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(American Journal of Pathology. 1999;155:1027-1032.)
© 1999 American Society for Investigative Pathology

Short Communication

Expression of Bcl-2 and Amplification of c-myc Are Frequent in Basaloid Squamous Cell Carcinomas of the Esophagus

Mario Sarbia*, Christina Loberg*, Marietta Wolter{ddagger}, Jawed Arjumand*, Hansjörg Heep{dagger}, Guido Reifenberger{ddagger} and Helmut E. Gabbert*

From the Institutes of Pathology*
and Surgery,{dagger}
University of Düsseldorf, Düsseldorf; and the Institute of Neuropathology,{ddagger}
University of Bonn, Bonn, Germany

Basaloid squamous cell carcinoma (BSCC) of the esophagus is a rare, poorly differentiated variant of typical esophageal squamous cell carcinoma (SCC) characterized by high proliferative activity and frequent spontaneous apoptoses. In the present study, we investigated the expression of the apoptosis-suppressing protein Bcl-2 in 23 BSCC of the esophagus and 23 stage-matched typical esophageal SCC by means of immunohistochemistry. In addition, amplification of the apoptosis- and proliferation-inducing gene c-myc was determined by means of differential polymerase chain reaction. Bcl-2 expression was found significantly more often in BSCC than in SCC (86.9% vs. 17.4%, P < 0.0001). Amplification of c-myc was nearly twice as common in BSCC as in SCC (47.8% vs. 26.1%, not significant). Bcl-2 protein expression together with c-myc amplification was detected in 43.5% of the BSCC but in none of the typical SCC (P < 0.0001). Taken together, our findings indicate that the molecular pathogenesis of esophageal BSCC differs from that of typical SCC and frequently involves coactivation of c-myc and Bcl-2.




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