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(American Journal of Pathology. 1998;153:1701-1705.)
© 1998 American Society for Investigative Pathology

Short Communications

Homing Receptor {alpha}4ß7 Integrin Expression Predicts Digestive Tract Involvement in Mantle Cell Lymphoma

Frédéric Geissmann* , Agnès Ruskoné-Fourmestraux{ddagger} , Olivier Hermine{dagger} , Priscille Bourquelot{dagger} , Coralie Belanger{dagger} , José Audouin¶ , Alain Delmer§ , Elisabeth A. Macintyre{dagger} , Bruno Varet{dagger} and Nicole Brousse*

From the Departments of Pathology* (FG, NB) and Hematology,{dagger} Hôpital Necker-Enfants Malades, Université René Descartes-Paris EA 219, and the Departments of Internal Medecine,{ddagger} Hematology,§ and Pathology,¶ Hôtel-Dieu, Paris, France

Appropriate staging and evaluation of residual disease is critical to improving the treatment of patients with lymphoma. The specific expression of homing receptors may determine the preferential dissemination pattern of tumoral cells. We investigated the expression of the mucosal homing receptor {alpha}4ß7 on tumoral cells from peripheral lymph node in patients with newly diagnosed mantle cell lymphoma (MCL) to check whether it is associated with gastrointestinal involvement. Expression of the {alpha}4ß1 integrin and the peripheral lymph node addressin CD62L were also examined. Thirteen MCL patients presenting with peripheral lymphadenopathy were studied. Expression of the mucosal homing receptor integrin {alpha}4ß7 by peripheral lymph node lymphoma cells was found to be frequent (5/13) and associated with gastrointestinal involvement (5/7). In contrast, lymphoma cells from patients without gastrointestinal involvement did not express {alpha}4ß7 (6/6) (P = 0.03). These data suggest that {alpha}4ß7 integrin is expressed by a subset of MCLs and that its expression may predict digestive tract involvement in MCL, furnishing a basis for recognizing two distinct clinical and phenotypic forms, ie, "digestive homing (or digestive primitive)" versus "peripheral" MCL. Further studies on more patients will be needed to understand the impact of biological differences on the prognosis of these two clinical forms.




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Copyright © 1998 by the American Society for Investigative Pathology.