| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
B Activation and Augmentation of IBß by Secretory Leukocyte Protease Inhibitor during Lung Inflammation
From the Department of Surgery,*
University of
Louisville School of Medicine, Louisville, Kentucky; the Departments of
Pathology and
Surgery,
University of Michigan Medical
School, Ann Arbor, Michigan; and the Department of Trauma
Surgery,§
University of Freiburg,
Freiburg/Breisgau, Germany
In earlier experiments, exogenous administration of
secretory leukocyte protease inhibitor (SLPI) suppressed acute lung
injury induced by deposition of IgG immune complexes. In the current
studies we examined the mechanism of the protective effects of SLPI in
this model. The presence of SLPI in the IgG immune complex-model of
lung injury reduced the increase in extravascular leakage of
125I-albumin, the intensity of up-regulation of
lung vascular intercellular adhesion molecule-1, and the
numbers of neutrophils accumulating in the lung. The presence of SLPI
caused greatly reduced activation (ie, nuclear translocation)
of the transcription nuclear factor-
B (NF-B) in lung cells but
did not suppress activation of lung mitogen-activated protein kinase.
SLPI did not alter NF-B activation in alveolar macrophages harvested
30 minutes after initiation of lung inflammation. In the presence of
SLPI, content of tumor necrosis factor-
, CXC
chemokines, and C5a in bronchoalveolar fluids was unaffected.
In the inflamed lungs, inhibition of NF-B activation by SLPI
was associated with elevated levels of lung IBß (but not IB)
protein in the absence of elevated mRNA for IBß. When instilled
into normal lung, SLPI also caused similar changes (increases)
in lung IBß. Finally, in the lung inflammatory model
used, the presence of anti-SLPI caused accentuated activation
of NF-B. These data confirm the anti-inflammatory effect of SLPI in
lung and point to a mechanism of anti-inflammatory effects of SLPI.
SLPI appears to function as an endogenous regulator of lung
inflammation.
This article has been cited by other articles:
 |
|
 |
|
  A. W Horne, S. J Stock, and A. E King Innate immunity and disorders of the female reproductive tract Reproduction, June 1, 2008; 135(6): 739 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Geraghty, C. M. Greene, M. O'Mahony, S. J. O'Neill, C. C. Taggart, and N. G. McElvaney Secretory Leucocyte Protease Inhibitor Inhibits Interferon-{gamma}-induced Cathepsin S Expression J. Biol. Chem., November 16, 2007; 282(46): 33389 - 33395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Samsom, A. P. J. van der Marel, L. A. van Berkel, J. M. L. M. van Helvoort, Y. Simons-Oosterhuis, W. Jansen, M. Greuter, R. L. H. Nelissen, C. M. L. Meeuwisse, E. E. S. Nieuwenhuis, et al. Secretory Leukoprotease Inhibitor in Mucosal Lymph Node Dendritic Cells Regulates the Threshold for Mucosal Tolerance J. Immunol., November 15, 2007; 179(10): 6588 - 6595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Auguste, L. Fallavollita, N. Wang, J. Burnier, A. Bikfalvi, and P. Brodt The Host Inflammatory Response Promotes Liver Metastasis by Increasing Tumor Cell Arrest and Extravasation Am. J. Pathol., May 1, 2007; 170(5): 1781 - 1792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Wang, T. Thuraisingam, L. Fallavollita, A. Ding, D. Radzioch, and P. Brodt The Secretory Leukocyte Protease Inhibitor Is a Type 1 Insulin-Like Growth Factor Receptor-Regulated Protein that Protects against Liver Metastasis by Attenuating the Host Proinflammatory Response. Cancer Res., March 15, 2006; 66(6): 3062 - 3070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Taggart, S.-A. Cryan, S. Weldon, A. Gibbons, C. M. Greene, E. Kelly, T. B. Low, S. J. O'Neill, and N. G. McElvaney Secretory leucoprotease inhibitor binds to NF-{kappa}B binding sites in monocytes and inhibits p65 binding J. Exp. Med., December 19, 2005; 202(12): 1659 - 1668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Iizuka, Y. Ishii, K. Itoh, T. Kiwamoto, T. Kimura, Y. Matsuno, Y. Morishima, A. E. Hegab, S. Homma, A. Nomura, et al. Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema Genes Cells, December 1, 2005; 10(12): 1113 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ishii, K. Itoh, Y. Morishima, T. Kimura, T. Kiwamoto, T. IIzuka, A. E. Hegab, T. Hosoya, A. Nomura, T. Sakamoto, et al. Transcription Factor Nrf2 Plays a Pivotal Role in Protection against Elastase-Induced Pulmonary Inflammation and Emphysema J. Immunol., November 15, 2005; 175(10): 6968 - 6975. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M C Velarde, S I Parisek, R R Eason, F A Simmen, and R C M Simmen The secretory leukocyte protease inhibitor gene is a target of epidermal growth factor receptor action in endometrial epithelial cells J. Endocrinol., January 1, 2005; 184(1): 141 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lee, Y.-S. Kim, D.-H. Choi, M. S. Bang, T. R. Han, T. H. Joh, and S.-Y. Kim Transglutaminase 2 Induces Nuclear Factor-{kappa}B Activation via a Novel Pathway in BV-2 Microglia J. Biol. Chem., December 17, 2004; 279(51): 53725 - 53735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. DEVOOGDT, H. REVETS, G. H. GHASSABEH, and P. DE BAETSELIER Secretory Leukocyte Protease Inhibitor in Cancer Development Ann. N.Y. Acad. Sci., December 1, 2004; 1028(1): 380 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Heckel, R. Kiefmann, M. Dorger, M. Stoeckelhuber, and A. E. Goetz Colloidal gold particles as a new in vivo marker of early acute lung injury Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L867 - L878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Greene, N. G. McElvaney, S. J. O'Neill, and C. C. Taggart Secretory Leucoprotease Inhibitor Impairs Toll-Like Receptor 2- and 4-Mediated Responses in Monocytic Cells Infect. Immun., June 1, 2004; 72(6): 3684 - 3687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Henriksen, M. Hitt, Z. Xing, J. Wang, C. Haslett, R. A. Riemersma, D. J. Webb, Y. V. Kotelevtsev, and J.-M. Sallenave Adenoviral Gene Delivery of Elafin and Secretory Leukocyte Protease Inhibitor Attenuates NF-{kappa}B-Dependent Inflammatory Responses of Human Endothelial Cells and Macrophages to Atherogenic Stimuli J. Immunol., April 1, 2004; 172(7): 4535 - 4544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Parker and M. I. Townsley Evaluation of lung injury in rats and mice Am J Physiol Lung Cell Mol Physiol, February 1, 2004; 286(2): L231 - L246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Odaka, T. Mizuochi, J. Yang, and A. Ding Murine Macrophages Produce Secretory Leukocyte Protease Inhibitor During Clearance of Apoptotic Cells: Implications for Resolution of the Inflammatory Response J. Immunol., August 1, 2003; 171(3): 1507 - 1514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Churg, R. D. Wang, C. Xie, and J. L. Wright {alpha}-1-Antitrypsin Ameliorates Cigarette Smoke-induced Emphysema in the Mouse Am. J. Respir. Crit. Care Med., July 15, 2003; 168(2): 199 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Sallenave, G. A. Cunningham, R. M. James, G. McLachlan, and C. Haslett Regulation of Pulmonary and Systemic Bacterial Lipopolysaccharide Responses in Transgenic Mice Expressing Human Elafin Infect. Immun., July 1, 2003; 71(7): 3766 - 3774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Devoogdt, G. Hassanzadeh Ghassabeh, J. Zhang, L. Brys, P. De Baetselier, and H. Revets Secretory leukocyte protease inhibitor promotes the tumorigenic and metastatic potential of cancer cells PNAS, May 13, 2003; 100(10): 5778 - 5782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Mizgerd, M. L. Scott, M. R. Spieker, and C. M. Doerschuk Functions of I{kappa}B Proteins in Inflammatory Responses to Escherichia coli LPS in Mouse Lungs Am. J. Respir. Cell Mol. Biol., November 1, 2002; 27(5): 575 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Spector, D. Li, W. Ma, F. Sun, and P. Pavlidis Differential Amplification of Gene Expression in Lens Cell Lines Conditioned to Survive Peroxide Stress Invest. Ophthalmol. Vis. Sci., October 1, 2002; 43(10): 3251 - 3264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Wright, S. G. Farmer, and A. Churg Synthetic Serine Elastase Inhibitor Reduces Cigarette Smoke-induced Emphysema in Guinea Pigs Am. J. Respir. Crit. Care Med., October 1, 2002; 166(7): 954 - 960. [Abstract] [Full Text]
