help button home button Am J Pathol ASIP WHAT IS IT?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maniotis, A. J.
Right arrow Articles by Hendrix, M. J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maniotis, A. J.
Right arrow Articles by Hendrix, M. J. C.
(American Journal of Pathology. 1999;155:739-752.)
© 1999 American Society for Investigative Pathology

Regular Articles

Vascular Channel Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry

Andrew J. Maniotis*{dagger}, Robert Folberg{dagger}{ddagger}§, Angela Hess*, Elisabeth A. Seftor*{dagger}, Lynn M.G. Gardner{ddagger}, Jacob Pe'er, Jeffrey M. Trent||, Paul S. Meltzer|| and Mary J. C. Hendrix*{dagger}

From the Departments of Anatomy and Cell Biology,*
University of Iowa Cancer Center,{dagger}
and the Departments of Ophthalmology and Visual Sciences{ddagger}
and Pathology,§
University of Iowa College of Medicine, Iowa City, Iowa; the Department of Ophthalmology,
Hadassah University Hospital, Jerusalem, Israel; and the Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland||

Tissue sections from aggressive human intraocular (uveal) and metastatic cutaneous melanomas generally lack evidence of significant necrosis and contain patterned networks of interconnected loops of extracellular matrix. The matrix that forms these loops or networks may be solid or hollow. Red blood cells have been detected within the hollow channel components of this patterned matrix histologically, and these vascular channel networks have been detected in human tumors angiographically. Endothelial cells were not identified within these matrix-embedded channels by light microscopy, by transmission electron microscopy, or by using an immunohistochemical panel of endothelial cell markers (Factor VIII-related antigen, Ulex, CD31, CD34, and KDR[Flk-1]). Highly invasive primary and metastatic human melanoma cells formed patterned solid and hollow matrix channels (seen in tissue sections of aggressive primary and metastatic human melanomas) in three-dimensional cultures containing Matrigel or dilute Type I collagen, without endothelial cells or fibroblasts. These tumor cell-generated patterned channels conducted dye, highlighting looping patterns visualized angiographically in human tumors. Neither normal melanocytes nor poorly invasive melanoma cells generated these patterned channels in vitro under identical culture conditions, even after the addition of conditioned medium from metastatic pattern-forming melanoma cells, soluble growth factors, or regimes of hypoxia. Highly invasive and metastatic human melanoma cells, but not poorly invasive melanoma cells, contracted and remodeled floating hydrated gels, providing a biomechanical explanation for the generation of microvessels in vitro. cDNA microarray analysis of highly invasive versus poorly invasive melanoma tumor cells confirmed a genetic reversion to a pluripotent embryonic-like genotype in the highly aggressive melanoma cells. These observations strongly suggest that aggressive melanoma cells may generate vascular channels that facilitate tumor perfusion independent of tumor angiogenesis.




This article has been cited by other articles:


Home page
 Stem CellsHome page
Q. Shu, K. K. Wong, J. M. Su, A. M. Adesina, L. T. Yu, Y. T. M. Tsang, B. C. Antalffy, P. Baxter, L. Perlaky, J. Yang, et al.
Direct Orthotopic Transplantation of Fresh Surgical Specimen Preserves CD133+ Tumor Cells in Clinically Relevant Mouse Models of Medulloblastoma and Glioma
Stem Cells, June 1, 2008; 26(6): 1414 - 1424.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
P. R. van Ginkel, S. R. Darjatmoko, D. Sareen, L. Subramanian, S. Bhattacharya, M. J. Lindstrom, D. M. Albert, and A. S. Polans
Resveratrol Inhibits Uveal Melanoma Tumor Growth via Early Mitochondrial Dysfunction
Invest. Ophthalmol. Vis. Sci., April 1, 2008; 49(4): 1299 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Bakalian, J.-C. Marshall, P. Logan, D. Faingold, S. Maloney, S. Di Cesare, C. Martins, B. F. Fernandes, and M. N. Burnier Jr.
