, A. Lopez-Guillermo, et al.
Increased Number of Chromosomal Imbalances and High-Level DNA Amplifications in Mantle Cell Lymphoma Are Associated With Blastoid Variants
Blood, June 15, 1999; 93(12): 4365 - 4374.
[Abstract] [Full Text] [PDF]

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 Genome ResHome page
D. Vollrath and V. L. Jaramillo-Babb
A Sequence-Ready BAC Clone Contig of a 2.2-Mb Segment of Human Chromosome 1q24
Genome Res., February 1, 1999; 9(2): 150 - 157.
[Abstract] [Full Text]

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 Cancer Res.Home page
H. van Dekken, E. Geelen, W. N. M. Dinjens, B. P. L. Wijnhoven, H. W. Tilanus, H. J. Tanke, and C. Rosenberg
Comparative Genomic Hybridization of Cancer of the Gastroesophageal Junction: Deletion of 14Q31-32.1 Discriminates between Esophageal (Barrett's) and Gastric Cardia Adenocarcinomas
Cancer Res., February 1, 1999; 59(3): 748 - 752.
[Abstract] [Full Text] [PDF]

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 Genome ResHome page
C. Collins, S. Volik, D. Kowbel, D. Ginzinger, B. Ylstra, T. Cloutier, T. Hawkins, P. Predki, C. Martin, M. Wernick, et al.
Comprehensive Genome Sequence Analysis of a Breast Cancer Amplicon
Genome Res., June 1, 2001; 11(6): 1034 - 1042.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
N. Solban, H.-P. Jia, S. Richard, S. Tremblay, A. M. Devlin, J. Peng, F. Gossard, D.-F. Guo, G. Morel, P. Hamet, et al.
HCaRG, a Novel Calcium-regulated Gene Coding for a Nuclear Protein, Is Potentially Involved in the Regulation of Cell Proliferation
J. Biol. Chem., October 6, 2000; 275(41): 32234 - 32243.
[Abstract] [Full Text] [PDF]


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