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(American Journal of Pathology. 1999;154:1643-1647.)
© 1999 American Society for Investigative Pathology

Short Communication

Activating c-kit Gene Mutations in Human Germ Cell Tumors

Qingsheng Tian*, Henry F. Frierson, Jr.*, Geoffrey W. Krystal{dagger} and Christopher A. Moskaluk*{ddagger}

Departments of Pathology*
and Biochemistry and Molecular Genetics,{ddagger}
University of Virginia Health Sciences Center, Charlottesville, and Department of Medicine,{dagger}
Medical College of Virginia Commonwealth University, McGuire Veterans Affairs Medical Center, Richmond, Virginia

The c-kit gene encodes a tyrosine kinase receptor (KIT) that is required in normal spermatogenesis and is expressed in seminomas and dysgerminomas, a subset of human germ cell tumors (GCTs). To determine whether activating mutations of the c-kit gene occur in GCTs, primary tissue samples of 33 testicular and ovarian tumors were examined for mutations in the juxtamembrane and phosphotransferase domains by polymerase chain reaction amplification and DNA sequencing. A novel missense mutation (D816H) was found in the phosphotransferase domain in tumors of seminoma/dysgerminoma differentiation. The c-kit alleles in nonneoplastic tissues from these patients were wild type, suggesting that the mutant alleles were acquired and selected for during malignant transformation. In cell transfection experiments, the D816H mutant protein was a constitutively activated kinase and was constitutively phosphorylated on tyrosine residues. This is the first description of an activating c-kit mutation in GCTs and is evidence that the KIT signal transduction pathway is important in the pathogenesis of neoplasms with seminoma differentiation.




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