Molecular Pathways Mediating Liver Metastasis in Patients with Uveal Melanoma
Clin. Cancer Res., February 15, 2008; 14(4): 951 - 956.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
B. Sun, S. Zhang, D. Zhang, X. Yin, S. Wang, Y. Gu, and Y. Wang
Doxycycline Influences Microcirculation Patterns in B16 Melanoma
Experimental Biology and Medicine, November 1, 2007; 232(10): 1300 - 1307.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. Papadopulos-Eleopulos, B. A. P. Page, D. Causer, V. F. Turner, J. M. Papadimitriou, and A. Maniotis
Cancer and Epigenetic Reversion The Fundamental Role of Redox
Am. J. Pathol., November 1, 2007; 171(5): 1726 - 1727.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
L. W. Horton, Y. Yu, S. Zaja-Milatovic, R. M. Strieter, and A. Richmond
Opposing Roles of Murine Duffy Antigen Receptor for Chemokine and Murine CXC Chemokine Receptor-2 Receptors in Murine Melanoma Tumor Growth
Cancer Res., October 15, 2007; 67(20): 9791 - 9799.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
V. Barak, S. Frenkel, K. Valyi-Nagy, L. Leach, M. A. Apushkin, A. Y. Lin, I. Kalickman, N. A. Baumann, J. Pe'er, A. J. Maniotis, et al.
Using the Direct-Injection Model of Early Uveal Melanoma Hepatic Metastasis to Identify TPS as a Potentially Useful Serum Biomarker
Invest. Ophthalmol. Vis. Sci., October 1, 2007; 48(10): 4399 - 4402.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Z. Zhou, M. F. Bolontrade, K. Reddy, X. Duan, H. Guan, L. Yu, D. J. Hicklin, and E. S. Kleinerman
Suppression of Ewing's Sarcoma Tumor Growth, Tumor Vessel Formation, and Vasculogenesis Following Anti Vascular Endothelial Growth Factor Receptor-2 Therapy
Clin. Cancer Res., August 15, 2007; 13(16): 4867 - 4873.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. Martin and R. Schilder
Novel Approaches in Advancing the Treatment of Epithelial Ovarian Cancer: The Role of Angiogenesis Inhibition
J. Clin. Oncol., July 10, 2007; 25(20): 2894 - 2901.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
R. Folberg, L. Leach, K. Valyi-Nagy, A. Y. Lin, M. A. Apushkin, Z. Ai, V. Barak, D. Majumdar, J. Pe'er, and A. J. Maniotis
Modeling the Behavior of Uveal Melanoma in the Liver
Invest. Ophthalmol. Vis. Sci., July 1, 2007; 48(7): 2967 - 2974.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
T. Meir, M. Zeschnigk, L. Masshofer, J. Pe'er, and I. Chowers
The Spatial Distribution of Monosomy 3 and Network Vasculogenic Mimicry Patterns in Uveal Melanoma
Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 1918 - 1922.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
G. P. Robertson
Mig-7 Linked to Vasculogenic Mimicry
Am. J. Pathol., May 1, 2007; 170(5): 1454 - 1456.
[Full Text] [PDF]

Home page
 JCOHome page
A. Pezzolo, F. Parodi, M. V. Corrias, R. Cinti, C. Gambini, and V. Pistoia
Tumor Origin of Endothelial Cells in Human Neuroblastoma
J. Clin. Oncol., February 1, 2007; 25(4): 376 - 383.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
B. Dome, M. J.C. Hendrix, S. Paku, J. Tovari, and J. Timar
Alternative Vascularization Mechanisms in Cancer: Pathology and Therapeutic Implications
Am. J. Pathol., January 1, 2007; 170(1): 1 - 15.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. Bruno, B. Bussolati, C. Grange, F. Collino, M. E. Graziano, U. Ferrando, and G. Camussi
CD133+ Renal Progenitor Cells Contribute to Tumor Angiogenesis
Am. J. Pathol., December 1, 2006; 169(6): 2223 - 2235.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J Heidemann, D G Binion, W Domschke, and T Kucharzik
Antiangiogenic therapy in human gastrointestinal malignancies.
