help button home button Am J Pathol ASIP WHAT IS IT?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xie, W.
Right arrow Articles by Wu, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xie, W.
Right arrow Articles by Wu, C.
(American Journal of Pathology. 1998;153:367-372.)
© 1998 American Society for Investigative Pathology

Short Communications

Expression of the Integrin-Linked Kinase (ILK) in Mouse Skin

Loss of Expression in Suprabasal Layers of the Epidermis andUp-Regulation by erbB-2

Wen Xie*{dagger} , Fugang Li*{ddagger} , Jeffrey E. Kudlow*{dagger} and Chuanyue Wu*{ddagger}

From the Departments of Cell Biology * and Medicine {dagger} , and the Cell Adhesion and Matrix Research Center {ddagger} , University of Alabama at Birmingham, Birmingham, Alabama

Integrin-linked kinase (ILK) is a newly identified serine/threonine protein kinase implicated in integrin signaling. To investigate the functions of ILK in vivo, we have analyzed the expression and regulation of ILK in the skin, in which proper control of cell-extracellular matrix interactions and cell proliferation is essential for its normal development and homeostasis. We report here that ILK is abundantly expressed throughout the extracellular matrix-rich dermis. ILK mRNA was also detected in the hair follicles and the basal cells of the interfollicular epidermis. However, ILK expression is lost in the suprabasal layers of keratinocytes that are undergoing terminal differentiation. PINCH, an ILK-binding protein, exhibited a similar expression pattern in the skin. Recent studies have indicated that erbB-2, a member of the epidermal growth factor receptor family, plays a pivotal role in epidermal growth, differentiation, and hair follicle morphogenesis. Using a transgenic mouse system in which an activated erbB-2 is overexpressed in the epidermis, we show that ILK expression is regulated by erbB-2. The in vivo expression and regulation patterns of ILK, together with its biochemical activities, suggest an important role of ILK in coordinating the integrin signaling pathways and the growth factor signaling pathways in the development of the skin and the pathogenesis of skin diseases.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
Y. Yang, M.-P. Tetreault, Y. A. Yermolina, B. G. Goldstein, and J. P. Katz
Kruppel-like Factor 5 Controls Keratinocyte Migration via the Integrin-linked Kinase
J. Biol. Chem., July 4, 2008; 283(27): 18812 - 18820.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A Somasiri, A Howarth, D Goswami, S Dedhar, and C. Roskelley
Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells
J. Cell Sci., January 3, 2001; 114(6): 1125 - 1136.
[Abstract] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Tu, F. Li, S. Goicoechea, and C. Wu
The LIM-Only Protein PINCH Directly Interacts with Integrin-Linked Kinase and Is Recruited to Integrin-Rich Sites in Spreading Cells
Mol. Cell. Biol., March 1, 1999; 19(3): 2425 - 2434.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C Wu
Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction
J. Cell Sci., January 12, 1999; 112(24): 4485 - 4489.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
F Li, Y Zhang, and C Wu
Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats
J. Cell Sci., January 12, 1999; 112(24): 4589 - 4599.
[Abstract] [PDF]

Home page
 Mol. Biol. CellHome page
Y. Tu, F. Li, and C. Wu
Nck-2, a Novel Src Homology2/3-containing Adaptor Protein That Interacts with the LIM-only Protein PINCH and Components of Growth Factor Receptor Kinase-signaling Pathways
Mol. Biol. Cell, December 1, 1998; 9(12): 3367 - 3382.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Society for Investigative Pathology.