| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
From the Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands
Hodgkin's lymphoma is characterized by the combination of Reed-Sternberg (R-S) cells and a prominent inflammatory cell infiltrate. One of the intriguing questions regarding this disease is what is causing the influx of T lymphocytes into the involved tissues. We applied the serial analysis of gene expression (SAGE) technique on the Hodgkin's lymphoma-derived cell line L428 and on an Epstein-Barr virus (EBV)-transformed lymphoblastoid B-cell line. A frequently expressed tag in L428 corresponded to the T-cell-directed CC chemokine TARC. Reverse transcription polymerase chain reaction analyses demonstrated expression of TARC in nodular sclerosis (NS) and mixed cellularity (MC) classical Hodgkin's lymphomas but not in NLP Hodgkin's lymphoma, anaplastic large-cell lymphomas, and large-B-cell lymphomas with CD30 positivity. Two of five cases of T-cell-rich B-cell lymphoma (TCRBCL) were TARC positive. RNA in situ hybridization (ISH) showed a strong signal for TARC in the cytoplasm of R-S cells, and immunohistochemical staining confirmed the presence of the TARC protein in the R-S cells of NS and MC Hodgkin's lymphomas. The lymphocytic and histiocytic (L&H)-type cells of nodular lymphocyte predominance Hodgkin's lymphoma and the neoplastic cells of non-Hodgkin's lymphomas with the exception of two cases of TCRBCL did not stain for TARC. TARC is known to bind to the CCR4 receptor, which is expressed on activated Th2 lymphocytes. The immunophenotype of lymphocytes surrounding R-S cells is indeed Th2-like, and by RNA ISH these lymphocytes showed a positive signal for the chemokine receptor CCR4. The findings suggest that production of TARC by the R-S cells may explain the characteristic T-cell infiltrate in classical Hodgkin's lymphoma.
This article has been cited by other articles:
 |
|
 |
|
  D. Buglio, G. V. Georgakis, S. Hanabuchi, K. Arima, N. M. Khaskhely, Y.-J. Liu, and A. Younes Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines Blood, August 15, 2008; 112(4): 1424 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ma, L. Visser, H. Roelofsen, M. de Vries, A. Diepstra, G. van Imhoff, T. van der Wal, M. Luinge, G. Alvarez-Llamas, H. Vos, et al. Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes Blood, February 15, 2008; 111(4): 2339 - 2346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Bartlett, A. Younes, M. H. Carabasi, A. Forero, J. D. Rosenblatt, J. P. Leonard, S. H. Bernstein, R. G. Bociek, J. M. Lorenz, B. W. Hart, et al. A phase 1 multidose study of SGN-30 immunotherapy in patients with refractory or recurrent CD30+ hematologic malignancies Blood, February 15, 2008; 111(4): 1848 - 1854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Haas, L. Schopp, B. Storch-Hagenlocher, B. Fritzsching, C. Jacobi, L. Milkova, B. Fritz, A. Schwarz, E. Suri-Payer, M. Hensel, et al. Specific recruitment of regulatory T cells into the CSF in lymphomatous and carcinomatous meningitis Blood, January 15, 2008; 111(2): 761 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Kapatai and P Murray Contribution of the Epstein Barr virus to the molecular pathogenesis of Hodgkin lymphoma J. Clin. Pathol., December 1, 2007; 60(12): 1342 - 1349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Savoldo, C. M. Rooney, A. Di Stasi, H. Abken, A. Hombach, A. E. Foster, L. Zhang, H. E. Heslop, M. K. Brenner, and G. Dotti Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30{zeta} artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease Blood, October 1, 2007; 110(7): 2620 - 2630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Diepstra, G. W. van Imhoff, H. E. Karim-Kos, A. van den Berg, G. J. te Meerman, M. Niens, I. M. Nolte, E. Bastiaannet, M. Schaapveld, E. Vellenga, et