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(American Journal of Pathology. 1999;155:1253-1260.)
© 1999 American Society for Investigative Pathology

Regular Articles

Immunohistochemical Evidence of Loss of PTEN Expression in Primary Ductal Adenocarcinomas of the Breast

Aurel Perren*{dagger}{ddagger}, Liang-Ping Weng*, Alexander H. Boag§, Ulricke Ziebold||, Kosha Thakore*{dagger}, Patricia L. M. Dahia*{dagger}, Paul Komminoth{ddagger}, Jacqueline A. Lees||, Lois M. Mulligan§¶, George L. Mutter** and Charis Eng*{dagger}{dagger}

From the Clinical Cancer Genetics and Human Cancer Genetics Programs,*
Ohio State University Comprehensive Cancer Center, Columbus, Ohio; the Dana-Farber Cancer Institute and Harvard Medical School,{dagger}
Boston, Massachusetts; the Department of Pathology,{ddagger}
University of Zürich, Zürich, Switzerland; the Departments of Pathology§
and Paediatrics,
Queen's University, Kingston, Ontario, Canada; the Department of Biology,||
Cancer Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts; the Department of Pathology,**
Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and the CRC Human Cancer Genetics Research Group,{dagger}{dagger}
University of Cambridge, Cambridge, United Kingdom

Germline mutations in PTEN, encoding a dual-specificity phosphatase on 10q23.3, cause Cowden syndrome (CS), which is characterized by a high risk of breast and thyroid cancers. Loss of heterozygosity of 10q22–24 markers and somatic PTEN mutations have been found to a greater or lesser extent in a variety of sporadic component and noncomponent cancers of CS. Among several series of sporadic breast carcinomas, the frequency of loss of flanking markers around PTEN is approximately 30 to 40%, and the somatic intragenic PTEN mutation frequency is <5%. In this study, we analyzed PTEN expression in 33 sporadic primary breast carcinoma samples using immunohistochemistry and correlated this to structural studies at the molecular level. Normal mammary tissue had a distinctive pattern of expression: myoepithelial cells uniformly showed strong PTEN expression. The PTEN protein level in mammary epithelial cells was variable. Ductal hyperplasia with and without atypia exhibited higher PTEN protein levels than normal mammary epithelial cells. Among the 33 carcinoma samples, 5 (15%) were immunohistochemically PTEN-negative; 6 (18%) had reduced staining, and the rest were PTEN-positive. In the PTEN-positive tumors as well as in normal epithelium, the protein was localized in the cytoplasm and in the nucleus (or nuclear membrane). Among the immunostain negative group, all had hemizygous PTEN deletion but no structural alteration of the remaining allele. Thus, in these cases, an epigenetic phenomenon such as hypermethylation, -ecreased protein synthesis or increased protein degradation may be involved. In the cases with reduced staining, 5 of 6 had hemizygous PTEN deletion and 1 did not have any structural abnormality. Finally, clinicopathological features were analyzed against PTEN protein expression. Three of the 5 PTEN immunostain-negative carcinomas were also both estrogen and progesterone receptor-negative, whereas only 5 of 22 of the PTEN-positive group were double receptor-negative. The significance of this last observation requires further study.




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Home page
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Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland
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Hum. Mol. Genet., July 15, 2002; 11(15): 1687 - 1696.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Diagnosis of premalignant endometrial disease
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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Inner ear localization of mRNA and protein products of COCH, mutated in the sensorineural deafness and vestibular disorder, DFNA9
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Home page
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Home page
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Home page
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PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
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Loss of Heterozygosity on 10q23.3 and Mutation of the Tumor Suppressor Gene PTEN in Benign Endometrial Cyst of the Ovary: Possible Sequence Progression from Benign Endometrial Cyst to Endometrioid Carcinoma and Clear Cell Carcinoma of the Ovary
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Home page
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Home page
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[Abstract] [Full Text]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
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J. Clin. Endocrinol. Metab., June 1, 2000; 85(6): 2334 - 2338.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
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Am. J. Pathol., May 1, 2000; 156(5): 1693 - 1700.
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Home page
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Home page
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