Gut, October 1, 2006; 55(10): 1497 - 1511.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. Folberg, Z. Arbieva, J. Moses, A. Hayee, T. Sandal, S. Kadkol, A. Y. Lin, K. Valyi-Nagy, S. Setty, L. Leach, et al.
Tumor Cell Plasticity in Uveal Melanoma: Microenvironment Directed Dampening of the Invasive and Metastatic Genotype and Phenotype Accompanies the Generation of Vasculogenic Mimicry Patterns
Am. J. Pathol., October 1, 2006; 169(4): 1376 - 1389.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. D. Onken, J. P. Ehlers, L. A. Worley, J. Makita, Y. Yokota, and J. W. Harbour
Functional Gene Expression Analysis Uncovers Phenotypic Switch in Aggressive Uveal Melanomas.
Cancer Res., May 1, 2006; 66(9): 4602 - 4609.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Tzukerman, T. Rosenberg, I. Reiter, S. Ben-Eliezer, G. Denkberg, R. Coleman, Y. Reiter, and K. Skorecki
The influence of a human embryonic stem cell-derived microenvironment on targeting of human solid tumor xenografts.
Cancer Res., April 1, 2006; 66(7): 3792 - 3801.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. S. Kadkol, A. Y. Lin, V. Barak, I. Kalickman, L. Leach, K. Valyi-Nagy, D. Majumdar, S. Setty, A. J. Maniotis, R. Folberg, et al.
Osteopontin expression and serum levels in metastatic uveal melanoma: a pilot study.
Invest. Ophthalmol. Vis. Sci., March 1, 2006; 47(3): 802 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Girnita, C. All-Ericsson, M. A. Economou, K. Astrom, M. Axelson, S. Seregard, O. Larsson, and L. Girnita
The Insulin-Like Growth Factor-I Receptor Inhibitor Picropodophyllin Causes Tumor Regression and Attenuates Mechanisms Involved in Invasion of Uveal Melanoma Cells
Clin. Cancer Res., February 15, 2006; 12(4): 1383 - 1391.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Nakahara, S. M. Norberg, D. R. Shalinsky, D. D. Hu-Lowe, and D. M. McDonald
Effect of Inhibition of Vascular Endothelial Growth Factor Signaling on Distribution of Extravasated Antibodies in Tumors
Cancer Res., February 1, 2006; 66(3): 1434 - 1445.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
R. D. Braun and A. Abbas
Orthotopic Human Choroidal Melanoma Xenografts in Nude Rats with Aggressive and Nonaggressive PAS Staining Patterns
Invest. Ophthalmol. Vis. Sci., January 1, 2006; 47(1): 7 - 16.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. W.J. van der Schaft, F. Hillen, P. Pauwels, D. A. Kirschmann, K. Castermans, M. G.A. oude Egbrink, M. G.B. Tran, R. Sciot, E. Hauben, P. C.W. Hogendoorn, et al.
Tumor Cell Plasticity in Ewing Sarcoma, an Alternative Circulatory System Stimulated by Hypoxia
Cancer Res., December 15, 2005; 65(24): 11520 - 11528.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. E. Fathers, C. M. Stone, K. Minhas, J. J.A. Marriott, J. D. Greenwood, D. J. Dumont, and B. L. Coomber
Heterogeneity of Tie2 Expression in Tumor Microcirculation: Influence of Cancer Type, Implantation Site, and Response to Therapy
Am. J. Pathol., December 1, 2005; 167(6): 1753 - 1762.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. A. Seftor, K. M. Brown, L. Chin, D. A. Kirschmann, W. W. Wheaton, A. Protopopov, B. Feng, Y. Balagurunathan, J. M. Trent, B. J. Nickoloff, et al.
