help button home button Am J Pathol International Conference on Pathology of Chest Diseases
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alderuccio, F.
Right arrow Articles by Toh, B. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alderuccio, F.
Right arrow Articles by Toh, B. H.
(American Journal of Pathology. 1998;153:1311-1318.)
© 1998 American Society for Investigative Pathology

Animal Model

Spontaneous Autoimmune Gastritis in C3H/He Mice

A New Mouse Model for Gastric Autoimmunity

Frank Alderuccio and Ban Hock Toh

From the Department of Pathology and Immunology, Monash University Medical School, Prahran, Victoria, Australia

Autoimmune gastritis is the underlying pathological lesion of pernicious anemia in humans. The lesion is characterized by a chronic inflammatory infiltrate in the gastric mucosa with loss of parietal and zymogenic cells. It is associated with circulating autoantibodies to the gastric H/K-ATPase, the enzyme responsible for acidification of gastric juice. Experimental models of autoimmune gastritis have previously been produced in mice after a variety of manipulations, including thymectomy. Here we report for the first time a spontaneous mouse model of autoimmune gastritis in C3H/He mice. The spontaneous gastritis is also accompanied by circulating autoantibodies to the gastric H/K-ATPase. The spontaneous mouse model should be useful for studies directed toward the immunopathogenesis and treatment of autoimmune gastritis.




This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
T. Dohi, K. Fujihashi, T. Koga, Y. Etani, N. Yoshino, Y. I. Kawamura, and J. R. McGhee
CD4+CD45RBHi Interleukin-4 Defective T Cells Elicit Antral Gastritis and Duodenitis
Am. J. Pathol., October 1, 2004; 165(4): 1257 - 1268.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Biondo, Z. Nasa, A. Marshall, B. Hock Toh, and F. Alderuccio
Local Transgenic Expression of Granulocyte Macrophage-Colony Stimulating Factor Initiates Autoimmunity
J. Immunol., February 1, 2001; 166(3): 2090 - 2099.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
F. Alderuccio, V. Cataldo, I. R. van Driel, P. A. Gleeson, and B. H. Toh
Tolerance and autoimmunity to a gastritogenic peptide in TCR transgenic mice
Int. Immunol., March 1, 2000; 12(3): 343 - 352.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Society for Investigative Pathology.