| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 152, 1377-1386, Copyright © 1998 by American Society for Investigative Pathology
REGULAR ARTICLES |
DJ Berg, NA Lynch, RG Lynch and DM Lauricella
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA. daniel-j-berg@uiowa.edu
Interleukin (IL)-10 is a potent anti-inflammatory and immune-regulatory cytokine. Mice deficient in IL-10 production (IL-10(-/-)) develop a spontaneous inflammatory bowel disease, indicating that IL-10 is an important regulator of the mucosal immune response in vivo. To study the role of IL-10 in the host response to gastric Helicobacter infection, stomachs of IL-10(-/-) and wild-type mice were colonized with Helicobacter felis, as a model of human H. pylori infection. Within 4 weeks of H. felis infection, wild-type mice develop a mild, focal chronic gastritis. In contrast, H. felis-infected IL-10(-/-) mice develop a severe hyperplastic gastritis, characterized by a dense, predominantly mononuclear cell inflammation of the mucosa and submucosa and epithelial cell proliferation and dedifferentiation. Within 4 weeks of H. felis infection, there are striking alterations in the character of the gastric epithelium from IL-10(-/-) mice, including a profound loss of parietal and chief cells, focal de novo production of acidic mucins, and marked epithelial proliferation with disordered epithelial architecture. These findings indicate that, in the absence of IL-10, the inflammatory and immunological responses of the murine host to gastric colonization with Helicobacter is a rapidly evolving pathological process with features that mimic those associated with H. pylori infection in humans. H. felis-infected IL-10(-/-) mice may provide a model with which to investigate the cellular and molecular changes that stem from gastric infection with H. pylori.
This article has been cited by other articles:
 |
|
 |
|
  S. Narushima, D. DiMeo, J. Tian, J. Zhang, D. Liu, and D. J. Berg 5-Lipoxygenase-derived lipid mediators are not required for the development of NSAID-induced inflammatory bowel disease in IL-10-/- mice Am J Physiol Gastrointest Liver Physiol, February 1, 2008; 294(2): G477 - G488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Fox, A. B. Rogers, M. T. Whary, Z. Ge, M. Ohtani, E. K. Jones, and T. C. Wang Accelerated Progression of Gastritis to Dysplasia in the Pyloric Antrum of TFF2 / C57BL6 x Sv129 Helicobacter pylori-Infected Mice Am. J. Pathol., November 1, 2007; 171(5): 1520 - 1528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-W. Lee, V. P. Rao, A. B. Rogers, Z. Ge, S. E. Erdman, M. T. Whary, and J. G. Fox Wild-Type and Interleukin-10-Deficient Regulatory T Cells Reduce Effector T-Cell-Mediated Gastroduodenitis in Rag2-/- Mice, but Only Wild-Type Regulatory T Cells Suppress Helicobacter pylori Gastritis Infect. Immun., June 1, 2007; 75(6): 2699 - 2707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. S. Algood and T. L. Cover Helicobacter pylori Persistence: an Overview of Interactions between H. pylori and Host Immune Defenses Clin. Microbiol. Rev., October 1, 2006; 19(4): 597 - 613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Drakes, S. J. Czinn, and T. G. Blanchard Regulation of Murine Dendritic Cell Immune Responses by Helicobacter felis Antigen. Infect. Immun., August 1, 2006; 74(8): 4624 - 4633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Eaton, L. H. Benson, J. Haeger, and B. M. Gray Role of Transcription Factor T-bet Expression by CD4+ Cells in Gastritis Due to Helicobacter pylori in Mice. Infect. Immun., August 1, 2006; 74(8): 4673 - 4684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Sommer, H. Wilken, G. Faller, and M. Lohoff Systemic Th1 Immunization of Mice against Helicobacter pylori Infection with CpG Oligodeoxynucleotides as Adjuvants Does Not Protect from Infection but Enhances Gastritis Infect. Immun., February 1, 2004; 72(2): 1029 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. F. Ismail, J. Zhang, R. G. Lynch, Y. Wang, and D. J. Berg Role for Complement in Development of Helicobacter-Induced Gastritis in Interleukin-10-Deficient Mice Infect. Immun., December 1, 2003; 71(12): 7140 - 7148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. F. Ismail, P. Fick, J. Zhang, R. G. Lynch, and D. J. Berg Depletion of Neutrophils in IL-10-/- Mice Delays Clearance of Gastric Helicobacter Infection and Decreases the Th1 Immune Response to Helicobacter J. Immunol., April 1, 2003; 170(7): 3782 - 3789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Eaton, M. Mefford, and T. Thevenot The Role of T Cell Subsets and Cytokines in the Pathogenesis of Helicobacter pylori Gastritis in Mice J. Immunol., June 15, 2001; 166(12): 7456 - 7461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Bodger, K Bromelow, J I Wyatt, and R V Heatley Interleukin 10 in Helicobacter pylori associated gastritis: immunohistochemical localisation and in vitro effects on cytokine secretion J. Clin. Pathol., April 1, 2001; 54(4): 285 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Berg, J. Zhang, D. M. Lauricella, and S. A. Moore IL-10 Is a Central Regulator of Cyclooxygenase-2 Expression and Prostaglandin Production J. Immunol., February 15, 2001; 166(4): 2674 - 2680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. V. Solnick and D. B. Schauer Emergence of Diverse Helicobacter Species in the Pathogenesis of Gastric and Enterohepatic Diseases Clin. Microbiol. Rev., January 1, 2001; 14(1): 59 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Meyer, K. T. Wilson, and S. P. James Modulation of Innate Cytokine Responses by Products of Helicobacter pylori Infect. Immun., November 1, 2000; 68(11): 6265 - 6272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sutton, T. Kolesnikow, S. Danon, J. Wilson, and A. Lee Dominant Nonresponsiveness to Helicobacter pylori Infection Is Associated with Production of Interleukin 10 but Not Gamma Interferon Infect. Immun., August 1, 2000; 68(8): 4802 - 4804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Eaton, S. R. Ringler, and S. J. Danon Murine Splenocytes Induce Severe Gastritis and Delayed-Type Hypersensitivity and Suppress Bacterial Colonization in Helicobacter pylori-Infected SCID Mice Infect. Immun., September 1, 1999; 67(9): 4594 - 4602. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