Epigenetic Transdifferentiation of Normal Melanocytes by a Metastatic Melanoma Microenvironment
Cancer Res., November 15, 2005; 65(22): 10164 - 10169.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
R. Clarijs, M. van Dijk, D. J. Ruiter, and R. M. W. de Waal
Functional and Morphologic Analysis of the Fluid-Conducting Meshwork in Xenografted Cutaneous and Primary Uveal Melanoma
Invest. Ophthalmol. Vis. Sci., September 1, 2005; 46(9): 3013 - 3020.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Larrivee, K. Niessen, I. Pollet, S. Y. Corbel, M. Long, F. M. Rossi, P. L. Olive, and A. Karsan
Minimal Contribution of Marrow-Derived Endothelial Precursors to Tumor Vasculature
J. Immunol., September 1, 2005; 175(5): 2890 - 2899.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
W.-Y. Yue and Z.-P. Chen
Does Vasculogenic Mimicry Exist in Astrocytoma?
J. Histochem. Cytochem., August 1, 2005; 53(8): 997 - 1002.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
I. C. Notting, J. T. Buijs, I. Que, R. E. Mintardjo, G. van der Horst, M. Karperien, G. S. O. A. Missotten, N. E. Schalij-Delfos, J. E. E. Keunen, and G. van der Pluijm
Whole-Body Bioluminescent Imaging of Human Uveal Melanoma in a New Mouse Model of Local Tumor Growth and Metastasis
Invest. Ophthalmol. Vis. Sci., May 1, 2005; 46(5): 1581 - 1587.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
G. S. Stein
Mechanogenomic Control of DNA Exposure and Sequestration
Am. J. Pathol., April 1, 2005; 166(4): 959 - 962.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. J. Maniotis, K. Valyi-Nagy, J. Karavitis, J. Moses, V. Boddipali, Y. Wang, R. Nunez, S. Setty, Z. Arbieva, M. J. Bissell, et al.
Chromatin Organization Measured by AluI Restriction Enzyme Changes with Malignancy and Is Regulated by the Extracellular Matrix and the Cytoskeleton
Am. J. Pathol., April 1, 2005; 166(4): 1187 - 1203.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Salerno, D. Palmieri, A. Bouadis, D. Halverson, and P. S. Steeg
Nm23-H1 Metastasis Suppressor Expression Level Influences the Binding Properties, Stability, and Function of the Kinase Suppressor of Ras1 (KSR1) Erk Scaffold in Breast Carcinoma Cells
Mol. Cell. Biol., February 15, 2005; 25(4): 1379 - 1388.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
D. W. J. van der Schaft, R. E. B. Seftor, E. A. Seftor, A. R. Hess, L. M. Gruman, D. A. Kirschmann, Y. Yokoyama, A. W. Griffioen, and M. J. C. Hendrix
Effects of Angiogenesis Inhibitors on Vascular Network Formation by Human Endothelial and Melanoma Cells
J Natl Cancer Inst, October 6, 2004; 96(19): 1473 - 1477.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C. Lugassy, H. K. Kleinman, J. A. Engbring, D. R. Welch, J. F. Harms, R. Rufner, G. Ghanem, S. R. Patierno, and R. L. Barnhill
Pericyte-Like Location of GFP-Tagged Melanoma Cells: Ex Vivo and In Vivo Studies of Extravascular Migratory Metastasis
Am. J. Pathol., April 1, 2004; 164(4): 1191 - 1198.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
P. Baluk, S. Morikawa, A. Haskell, M. Mancuso, and D. M. McDonald
Abnormalities of Basement Membrane on Blood Vessels and Endothelial Sprouts in Tumors
Am. J. Pathol., November 1, 2003; 163(5): 1801 - 1815.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
W. Ruf, E. A. Seftor, R. J. Petrovan, R. M. Weiss, L. M. Gruman, N. V. Margaryan, R. E. B. Seftor, Y. Miyagi, and M. J. C. Hendrix
Differential Role of Tissue Factor Pathway Inhibitors 1 and 2 in Melanoma Vasculogenic Mimicry
