| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
From the Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
To examine if the muscle fibers in patients with inflammatory myopathies have the potential to behave as antigen presenting cells (APCs), we investigated the expression of costimulatory molecules BB-1, B7-1 (CD80), and B7-2 (CD86), and their counterreceptors, CD28 or CTLA-4 (CD152), in the muscle biopsies of patients with polymyositis (PM), PM associated with human immunodeficiency virus infection (HIV-PM), sporadic inclusion body myositis (s-IBM), dermatomyositis (DM), and normal or disease controls. The expression of the B7 family of molecules on the muscle fibers was limited to BB-1. In PM, HIV-PM, and s-IBM, but not the disease controls, the nonnecrotic, MHC-class I-expressing muscle fibers, invaded or not by CD8+ T cells, had prominent membrane expression of BB-1. Several of the BB-1-positive fibers bound strongly in a cell-to-cell contact with their CD28 or CTLA-4 ligands on the autoinvasive CD8+ T cells, as confirmed by confocal microscopy. By reverse transcription-polymerase chain reaction, the expression of CD28 and CTLA-4 was up-regulated in PM, HIV-PM, and s-IBM, but not the controls. Because the BB-1-positive fibers expressed MHC-class I antigen and bound to up-regulated counterreceptors CD28 and CTLA-4 on the autoinvasive CD8+ T cells only in PM, HIV-PM, and s-IBM, the BB-1 molecule in these diseases should have a functional role in antigen presentation and T cell differentiation. These findings complement recent studies and suggest that in PM, HIV-PM, and s-IBM the muscle fibers are not only targets of CD8+ cytotoxic T cells but may also behave as "professional" APC.
This article has been cited by other articles:
 |
|
 |
|
  Y. Katsumata, M. Harigai, T. Sugiura, M. Kawamoto, Y. Kawaguchi, Y. Matsumoto, K. Kohyama, M. Soejima, N. Kamatani, and M. Hara Attenuation of Experimental Autoimmune Myositis by Blocking ICOS-ICOS Ligand Interaction J. Immunol., September 15, 2007; 179(6): 3772 - 3779. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Dimitri, O. Benveniste, O. Dubourg, T. Maisonobe, B. Eymard, Z. Amoura, L. Jean, K. Tiev, J.-C. Piette, D. Klatzmann, et al. Shared blood and muscle CD8+ T-cell expansions in inclusion body myositis Brain, April 1, 2006; 129(4): 986 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Dalakas Inflammatory, immune, and viral aspects of inclusion-body myositis Neurology, January 24, 2006; 66(1_suppl_1): S33 - S38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Fratta, W. K. Engel, J. McFerrin, K. J.A. Davies, S. W. Lin, and V. Askanas Proteasome Inhibition and Aggresome Formation in Sporadic Inclusion-Body Myositis and in Amyloid-{beta} Precursor Protein-Overexpressing Cultured Human Muscle Fibers Am. J. Pathol., August 1, 2005; 167(2): 517 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Nakajima-Takenaka, S. Sakata, S. Kato, Y. Ohga, K.-y. Murata, S. Taniguchi, and M. Takaki Detrimental effects after dobutamine infusion on rat left ventricular function: mechanical work and energetics Exp Physiol, July 1, 2005; 90(4): 635 - 644. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Mason, M. I. Bowmer, C. M. Howley, and M. D. Grant Cross-Reactive Cytotoxic T Lymphocytes against Human Immunodeficiency Virus Type 1 Protease and Gamma Interferon-Inducible Protein 30 J. Virol., May 1, 2005; 79(9): 5529 - 5536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yoshikawa, H. Hagihara, Y. Ohga, C. Nakajima-Takenaka, K.-y. Murata, S. Taniguchi, and M. Takaki Calpain inhibitor-1 protects the rat heart from ischemia-reperfusion injury: analysis by mechanical work and energetics Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1690 - H1698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hagihara, Y. Yoshikawa, Y. Ohga, C. Takenaka, K.-y. Murata, S. Taniguchi, and M. Takaki Na+/Ca2+ exchange inhibition protects the rat heart from ischemia-reperfusion injury by blocking energy-wasting processes Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1699 - H1707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Schmidt, G. Rakocevic, R. Raju, and M. C. Dalakas Upregulated inducible co-stimulator (ICOS) and ICOS-ligand in inclusion body myositis muscle: significance for CD8+ T cell cytotoxicity Brain, May 1, 2004; 127(5): 1182 - 1190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wiendl, M. Mitsdoerffer, D. Schneider, A. Melms, H. Lochmuller, R. Hohlfeld, and M. Weller Muscle fibres and cultured muscle cells express the B7.1/2-related inducible co-stimulatory molecule, ICOSL: implications for the pathogenesis of inflammatory myopathies Brain, May 1, 2003; 126(5): 1026 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wiendl, M. Mitsdoerffer, V. Hofmeister, J. Wischhusen, E. H. Weiss, J. Dichgans, H. Lochmuller, R. Hohlfeld, A. Melms, and M. Weller The non-classical MHC molecule HLA-G protects human muscle cells from immune-mediated lysis: implications for myoblast transplantation and gene therapy Brain, January 1, 2003; 126(1): 176 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M C DALAKAS Progress in inflammatory myopathies: good but not good enough J. Neurol. Neurosurg. Psychiatry, May 1, 2001; 70(5): 569 - 573. [Full Text] [PDF]
|
|
|
|
|
|
M. C. Dalakas, B. Koffman, M. Fujii, S. Spector, K. Sivakumar, and E. Cupler A controlled study of intravenous immunoglobulin combined with prednisone in the treatment of IBM Neurology, February 13, 2001; 56(3): 323 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Amemiya, R. P. Granger, and M. C. Dalakas Clonal restriction of T-cell receptor expression by infiltrating lymphocytes in inclusion body myositis persists over time: Studies in repeated muscle biopsies Brain, October 1, 2000; 123(10): 2030 - 2039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-y. Murata and M. C. Dalakas Expression of the co-stimulatory molecule BB-1, the ligands CTLA-4 and CD28 and their mRNAs in chronic inflammatory demyelinating polyneuropathy Brain, August 1, 2000; 123(8): 1660 - 1666. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