al. HLA Class II Expression by Hodgkin Reed-Sternberg Cells Is an Independent Prognostic Factor in Classical Hodgkin's Lymphoma J. Clin. Oncol., July 20, 2007; 25(21): 3101 - 3108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Zangani, M. Froyland, G. Y. Qiu, L. A. Meza-Zepeda, J. L. Kutok, K. M. Thompson, L. A. Munthe, and B. Bogen Lymphomas can develop from B cells chronically helped by idiotype-specific T cells J. Exp. Med., May 14, 2007; 204(5): 1181 - 1191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Biggar, E. S. Jaffe, J. J. Goedert, A. Chaturvedi, R. Pfeiffer, E. A. Engels, and for the HIV/AIDS Cancer Match Study Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS Blood, December 1, 2006; 108(12): 3786 - 3791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Renne, J. I. Martin-Subero, M. Eickernjager, M.-L. Hansmann, R. Kuppers, R. Siebert, and A. Brauninger Aberrant Expression of ID2, a Suppressor of B-Cell-Specific Gene Expression, in Hodgkin's Lymphoma Am. J. Pathol., August 1, 2006; 169(2): 655 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ishida, T. Ishii, A. Inagaki, H. Yano, H. Komatsu, S. Iida, H. Inagaki, and R. Ueda Specific Recruitment of CC Chemokine Receptor 4-Positive Regulatory T Cells in Hodgkin Lymphoma Fosters Immune Privilege Cancer Res., June 1, 2006; 66(11): 5716 - 5722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Cronshaw, A. Kouroumalis, R. Parry, A. Webb, Z. Brown, and S. G. Ward Evidence that phospholipase C-dependent, calcium-independent mechanisms are required for directional migration of T lymphocytes in response to the CCR4 ligands CCL17 and CCL22 J. Leukoc. Biol., June 1, 2006; 79(6): 1369 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kakinuma and S. T. Hwang Chemokines, chemokine receptors, and cancer metastasis J. Leukoc. Biol., April 1, 2006; 79(4): 639 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Weihrauch, O. Manzke, M. Beyer, H. Haverkamp, V. Diehl, H. Bohlen, J. Wolf, and J. L. Schultze Elevated Serum Levels of CC Thymus and Activation-Related Chemokine (TARC) in Primary Hodgkin's Disease: Potential for a Prognostic Factor Cancer Res., July 1, 2005; 65(13): 5516 - 5519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Re, R. K. Thomas, K. Behringer, and V. Diehl From Hodgkin disease to Hodgkin lymphoma: biologic insights and therapeutic potential Blood, June 15, 2005; 105(12): 4553 - 4560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Rust, G Harms, T Blokzijl, M Boot, A Diepstra, J Kluiver, L Visser, S-C Peh, M Lim, W A Kamps, et al. High expression of Mcl-1 in ALK positive and negative anaplastic large cell lymphoma J. Clin. Pathol., May 1, 2005; 58(5): 520 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shimauchi, S. Imai, R. Hino, and Y. Tokura Production of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine by CCR4+ Adult T-Cell Leukemia Cells Clin. Cancer Res., March 15, 2005; 11(6): 2427 - 2435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Poppema Immunobiology and Pathophysiology of Hodgkin Lymphomas Hematology, January 1, 2005; 2005(1): 231 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Bollard, L. Aguilar, K. C. Straathof, B. Gahn, M. H. Huls, A. Rousseau, J. Sixbey, M. V. Gresik, G. Carrum, M. Hudson, et al. Cytotoxic T Lymphocyte Therapy for Epstein-Barr Virus+ Hodgkin's Disease J. Exp. Med., December 20, 2004; 200(12): 1623 - 1633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ishida, S. Iida, Y. Akatsuka, T. Ishii, M. Miyazaki, H. Komatsu, H. Inagaki, N. Okada, T. Fujita, K. Shitara, et al. The CC Chemokine Receptor 4 as a Novel Specific Molecular Target for Immunotherapy in Adult T-Cell Leukemia/Lymphoma Clin. Cancer Res., November 15, 2004; 10(22): 7529 - 7539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Cronshaw, C. Owen, Z. Brown, and