|
|
|
|
|
|
C. C. Taggart, C. M. Greene, N. G. McElvaney, and S. O'Neill Secretory Leucoprotease Inhibitor Prevents Lipopolysaccharide-induced Ikappa Balpha Degradation without Affecting Phosphorylation or Ubiquitination J. Biol. Chem., September 6, 2002; 277(37): 33648 - 33653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zhang, R. C. M. Simmen, F. J. Michel, G. Zhao, D. Vale-Cruz, and F. A. Simmen Secretory Leukocyte Protease Inhibitor Mediates Proliferation of Human Endometrial Epithelial Cells by Positive and Negative Regulation of Growth-associated Genes J. Biol. Chem., August 9, 2002; 277(33): 29999 - 30009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. King, D. C. Fleming, H. O.D. Critchley, and R. W. Kelly Regulation of natural antibiotic expression by inflammatory mediators and mimics of infection in human endometrial epithelial cells Mol. Hum. Reprod., April 1, 2002; 8(4): 341 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Paparella, T.M. Yau, and E. Young Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update Eur. J. Cardiothorac. Surg., February 1, 2002; 21(2): 232 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Kupfner, J. J. Arcaroli, H.-K. Yum, S. G. Nadler, K.-Y. Yang, and E. Abraham Role of NF-{kappa}B in Endotoxemia-Induced Alterations of Lung Neutrophil Apoptosis J. Immunol., December 15, 2001; 167(12): 7044 - 7051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-F. Guo, A. B. Lentsch, R. L. Warner, M. Huber-Lang, J. V. Sarma, T. Hlaing, M. M. Shi, N. W. Lukacs, and P. A. Ward Regulatory Effects of Eotaxin on Acute Lung Inflammatory Injury J. Immunol., April 15, 2001; 166(8): 5208 - 5218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bureau, S. Delhalle, G. Bonizzi, L. Fievez, S. Dogne, N. Kirschvink, A. Vanderplasschen, M.-P. Merville, V. Bours, and P. Lekeux Mechanisms of Persistent NF-{kappa}B Activity in the Bronchi of an Animal Model of Asthma J. Immunol., November 15, 2000; 165(10): 5822 - 5830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Mulligan, A. B. Lentsch, M. Huber-Lang, R.-F. Guo, V. Sarma, C. D. Wright, T. R. Ulich, and P. A. Ward Anti-Inflammatory Effects of Mutant Forms of Secretory Leukocyte Protease Inhibitor Am. J. Pathol., March 1, 2000; 156(3): 1033 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dhami, B. Gilks, C. Xie, K. Zay, J. L. Wright, and A. Churg Acute Cigarette Smoke-Induced Connective Tissue Breakdown Is Mediated by Neutrophils and Prevented by alpha 1-Antitrypsin Am. J. Respir. Cell Mol. Biol., February 1, 2000; 22(2): 244 - 252. [Abstract] [Full Text]
|
|
|
|
|
|
X.-y. Song, L. Zeng, W. Jin, J. Thompson, D. E. Mizel, K.-j. Lei, R.C. Billinghurst, A. R. Poole, and S. M. Wahl Secretory Leukocyte Protease Inhibitor Suppresses the Inflammation and Joint Damage of Bacterial Cell Wall–induced Arthritis J. Exp. Med., August 16, 1999; 190(4): 535 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, G. W. Peet, D. Balzarano, X. Li, P. Massa, R. W. Barton, and K. B. Marcu Novel NEMO/Ikappa B Kinase and NF-kappa B Target Genes at the Pre-B to Immature B Cell Transition J. Biol. Chem., May 18, 2001; 276(21): 18579 - 18590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Taggart, G. J. Lowe, C. M. Greene, A. T. Mulgrew, S. J. O'Neill, R. L. Levine, and N. G. McElvaney Cathepsin B, L, and S Cleave and Inactivate Secretory Leucoprotease Inhibitor J. Biol. Chem., August 31, 2001; 276(36): 33345 - 33352. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
