| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
From the Department of Clinical Pathology,*
University
of Vienna, Vienna, Austria, and the Institut für
Diabetesforschung,
Munich, Germany
Focal segmental glomerulosclerosis is a steroid-resistant glomerular disease characterized by foot process flattening and heavy proteinuria. A similar disease was found to occur spontaneously in mice in which the Mpv17 gene was inactivated by retroviral insertion (Mpv17-/- mice). Here evidence is provided that glomerular damage in this murine model is due to overproduction of oxygen radicals and accumulation of lipid peroxidation adducts that were found in isolated glomeruli of Mpv17-/- mice. The development of glomerular disease in Mpv17-/- mice was inhibited by scavengers of oxygen radicals (dithiomethylurea) and lipid peroxidation (probucol), but not by steroid treatment. Although the glomerular polyanion was greatly reduced in proteinuric Mpv17-/- mice, it was preserved by antioxidative therapy. These results indicate that the glomerular disease in Mpv17-/- mice qualifies as a model of steroid-resistant focal segmental glomerulosclerosis and that experimental therapies with scavengers of oxygen radicals and lipid peroxidation efficiently ameliorate glomerular damage.
This article has been cited by other articles:
 |
|
 |
|
  S. Zheng, E. C. Carlson, L. Yang, P. M. Kralik, Y. Huang, and P. N. Epstein Podocyte-Specific Overexpression of the Antioxidant Metallothionein Reduces Diabetic Nephropathy J. Am. Soc. Nephrol., November 1, 2008; 19(11): 2077 - 2085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Tipping Are Podocytes Passive or Provocative in Proteinuric Glomerular Pathology? J. Am. Soc. Nephrol., April 1, 2008; 19(4): 651 - 653. [Full Text] [PDF]
|
|
|
|
|
|
L. Musante, G. Candiano, A. Petretto, M. Bruschi, N. Dimasi, G. Caridi, B. Pavone, P. Del Boccio, M. Galliano, A. Urbani, et al. Active Focal Segmental Glomerulosclerosis Is Associated with Massive Oxidation of Plasma Albumin J. Am. Soc. Nephrol., March 1, 2007; 18(3): 799 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Bek, M. Bayer, B. Muller, S. Greiber, D. Lang, A. Schwab, C. August, E. Springer, R. Rohrbach, T. B. Huber, et al. Expression and Function of C/EBP Homology Protein (GADD153) in Podocytes Am. J. Pathol., January 1, 2006; 168(1): 20 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Trott and K. A. Morano SYM1 Is the Stress-Induced Saccharomyces cerevisiae Ortholog of the Mammalian Kidney Disease Gene Mpv17 and Is Required for Ethanol Metabolism and Tolerance during Heat Shock Eukaryot. Cell, June 1, 2004; 3(3): 620 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Buzello, C. S. Haas, F. Hauptmann, M. L. Gross, J. Faulhaber, S. Schultze-Mosgau, H. Ehmke, E. Ritz, and K. Amann No aggravation of renal injury in apolipoprotein E knockout mice (ApoE-/-) after subtotal nephrectomy Nephrol. Dial. Transplant., March 1, 2004; 19(3): 566 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Sanden, J. E. Wiggins, M. Goyal, L. K. Riggs, and R. C. Wiggins Evaluation of a Thick and Thin Section Method for Estimation of Podocyte Number, Glomerular Volume, and Glomerular Volume Per Podocyte in Rat Kidney with Wilms' Tumor-1 Protein Used as a Podocyte Nuclear Marker J. Am. Soc. Nephrol., October 1, 2003; 14(10): 2484 - 2493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Iida, T. Yasuda, E. Tsubota, H. Takatsuka, M. Masuyama, T. Matsuki, and K. Kishi M-LP, Mpv17-like Protein, Has a Peroxisomal Membrane Targeting Signal Comprising a Transmembrane Domain and a Positively Charged Loop and Up-regulates Expression of the Manganese Superoxide Dismutase Gene J. Biol. Chem., February 14, 2003; 278(8): 6301 - 6306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Pavenstadt, W. Kriz, and M. Kretzler Cell Biology of the Glomerular Podocyte Physiol Rev, January 1, 2003; 83(1): 253 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nosadini and G. Tonolo Cardiovascular and Renal Protection in Type 2 Diabetes Mellitus: The Role of Calcium Channel Blockers J. Am. Soc. Nephrol., November 1, 2002; 13(90003): S216 - 223. [Abstract] [Full Text]
|
|
|
|
|
|
S. Greiber, B. Muller, P. Daemisch, and H. Pavenstadt Reactive Oxygen Species Alter Gene Expression in Podocytes: Induction of Granulocyte Macrophage-Colony-Stimulating Factor J. Am. Soc. Nephrol., January 1, 2002; 13(1): 86 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lavaud, B. Poirier, C. Mandet, M.-F. Belair, T. Irinopoulou, D. Heudes, R. Bazin, J. Bariety, I. Myara, and J. Chevalier Inflammation is probably not a prerequisite for renal interstitial fibrosis in normoglycemic obese rats Am J Physiol Renal Physiol, April 1, 2001; 280(4): F683 - F694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. REGELE, E. FILLIPOVIC, B. LANGER, H. POCZEWKI, I. KRAXBERGER, R. E. BITTNER, and D. KERJASCHKI Glomerular Expression of Dystroglycans Is Reduced in Minimal Change Nephrosis But Not in Focal Segmental Glomerulosclerosis J. Am. Soc. Nephrol., March 1, 2000; 11(3): 403 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. LENZ, S. J. ELLIOT, and W. G. STETLER-STEVENSON Matrix Metalloproteinases in Renal Development and Disease J. Am. Soc. Nephrol., March 1, 2000; 11(3): 574 - 581. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
