| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
From the Department of Medical Sciences,*
Section of
Hematology, and Department of
Pathology,
University of Modena, Modena,
Italy; PathoGenesis Corporation,
Seattle,
Washington; and Department of Biomedicine,§
Section of Virology, University of Pisa, Pisa, Italy
Immunohistochemistry was used to look for the expression of human herpesvirus-6 (HHV-6) antigens in a well characterized series of benign, atypical, and malignant lymphoid lesions, which tested positive for the presence of HHV-6 DNA. A panel of specific antibodies against HHV-6 antigens, characteristic either of the early (p41) or late (p101K, gp106, and gp116) phases of the viral cycle, was applied to the lymphoid tissues from 15 non-Hodgkin's lymphomas, 14 Hodgkin's disease cases, 5 angioimmunoblastic lymphadenopathies with dysproteinemia, 14 reactive lymphadenopathies, and 2 cases of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). In lymphomatous tissues, the expression of late antigens was documented only in reactive cells, and mainly in plasma cells. Of interest, the expression of the early p41 antigen was detected in the so-called "mummified" Reed-Sternberg cells, in two Hodgkin's disease cases. In reactive lymphadenopathies, the HHV-6 late antigen-expressing cells were plasma cells, histiocytes, and rare granulocytes distributed in interfollicular areas. In both cases of Rosai-Dorfman disease, the p101K showed an intense staining in follicular dendritic cells of germinal centers, whereas the gp106 exhibited an intense cytoplasmic reaction in the abnormal histiocytes, which represent the histological hallmark of the disease. The expression of HHV-6 antigens is tightly controlled in lymphoid tissues. The lack of HHV-6 antigen expression in neoplastic cells and the limited expression in degenerating Reed-Sternberg cells argue against a major pathogenetic role of the virus in human lymphomagenesis. The detection of a rather unique pattern of viral late antigen expression in Rosai-Dorfman disease suggests a possible pathogenetic involvement of HHV-6 in some cases of this rare lymphoproliferative disorder.
This article has been cited by other articles:
 |
|
 |
|
  Radiology Quiz Case 2: Diagnosis Arch Otolaryngol Head Neck Surg, March 1, 2009; 135(3): 319 - 319. [Full Text] [PDF]
|
|
|
|
 |
|
 S Paradela, J Lorenzo, W Martinez-Gomez, T Yebra-Pimentel, L Valbuena, and E Fonseca Interface dermatitis in skin lesions of Kikuchi-Fujimoto's disease: a histopathological marker of evolution into systemic lupus erythematosus? Lupus, December 1, 2008; 17(12): 1127 - 1135. [Abstract] [PDF]
|
|
|
|
 |
|
 L. Potenza, M. Luppi, P. Barozzi, G. Rossi, S. Cocchi, M. Codeluppi, M. Pecorari, M. Masetti, F. Di Benedetto, W. Gennari, et al. HHV-6A in Syncytial Giant-Cell Hepatitis N. Engl. J. Med., August 7, 2008; 359(6): 593 - 602. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Mehraein, M Wagner, K Remberger, L Fuzesi, P Middel, S Kaptur, K Schmitt, and E Meese Parvovirus B19 detected in Rosai-Dorfman disease in nodal and extranodal manifestations J. Clin. Pathol., December 1, 2006; 59(12): 1320 - 1326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Pathology Quiz Case: Diagnosis Arch Otolaryngol Head Neck Surg, April 1, 2006; 132(4): 456 - 456. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Alatassi, M. B. Ray, S. Galandiuk, and S. Sahoo Rosai-Dorfman Disease of the Gastrointestinal Tract: Report of a Case and Review of the Literature International Journal of Surgical Pathology, January 1, 2006; 14(1): 95 - 99. [Abstract] [PDF]
|
|
|
|
 |
|
 L. De Bolle, L. Naesens, and E. De Clercq Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy Clin. Microbiol. Rev., January 1, 2005; 18(1): 217 - 245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. McClain, Y. Natkunam, and S. H. Swerdlow Atypical Cellular Disorders Hematology, January 1, 2004; 2004(1): 283 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Collot, B. Petit, D. Bordessoule, S. Alain, M. Touati, F. Denis, and S. Ranger-Rogez Real-Time PCR for Quantification of Human Herpesvirus 6 DNA from Lymph Nodes and Saliva J. Clin. Microbiol., July 1, 2002; 40(7): 2445 - 2451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Asada, V. Klaus-Kovtun, H. Golding, S. I. Katz, and A. Blauvelt Human Herpesvirus 6 Infects Dendritic Cells and Suppresses Human Immunodeficiency Virus Type 1 Replication in Coinfected Cultures J. Virol., May 1, 1999; 73(5): 4019 - 4028. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
