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From the Department of Immunology, The Scripps Research Institute, La Jolla, California
Keratinocyte growth factor, (KGF), a member of the
fibroblast growth factor (FGF) family, is involved in wound
healing. It also promotes the differentiation of many epithelial
tissues and proliferation of epithelial cells as well as pancreatic
duct cells. Additionally, many members of the highly homologous
FGF family (including KGF), influence both growth and cellular
morphology in the developing embryo. We have previously observed
elevated levels of KGF in our interferon-
transgenic mouse model of
pancreatic regeneration. To understand the role of KGF in pancreatic
differentiation, we generated insulin promoter-regulated KGF
transgenic mice. Remarkably, we have found that ectopic KGF
expression resulted in the emergence of hepatocytes within the islets
of Langerhans in the pancreas. Additionally, significant
intra-islet duct cell proliferation in the pancreata of transgenic KGF
mice was observed. The unexpected appearance of hepatocytes and
proliferation of intra-islet duct cells in the pancreata of these mice
evidently stemmed directly from local exposure to KGF.
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