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American Journal of Pathology, Vol 152, 1531-1539, Copyright © 1998 by American Society for Investigative Pathology

REGULAR ARTICLES

Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy

M Perez, JM Valpuesta, EM de Garcini, C Quintana, M Arrasate, JL Lopez Carrascosa, A Rabano, J Garcia de Yebenes and J Avila
Centro de Biologia Molecular Severo Ochoa Universidad Autonoma de Madrid, Spain.

Tau-containing filaments purified from the brain of progressive supranuclear palsy (PSP) patients were isolated and characterized. These filaments co-purify with regular particles that biophysical and biochemical methods identified as ferritin shells. In vivo, brain tau accumulation in PSP co-localized with ferritin. These results suggest that ferritin/iron could modulate the formation of tau aggregates in PSP.




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Copyright © 1998 by the American Society for Investigative Pathology.