help button home button Am J Pathol Epitomics, Inc.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hibi, K.
Right arrow Articles by Jen, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hibi, K.
Right arrow Articles by Jen, J.
(American Journal of Pathology. 1999;155:711-715.)
© 1999 American Society for Investigative Pathology

Short Communication

PGP9.5 As a Candidate Tumor Marker for Non-Small-Cell Lung Cancer

Kenji Hibi*, William H. Westra*{dagger}, Michael Borges{ddagger}, Steve Goodman{ddagger}, David Sidransky*{ddagger} and Jin Jen*{ddagger}

From the Department of Otolaryngology–Head and Neck Surgery, Division of Head and Neck Cancer Research,*
and the Departments of Pathology{dagger}
and Oncology,{ddagger}
Johns Hopkins University School of Medicine, Baltimore, Maryland

PGP9.5 is a neurospecific peptide that functions to remove ubiquitin from ubiquitinated proteins and prevents them from targeted degradation by proteasomes. Using the serial analysis of gene expression method (SAGE), we observed that the PGP9.5 transcript was highly expressed in primary lung cancers and lung cancer cell lines but was not detectable in the normal lung. Here we examined the expression of PGP9.5 protein in normal lung epithelium, lung tumor cell lines, and 98 resected primary non-small-cell lung carcinomas (NSCLCs). We found PGP9.5 reactivity in normal lung in a pattern compatible with K-cells of the diffuse neuroendocrine system. However, the PGP9.5 was present in both small-cell lung cancer (SCLC) and NSCLC cell lines (22/24) independent of neuronal differentiation. In primary NSCLCs, 54% (53/98) of the cases had positive PGP9.5 staining, and the expression of protein was strongly associated with pathological stage of the cancer. It was present in 44% (29/66) of stage I NSCLCs and in 75% (24/32) of stage II and IIIA NSCLCs (p = 0.0032). These results suggest that the increased expression of PGP9.5 is specifically associated with lung cancer development and may serve as a potential marker for the detection of lung cancer.




This article has been cited by other articles:


Home page
 INT J SURG PATHOLHome page
A. Mastoraki, E. Ioannidis, A. Apostolaki, E. Patsouris, and K. Aroni
PGP 9.5 and Cyclin D1 Coexpression in Cutaneous Squamous Cell Carcinomas
International Journal of Surgical Pathology, December 1, 2009; 17(6): 413 - 420.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Z. Liu, R. K. Meray, T. N. Grammatopoulos, R. A. Fredenburg, M. R. Cookson, Y. Liu, T. Logan, and P. T. Lansbury Jr.
Membrane-associated farnesylated UCH-L1 promotes {alpha}-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease
PNAS, March 24, 2009; 106(12): 4635 - 4640.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
V. M. Howell, A. Gill, A. Clarkson, A. E. Nelson, R. Dunne, L. W. Delbridge, B. G. Robinson, B. T. Teh, O. Gimm, and D. J. Marsh
Accuracy of Combined Protein Gene Product 9.5 and Parafibromin Markers for Immunohistochemical Diagnosis of Parathyroid Carcinoma
J. Clin. Endocrinol. Metab., February 1, 2009; 94(2): 434 - 441.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
J. Madoz-Gurpide, R. Kuick, H. Wang, D. E. Misek, and S. M. Hanash
Integral Protein Microarrays for the Identification of Lung Cancer Antigens in Sera That Induce a Humoral Immune Response
Mol. Cell. Proteomics, February 1, 2008; 7(2): 268 - 281.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. R. Pereira-Faca, R. Kuick, E. Puravs, Q. Zhang, A. L. Krasnoselsky, D. Phanstiel, J. Qiu, D. E. Misek, R. Hinderer, M. Tammemagi, et al.
Identification of 14-3-3{theta} as an Antigen that Induces a Humoral Response in Lung Cancer
Cancer Res., December 15, 2007; 67(24): 12000 - 12006.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
P. S. Reddy, K. D. Burroughs, L. M. Hales, S. Ganesh, B. H. Jones, N. Idamakanti, C. Hay, S. S. Li, K. L. Skele, A.-J. Vasko, et al.
Seneca Valley Virus, a Systemically Deliverable Oncolytic Picornavirus, and the Treatment of Neuroendocrine Cancers
J Natl Cancer Inst, November 7, 2007; 99(21): 1623 - 1633.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. K. Meray and P. T. Lansbury Jr.
Reversible Monoubiquitination Regulates the Parkinson Disease-associated Ubiquitin Hydrolase UCH-L1
J. Biol. Chem., April 6, 2007; 282(14): 10567 - 10575.
[Abstract] [Full Text] [PDF]