S. G. Ward Activation of Phosphoinositide 3-Kinases by the CCR4 Ligand Macrophage-Derived Chemokine Is a Dispensable Signal for T Lymphocyte Chemotaxis J. Immunol., June 15, 2004; 172(12): 7761 - 7770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Crawford, S. X. Yan, S. B. Ortega, R. S. Mehta, R. E. Hewitt, D. A. Price, P. Stastny, D. C. Douek, R. A. Koup, M. K. Racke, et al. High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay Blood, June 1, 2004; 103(11): 4222 - 4231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hanamoto, T. Nakayama, H. Miyazato, S. Takegawa, K. Hieshima, Y. Tatsumi, A. Kanamaru, and O. Yoshie Expression of CCL28 by Reed-Sternberg Cells Defines a Major Subtype of Classical Hodgkin's Disease with Frequent Infiltration of Eosinophils and/or Plasma Cells Am. J. Pathol., March 1, 2004; 164(3): 997 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Poppema Regulatory T cells in Hodgkin lymphoma Blood, March 1, 2004; 103(5): 1565 - 1566. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kato, S. Khan, N. Gonzalez, B. P. O'Neill, K. J. McDonald, B. J. Cooper, N. Z. Angel, and D. N. J. Hart Hodgkin's Lymphoma Cell Lines Express a Fusion Protein Encoded by Intergenically Spliced mRNA for the Multilectin Receptor DEC-205 (CD205) and a Novel C-type Lectin Receptor DCL-1 J. Biol. Chem., September 5, 2003; 278(36): 34035 - 34041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mareel and A. Leroy Clinical, Cellular, and Molecular Aspects of Cancer Invasion Physiol Rev, April 1, 2003; 83(2): 337 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C.M. Straathof, C. M. Bollard, C. M. Rooney, and H. E. Heslop Immunotherapy for Epstein-Barr Virus-Associated Cancers in Children Oncologist, February 1, 2003; 8(1): 83 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Imgrund, R. Rohrbach, M.-O. Oksuz, and W. Grotz Unusual course of nephrotic syndrome associated with atypical pneumonia Nephrol. Dial. Transplant., August 1, 2002; 17(8): 1530 - 1532. [Full Text] [PDF]
|
|
|
|
|
|
A. van den Berg, E. Maggio, R. Rust, K. Kooistra, A. Diepstra, and S. Poppema Clonal relation in a case of CLL, ALCL, and Hodgkin composite lymphoma Blood, July 30, 2002; 100(4): 1425 - 1429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. De Bleecker, B. De Paepe, I. E. Vanwalleghem, and J. M. Schroder Differential expression of chemokines in inflammatory myopathies Neurology, June 25, 2002; 58(12): 1779 - 1785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F. Skinnider and T. W. Mak The role of cytokines in classical Hodgkin lymphoma Blood, May 29, 2002; 99(12): 4283 - 4297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S A Pileri, S Ascani, L Leoncini, E Sabattini, P L Zinzani, P P Piccaluga, A Pileri Jr, M Giunti, B Falini, G B Bolis, et al. Hodgkin's lymphoma: the pathologist's viewpoint J. Clin. Pathol., March 1, 2002; 55(3): 162 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. E. Hopken, H.-D. Foss, D. Meyer, M. Hinz, K. Leder, H. Stein, and M. Lipp Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs Blood, February 15, 2002; 99(4): 1109 - 1116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Aldinucci, D. Poletto, A. Gloghini, P. Nanni, M. Degan, T. Perin, P. Ceolin, F. M. Rossi, V. Gattei, A. Carbone, et al. Expression of Functional Interleukin-3 Receptors on Hodgkin and Reed-Sternberg Cells Am. J. Pathol., February 1, 2002; 160(2): 585 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Oelmann, H. Herbst, M. Zuhlsdorf, O. Albrecht, A. Nolte, C. Schmitmann, O. Manzke, V. Diehl, H. Stein, and W. E. Berdel Tissue inhibitor of metalloproteinases 1 is an autocrine and paracrine survival factor, with additional immune-regulatory functions, expressed by Hodgkin/Reed-Sternberg cells Blood, January 1, 2002; 99(1): 258 - 267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Fiumara, F. Cabanillas, and A. Younes Interleukin-13 levels in serum from patients with Hodgkin disease and healthy volunteers Blood, November 1, 2001; 98(9): 2877 - 2878. [Full Text] [PDF]
