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(American Journal of Pathology. 1999;155:85-92.)
© 1999 American Society for Investigative Pathology

Regular Articles

Lipid Deposition in Rat Aortas with Intraluminal Hemispherical Plug Stenosis

A Morphological and Biophysical Study

Thomas Zand*, Allen H. Hoffman{dagger}, Brian J. Savilonis{dagger}, Jean M. Underwood*, John J. Nunnari*, Guido Majno* and Isabelle Joris*

From the Department of Pathology,*
University of Massachusetts Medical School, Worcester, Massachusetts; and the Department of Mechanical Engineering,{dagger}
Worcester Polytechnic Institute, Worcester, Massachusetts

A new method was devised to create a stenosis in the rat abdominal aorta. To restrict blood flow, a hemispherical plug was inserted into the aorta through a renal artery. This type of intrinsic (intraluminal) stenosis minimizes possible intramural effects associated with external compression or ligation which severely deform the arterial wall. In the aorta of hypercholesterolemic rats, lipid deposits were distributed in crescent-shaped patches proximal and distal to the plug, whereas lipid deposition in the opposite aortic wall was inhibited. Based on enlarged physical scale models used to study the flow field, the regions of lipid deposition were found to coincide with regions of low shear stress, stagnation, and recirculation. Shear stress was elevated at the wall opposite the plug. These results show that when confounding mural effects are minimized, lipid deposition is promoted in regions of low shear stress with recirculation and inhibited in regions of elevated shear stress.




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