Cancer Res., September 1, 2003; 63(17): 5381 - 5389.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. R. Hess, E. A. Seftor, R. E. B. Seftor, and M. J. C. Hendrix
Phosphoinositide 3-Kinase Regulates Membrane Type 1-Matrix Metalloproteinase (MMP) and MMP-2 Activity during Melanoma Cell Vasculogenic Mimicry
Cancer Res., August 15, 2003; 63(16): 4757 - 4762.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
X. Chen, Z. Ai, M. Rasmussen, P. Bajcsy, L. Auvil, M. Welge, L. Leach, S. Vangveeravong, A. J. Maniotis, and R. Folberg
Three-Dimensional Reconstruction of Extravascular Matrix Patterns and Blood Vessels in Human Uveal Melanoma Tissue: Techniques and Preliminary Findings
Invest. Ophthalmol. Vis. Sci., July 1, 2003; 44(7): 2834 - 2840.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H.-C. Cheng, M. Abdel-Ghany, and B. U. Pauli
A Novel Consensus Motif in Fibronectin Mediates Dipeptidyl Peptidase IV Adhesion and Metastasis
J. Biol. Chem., June 27, 2003; 278(27): 24600 - 24607.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
R.'a T. Al-Jamal, T. Makitie, and T. Kivela
Nucleolar Diameter and Microvascular Factors as Independent Predictors of Mortality from Malignant Melanoma of the Choroid and Ciliary Body
Invest. Ophthalmol. Vis. Sci., June 1, 2003; 44(6): 2381 - 2389.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
D. D. Klisovic, S. E. Katz, D. Effron, M. I. Klisovic, J. Wickham, M. R. Parthun, M. Guimond, and G. Marcucci
Depsipeptide (FR901228) Inhibits Proliferation and Induces Apoptosis in Primary and Metastatic Human Uveal Melanoma Cell Lines
Invest. Ophthalmol. Vis. Sci., June 1, 2003; 44(6): 2390 - 2398.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
S. Garattini
New approaches to cancer therapy
Ann. Onc., June 1, 2003; 14(6): 813 - 816.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
S. M. Rybak, E. Sanovich, M. G. Hollingshead, S. D. Borgel, D. L. Newton, G. Melillo, D. Kong, G. Kaur, and E. A. Sausville
"Vasocrine" Formation of Tumor Cell-lined Vascular Spaces: Implications for Rational Design of Antiangiogenic Therapies
Cancer Res., June 1, 2003; 63(11): 2812 - 2819.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. F. C. M. Smetsers, E. M. A. van de Westerlo, G. B. ten Dam, R. Clarijs, E. M. M. Versteeg, W. L. van Geloof, J. H. Veerkamp, G. N. P. van Muijen, and T. H. van Kuppevelt
Localization and Characterization of Melanoma-associated Glycosaminoglycans: Differential Expression of Chondroitin and Heparan Sulfate Epitopes in Melanoma
Cancer Res., June 1, 2003; 63(11): 2965 - 2970.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
R. Clarijs, L. Schalkwijk, D. J. Ruiter, and R. M. W. de Waal
EMAP-II Expression Is Associated with Macrophage Accumulation in Primary Uveal Melanoma
Invest. Ophthalmol. Vis. Sci., May 1, 2003; 44(5): 1801 - 1806.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. Mareel and A. Leroy
Clinical, Cellular, and Molecular Aspects of Cancer Invasion
Physiol Rev, April 1, 2003; 83(2): 337 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. Walker-Daniels, A. R. Hess, M. J.C. Hendrix, and M. S. Kinch
Differential Regulation of EphA2 in Normal and Malignant Cells
Am. J. Pathol., April 1, 2003; 162(4): 1037 - 1042.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. Righi, S. Deaglio, C. Pecchioni, A. Gregorini, A. L. Horenstein, G. Bussolati, A. Sapino, and F. Malavasi
Role of CD31/Platelet Endothelial Cell Adhesion Molecule-1 Expression in in Vitro and in Vivo Growth and Differentiation of Human Breast Cancer Cells