|
|
|
|
|
|
A. L. N. Chapman, A. B. Rickinson, W. A. Thomas, R. F. Jarrett, J. Crocker, and S. P. Lee Epstein-Barr Virus-specific Cytotoxic T Lymphocyte Responses in the Blood and Tumor Site of Hodgkin's Disease Patients: Implications for a T-cell-based Therapy Cancer Res., August 1, 2001; 61(16): 6219 - 6226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cecilia Berin, L. Eckmann, D. H. Broide, and M. F. Kagnoff Regulated Production of the T Helper 2-Type T-Cell Chemoattractant TARC by Human Bronchial Epithelial Cells In Vitro and in Human Lung Xenografts Am. J. Respir. Cell Mol. Biol., April 1, 2001; 24(4): 382 - 389. [Abstract] [Full Text]
|
|
|
|
|
|
C. Buri, M. Korner, P. Scharli, D. Cefai, M. Uguccioni, C. Mueller, J. A. Laissue, and L. Mazzucchelli CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease Blood, March 15, 2001; 97(6): 1543 - 1548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kuroda, T. Sugiura, K. Okada, K. Zeki, and U. Yamashita Prostaglandin E2 Up-Regulates Macrophage-Derived Chemokine Production but Suppresses IFN-Inducible Protein-10 Production by APC J. Immunol., February 1, 2001; 166(3): 1650 - 1658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kuppers, A. Brauninger, M. Muschen, V. Distler, M.-L. Hansmann, and K. Rajewsky Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions Blood, February 1, 2001; 97(3): 818 - 821. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F. Skinnider, A. J. Elia, R. D. Gascoyne, L. H. Trumper, F. von Bonin, U. Kapp, B. Patterson, B. E. Snow, and T. W. Mak Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma Blood, January 1, 2001; 97(1): 250 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Chrast, H. S. Scott, M. P. Papasavvas, C. Rossier, E. S. Antonarakis, C. Barras, M. T. Davisson, C. Schmidt, X. Estivill, M. Dierssen, et al. The Mouse Brain Transcriptome by SAGE: Differences in Gene Expression between P30 Brains of the Partial Trisomy 16 Mouse Model of Down Syndrome (Ts65Dn) and Normals Genome Res., December 1, 2000; 10(12): 2006 - 2021. [Abstract] [Full Text]
|
|
|
|
 |
|
 G Niedobitek Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma Mol. Pathol., October 1, 2000; 53(5): 248 - 254. [Abstract] [Full Text]
|
|
|
|
|
|
D. F. Dukers, P. Meij, M. B. H. J. Vervoort, W. Vos, R. J. Scheper, C. J. L. M. Meijer, E. Bloemena, and J. M. Middeldorp Direct Immunosuppressive Effects of EBV-Encoded Latent Membrane Protein 1 J. Immunol., July 15, 2000; 165(2): 663 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Willenbrock, A. Roers, B. Blohbaum, K. Rajewsky, and M.-L. Hansmann CD8+ T Cells in Hodgkin's Disease Tumor Tissue Are a Polyclonal Population with Limited Clonal Expansion but Little Evidence of Selection by Antigen Am. J. Pathol., July 1, 2000; 157(1): 171 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Stine, C. Wood, M. Hill, A. Epp, C. J. Raport, V. L. Schweickart, Y. Endo, T. Sasaki, G. Simmons, C. Boshoff, et al. KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells Blood, February 15, 2000; 95(4): 1151 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Muschen, K. Rajewsky, A. Brauninger, A. S. Baur, J. J. Oudejans, A. Roers, M.-L. Hansmann, and R. Kuppers Rare Occurrence of Classical Hodgkin's Disease as a T Cell Lymphoma J. Exp. Med., January 17, 2000; 191(2): 387 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kuppers, U. Klein, M.-L. Hansmann, and K. Rajewsky Cellular Origin of Human B-Cell Lymphomas N. Engl. J. Med., November 11, 1999; 341(20): 1520 - 1529. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
