| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Short Communication |
From the Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky
Hepatic ischemia/reperfusion injury is initiated by the activation
of Kupffer cells and their subsequent release of proinflammatory
mediators, including tumor necrosis factor-
(TNF). These
mediators stimulate a cascade of events including up-regulation of CXC
chemokines and vascular endothelial adhesion molecules, leading
to hepatic neutrophil recruitment and tissue injury. Interleukin-13
(IL-13) is a cytokine that has been shown to suppress macrophage
production of proinflammatory mediators. The objective of the current
study was to determine whether IL-13 could regulate the liver
inflammatory injury induced by ischemia and reperfusion. C57BL/6 mice
underwent 90 minutes of partial hepatic ischemia followed by
reperfusion with or without intravenous administration of recombinant
murine IL-13. Hepatic ischemia/reperfusion increased expression of
TNF and macrophage inflammatory protein-2 (MIP-2), leading
to hepatic neutrophil recruitment, hepatocellular
injury, and liver edema. Administration of IL-13 reduced the
production of TNF and MIP-2 mRNA and protein. IL-13 suppressed liver
neutrophil recruitment by up to 72% and hepatocellular injury and
liver edema were each reduced by >60%. Administration of IL-13 had no
effect on liver NF
B activation, but greatly increased the
activation of STAT6. The data suggest that the hepatoprotective effects
of IL-13 may be a result of STAT6 activation.
This article has been cited by other articles:
 |
|
 |
|
  T. Weimbs Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1 Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1423 - F1432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Jaruga, F. Hong, R. Sun, S. Radaeva, and B. Gao Crucial Role of IL-4/STAT6 in T Cell-Mediated Hepatitis: Up-Regulating Eotaxins and IL-5 and Recruiting Leukocytes J. Immunol., September 15, 2003; 171(6): 3233 - 3244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yokota, M. Burne-Taney, L. Racusen, and H. Rabb Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury Am J Physiol Renal Physiol, August 1, 2003; 285(2): F319 - F325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Jaeschke Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning Am J Physiol Gastrointest Liver Physiol, January 1, 2003; 284(1): G15 - G26. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kato, H. Yoshidome, M. J. Edwards, and A. B. Lentsch Regulation of Liver Inflammatory Injury by Signal Transducer and Activator of Transcription-6 Am. J. Pathol., July 1, 2000; 157(1): 297 - 302. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