Am. J. Pathol., April 1, 2003; 162(4): 1163 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
T. M. Walker, P. R. van Ginkel, R. L. Gee, H. Ahmadi, L. Subramanian, B. R. Ksander, L. F. Meisner, D. M. Albert, and A. S. Polans
Expression of Angiogenic Factors Cyr61 and Tissue Factor in Uveal Melanoma
Arch Ophthalmol, December 1, 2002; 120(12): 1719 - 1725.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
Y.-J. Lee, N. Nagai, C.-H. Siar, K. Nakano, H. Nagatsuka, H. Tsujigiwa, C.-H. Roan, and M. Gunduz
Angioarchitecture of Primary Oral Malignant Melanomas
J. Histochem. Cytochem., November 1, 2002; 50(11): 1555 - 1562.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Tei, N. Kawakami-Kimura, O. Taguchi, K. Kumamoto, S. Higashiyama, N. Taniguchi, K.'i. Toda, R. Kawata, Y. Hisa, and R. Kannagi
Roles of Cell Adhesion Molecules in Tumor Angiogenesis Induced by Cotransplantation of Cancer and Endothelial Cells to Nude Rats
Cancer Res., November 1, 2002; 62(21): 6289 - 6296.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Herlyn, M. Padarathsingh, L. Chin, M. Hendrix, D. Becker, M. Nelson, Y. DeClerck, J. McCarthy, and S. Mohla
New Approaches to the Biology of Melanoma: A Workshop of the National Institutes of Health Pathology B Study Section
Am. J. Pathol., November 1, 2002; 161(5): 1949 - 1957.
[Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
R. E. B. Seftor, E. A. Seftor, D. A. Kirschmann, and M. J. C. Hendrix
Targeting the Tumor Microenvironment with Chemically Modified Tetracyclines: Inhibition of Laminin 5 {gamma}2 Chain Promigratory Fragments and Vasculogenic Mimicry
Mol. Cancer Ther., November 1, 2002; 1(13): 1173 - 1179.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Liu, H. Huang, F. Donate, C. Dickinson, R. Santucci, A. El-Sheikh, R. Vessella, and T. S. Edgington
Prostate-specific Membrane Antigen Directed Selective Thrombotic Infarction of Tumors
Cancer Res., October 1, 2002; 62(19): 5470 - 5475.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. Favier, P.-F. Plouin, P. Corvol, and J.-M. Gasc
Angiogenesis and Vascular Architecture in Pheochromocytomas : Distinctive Traits in Malignant Tumors
Am. J. Pathol., October 1, 2002; 161(4): 1235 - 1246.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
F. A. Scappaticci
Mechanisms and Future Directions for Angiogenesis-Based Cancer Therapies
J. Clin. Oncol., September 15, 2002; 20(18): 3906 - 3927.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
R. D. Braun, A. Abbas, S. O. Bukhari, and W. Wilson III
Hemodynamic Parameters in Blood Vessels in Choroidal Melanoma Xenografts and Rat Choroid
Invest. Ophthalmol. Vis. Sci., September 1, 2002; 43(9): 3045 - 3052.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W. C. Zamboni, A. C. Gervais, M. J. Egorin, J. H. M. Schellens, D. R. Hamburger, B. J. Delauter, A. Grim, E. G. Zuhowski, E. Joseph, D. Pluim, et al.
Inter- and Intratumoral Disposition of Platinum in Solid Tumors after Administration of Cisplatin
Clin. Cancer Res., September 1, 2002; 8(9): 2992 - 2999.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Jessani, Y. Liu, M. Humphrey, and B. F. Cravatt
Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness
PNAS, August 6, 2002; 99(16): 10335 - 10340.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
X. Chen, A. J. Maniotis, D. Majumdar, J. Pe'er, and R. Folberg
Uveal Melanoma Cell Staining for CD34 and Assessment of Tumor Vascularity
Invest. Ophthalmol. Vis. Sci., August 1, 2002; 43(8): 2533 - 2539.
[Abstract]