Home page
 Veterinary PathologyHome page
J. A. Ramos-Vara and M. A. Miller
Immunohistochemical Detection of Protein Gene Product 9.5 (PGP 9.5) in Canine Epitheliotropic T-Cell Lymphoma (Mycosis Fungoides)
Veterinary Pathology, January 1, 2007; 44(1): 74 - 79.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. Seliger, A. Fedorushchenko, W. Brenner, A. Ackermann, D. Atkins, S. Hanash, and R. Lichtenfels
Ubiquitin COOH-Terminal Hydrolase 1: A Biomarker of Renal Cell Carcinoma Associated with Enhanced Tumor Cell Proliferation and Migration[?Q1: Running head: UCHL1, a Biomarker of RCC. Short title OK?Q1]
Clin. Cancer Res., January 1, 2007; 13(1): 27 - 37.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. J. Carolan, A. Heguy, B.-G. Harvey, P. L. Leopold, B. Ferris, and R. G. Crystal
Up-regulation of Expression of the Ubiquitin Carboxyl-Terminal Hydrolase L1 Gene in Human Airway Epithelium of Cigarette Smokers.
Cancer Res., November 15, 2006; 66(22): 10729 - 10740.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Tokumaru, K. Yamashita, M. Osada, S. Nomoto, D.-I. Sun, Y. Xiao, M. O. Hoque, W. H. Westra, J. A. Califano, and D. Sidransky
Inverse Correlation between Cyclin A1 Hypermethylation and p53 Mutation in Head and Neck Cancer Identified by Reversal of Epigenetic Silencing
Cancer Res., September 1, 2004; 64(17): 5982 - 5987.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Fukuoka, T. Fujii, J. H. Shih, T. Dracheva, D. Meerzaman, A. Player, K. Hong, S. Settnek, A. Gupta, K. Buetow, et al.
Chromatin Remodeling Factors and BRM/BRG1 Expression as Prognostic Indicators in Non-Small Cell Lung Cancer
Clin. Cancer Res., July 1, 2004; 10(13): 4314 - 4324.
[Abstract] [Full Text] [PDF]

Home page
 Br J OphthalmolHome page
G J Ebenezer and E Daniel
Expression of protein gene product 9.5 in lepromatous eyes showing ciliary body nerve damage and a "dying back" phenomenon in the posterior ciliary nerves
Br J Ophthalmol, February 1, 2004; 88(2): 178 - 181.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Sugita, M. Geraci, B. Gao, R. L. Powell, F. R. Hirsch, G. Johnson, R. Lapadat, E. Gabrielson, R. Bremnes, P. A. Bunn, et al.
Combined Use of Oligonucleotide and Tissue Microarrays Identifies Cancer/Testis Antigens as Biomarkers in Lung Carcinoma
Cancer Res., July 15, 2002; 62(14): 3971 - 3979.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. Chen, T. G. Gharib, C.-C. Huang, D. G. Thomas, K. A. Shedden, J. M. G. Taylor, S. L. R. Kardia, D. E. Misek, T. J. Giordano, M. D. Iannettoni, et al.
Proteomic Analysis of Lung Adenocarcinoma: Identification of a Highly Expressed Set of Proteins in Tumors
Clin. Cancer Res., July 1, 2002; 8(7): 2298 - 2305.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Yamazaki, K. Hibi, T. Takase, E. Tezel, H. Nakayama, Y. Kasai, K. Ito, S. Akiyama, T. Nagasaka, and A. Nakao
PGP9.5 as a Marker for Invasive Colorectal Cancer
Clin. Cancer Res., January 1, 2002; 8(1): 192 - 195.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
H. Sasaki, H. Yukiue, S. Moriyama, Y. Kobayashi, Y. Nakashima, M. Kaji, I. Fukai, M. Kiriyama, Y. Yamakawa, and Y. Fujii
Expression of the Protein Gene Product 9.5, PGP9.5, is Correlated with T-status in Non-small Cell Lung Cancer
Jpn. J. Clin. Oncol., November 1, 2001; 31(11): 532 - 535.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Brichory, D. Beer, F. LeNaour, T. Giordano, and S. Hanash
Proteomics-based Identification of Protein Gene Product 9.5 as a Tumor Antigen That Induces a Humoral Immune Response in Lung Cancer
Cancer Res., November 1, 2001; 61(21): 7908 - 7912.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
K. Polyak and G. J. Riggins
Gene Discovery Using the Serial Analysis of Gene Expression Technique: Implications for Cancer Research
J. Clin. Oncol., June 1, 2001; 19(11): 2948 - 2958.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Tezel, K. Hibi, T. Nagasaka, and A. Nakao
PGP9.5 as a Prognostic Factor in Pancreatic Cancer
Clin. Cancer Res., December 1, 2000; 6(12): 4764 - 4767.
[Abstract] [Full Text]

Home page
 Am. J. Roentgenol.Home page
P. M. Boiselle, A. Ernst, and D. D. Karp
Lung Cancer Detection in the 21st Century: Potential Contributions and Challenges of Emerging Technologies
Am. J. Roentgenol., November 1, 2000; 175(5): 1215 - 1221.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the American Society for Investigative Pathology.