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Short Communications |
(PPAR) and Its Coactivators Steroid Receptor Coactivator-1 and PPAR-Binding Protein PBP in the Brown Fat, Urinary Bladder, Colon, and Breast of the Mouse
From the Department of Pathology, Northwestern University Medical School, Chicago, Illinois
Peroxisome proliferator-activated receptors (PPARs) regulate genes
involved in lipid metabolism and adipocyte differentiation. Steroid
receptor coactivator-1 (SRC-1) and PPAR-binding protein (PBP) interact
with PPAR
and act as coactivators to enhance ligand-dependent
transcription. We report here that PPAR, SRC-1, and
PBP are differentially expressed in the brown fat, transitional
epithelium of the urinary bladder, colonic mucosa, and
mammary epithelium of the adult mouse. PPAR and PBP are expressed in
the transitional epithelium of urinary bladder and in brown adipose
tissue, but not SRC-1. In the colonic mucosa, PPAR
expression occurs throughout the villi, whereas the expression
of both SRC-1 and PBP is confined mostly to the crypts. The expression
of both SRC-1 and PBP is prominent in the breast epithelium of
nonpregnant, pregnant, and lactating mice,
whereas PPAR expression appeared prominent during lactation. During
early embryonic development, PPAR, SRC-1,
and PBP are differentially expressed, with only limited cell
types displaying overlapping expression. PPAR and PBP expression
overlapped in the brown fat and urogenital sinus at stage E15.5 of
embryogenesis, whereas SRC-1 expression occurred mostly in
neuroepithelium and cartilage between stages E9.5 and E13.5 of
embryogenesis.
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