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Short Communication |
From the Theodor Kocher Institute,*
University of Bern,
Bern, Switzerland; and the Department of Internal Medicine and
Gastroenterology,
University of Bologna,
Bologna, Italy
Chemokines are thought to be important for the recruitment of
granulocytes and mononuclear cells and thus for the maintenance of
inflammation in ulcerative colitis (UC). We have studied the expression
of interferon-
inducible protein-10 (IP-10), interleukin-8
(IL-8), monocyte chemoattractant protein (MCP)-1,
MCP-3, and macrophage inflammatory protein (MIP)-1
in UC
patients and control individuals to assess the role of these chemokines
in disease progression. Colonic biopsies were taken endoscopically from
patients and controls, frozen immediately and subsequently
stained for IP-10, IL-8, MCP-1, MCP-3,
and MIP-1 in serial sections. Cells infiltrating the lamina propria
but not epithelial cells express the analyzed chemokines. They were
differentiated and counted, and chemokine-expressing cells were
quantified by image analysis. The percentage of cells expressing
IP-10, IL-8, MCP-1, and MCP-3 was significantly
enhanced in all UC samples as compared to controls. Expression in the
controls was borderline, except for IP-10. No expression of
MIP-1 was found in controls and UC. IP-10 was also markedly
expressed in the mucosa of control biopsies and therefore could have a
role in activated T lymphocytes' recruitment into the healthy
mucosa.
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